To the memory of our colleagues Rocío Patiño, Barbarín Arreguín and Gaudencio Anastacio.
Abstract
α,β-Unsaturated δ-lactones are structural motifs found in diverse pharmacologically
active natural products. In fact, the unsaturated lactone is often responsible for
the biological activity. Herein, we report a new approach for the syntheses of (R)-argentilactone and (R)-goniothalamin based on a photoredox intermolecular iodolactonization mediated by
a photoredox process. This new approach, already employed in our research group, stands
as a new methodology to achieve several natural products containing α,β-unsaturated
δ-lactones.
Key words
free-radical lactonization - photoredox catalysis - argentilactone - goniothalamin
- unsaturated lactones
