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DOI: 10.1055/a-1535-2981
Disseminated cerebral fusariosis in a liver-transplant patient: A case report and review of the literature
Diffuse zerebrale Fusariose in einer lebertransplantierten Patientin Ein Fallbericht und Überblick über die Literatur
Abstract
Fusarium spp. can cause invasive infection with fatal outcomes in immunocompromised patients. Therefore, invasive fusariosis is rare after solid organ transplantation. For this reason, experience and management are limited to single published case reports.
We report a 65-year-old female patient with disseminated brain abscesses caused by Fusarium after liver transplantation (LT). The patient underwent LT for secondary sclerosing cholangitis after acute respiratory distress syndrome (ARDS). After a complicated course with aneurysm and thrombosis of the hepatic artery, re-transplantation was performed after one month. Due to inadequate awakening response, cerebral imaging was performed, which showed multiple abscesses. The patient died shortly thereafter, and an autopsy showed fusariosis.
Zusammenfassung
Fusarium spp. führen bei immungeschwächten Patienten zu einer invasiven Infektion mit meist tödlichem Ausgang. Eine invasive Fusariose wird nach der Transplantation solider Organe jedoch seltener berichtet. Aus diesem Grund ist die Erfahrung und das Management dieses Infektes auf einzelne Fallberichte beschränkt.
Wir berichten von einer 65-jährige Patientin, die nach einer Lebertransplantation (LT) disseminierte Hirnabszesse verursacht durch Fusarien entwickelte. Die Patientin unterzog sich einer LT aufgrund einer sekundär sklerosierender Cholangitis nach akutem Lungenversagen (ARDS). Nach einem komplizierten Verlauf mit Aneurysma und Thrombose der Leberarterie erfolgte nach einem Monat eine Re-Transplantation. Aufgrund der unzureichenden Aufwachreaktion wurde eine zerebrale Bildgebung durchgeführt, die multiple Abszesse zeigte. Die Patientin verstarb kurz darauf, in der Autopsie wurden Fusarien nachgewiesen.
Publication History
Received: 10 June 2021
Accepted: 21 June 2021
Article published online:
15 November 2021
© 2021. Thieme. All rights reserved.
Georg Thieme Verlag KG
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