Fasten und Langlebigkeit

Zusammenfassung

Epidemiologische Studien, unter anderem aus Japan, legen nahe, dass eine Kalorienrestriktion nicht nur im Tierversuch, sondern auch bei Menschen lebensverlängernd wirkt. Unter den zahlreichen Fastenvarianten sind diejenigen mit längerfristigem Fasten am besten geeignet, den Körper in einen Ketosezustand mit hauptsächlicher Fettsäureverbrennung zu bringen. Aktuelle Forschungsansätze drehen sich um die medikamentöse Induktion eines fastenähnlichen Zustands und damit die Aktivierung von Sirtuinen als effektive „Anti-Aging-Enzyme“.

Publication History

Article published online:
07 December 2021

• Literatur

• 1 Cornaro L. Discourses on the sober life (Discorsi della vita sobria), being the personal narrative of Luigi Cornaro. Kessinger Publishing, LLC; 2012
• 2 Mccay CM, Sperling G, Barnes LL. Growth ageing, chronic diseases, and life span in rats. Arch Biochem 1943; 2: 469-479
• 3 Fontana L, Partridge L, Longo VD. Extending healthy life span—from yeast to humans. Science 2010; 328: 321-326
• 4 Colman RJ, Anderson RM, Johnson SC. et al. Calorie restriction delays disease onset and mortality in rhesus monkeys. Science 2009; 325: 201-204
• 5 Willcox BJ, Willcox DC. Caloric restriction, caloric restriction mimetics, and healthy aging in Okinawa: controversies and clinical implications. Curr Opin Clin Nutr Metab Care 2014; 17: 51-58
• 6 Howitz KT, Bitterman KJ, Cohen HY. et al. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 2003; 425: 191-196
• 7 Haigis MC, Guarente LP. Mammalian sirtuins – emerging roles in physiology, aging, and calorie restriction. Genes Dev 2006; 20: 2913-2921
• 8 Klionsky DJ. Autophagy: from phenomenology to molecular understanding in less than a decade. Nat Rev Mol Cell Biol 2007; 8: 931-937
• 9 Martins I, Galluzzi L, Kroemer G. Hormesis, cell death and aging. Aging (Albany NY) 2011; 3: 821-828
• 10 Patterson RE, Laughlin GA, Sears DD. et al. Intermittent fasting and human metabolic health. J Acad Nutr Diet 2015; 115: 1203-1212
• 11 Bjedov I, Partridge L. A longer and healthier life with TOR down-regulation: genetics and drugs. Biochem Soc Trans 2011; 39: 460-465
• 12 Howitz KT, Bitterman KJ, Cohen HY. et al. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 2003; 425: 191-196
• 13 Baur JA, Sinclair DA. Therapeutic potential of resveratrol: the in vivo evidence. Nat Rev Drug Discov 2006; 5: 493-506
• 14 Rahnasto-Rilla M, Tyni J, Huovinen M. et al. Natural polyphenols as Sirtuin 6 modeulators. Scientific Reports 2018; 8: 4163
• 15 Morselli E, Mariño G, Bennetzen MV. et al. Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome. J Cell Biol 2011; 192: 615-629
• 16 De Risi M, Torromino G, Tufano M. et al. Mechanisms by which autophagy regulates memory capacity in ageing. Aging Cell 2020; 19: e13189
• 17 Martin-Montalvo A, Mercken EM, Mitchell SJ. et al. Metformin improves healthspan and lifespan in mice. Nat Commun 2013; 4: 2192
• 18 Anisimov VN, Berstein LM, Popovich IG. et al. If started early in life, metformin treatment increases life span and postpones tumors in female SHR mice. Aging (Albany NY) 2011; 3: 148-157
• 19 Vladimir N, Anisimov VN, Zabezhinski MA, Popovich IG. et al. Rapamycin extends maximal lifespan in cancer-prone mice; Am. J Pathol 2010; 176: 2092-2097