Zeitschrift für Orthomolekulare Medizin 2021; 19(04): 17-23
DOI: 10.1055/a-1698-1495
Wissen

Kann Vitamin C zu Beginn einer akuten Infektion vor schweren Verläufen und post-viraler Fatigue schützen?

Claudia Vollbracht

Zusammenfassung

Ein Defizit an Vitamin C kann das Infektionsrisiko erhöhen. Begleitend bei einem grippalen Infekt eingesetzt, kann Vitamin C die Symptome bei ausreichend hoher Dosierung signifikant abmildern. Auch bei SARS-CoV-2-Infektionen zeigen Studien, dass supportives Vitamin C positive Wirkungen hat. Hochdosiertes intravenöses Vitamin C kann zudem Fatigue, kognitive Störungen und Schmerzen bei Erkrankungen, die mit oxidativem Stress einhergehen, reduzieren. Dass diese Effekte auch bei der Behandlung von Long-COVID-Betroffenen erzielt werden könnten, scheint plausibel.



Publication History

Article published online:
15 December 2021

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  • Literatur

  • 1 Mousavi S, Bereswill S, Heimesaat MM. Immunomodulatory and Antimicrobial Effects of Vitamin C. Eur J Microbiol Immunol (Bp) 2019; 9: 73-79 DOI: 10.1556/1886.2019.00016.
  • 2 Carr AC, Maggini S. Vitamin C and Immune Function. Nutrients 2017; 9; DOI: 10.3390/nu9111211
  • 3 Teafatiller T, Agrawal S, De Robles G, Rahmatpanah F, Subramanian VS, Agrawal A. Vitamin C Enhances Antiviral Functions of Lung Epithelial Cells. Biomolecules 2021; 11; DOI: 10.3390/biom11081148
  • 4 Calder PCCAC, Gombart AF, Eggersdorfer M. Optimal Nutritional Status for a Well-Functioning Immune System is an Important Factor to Protect Against Viral Infections. Preprints 2020
  • 5 Gröber U. Corona, Influenza & Co. Checkliste zum Spitzen-Gespräch http://www.vitaminspur.de/pdf/1.Groe_Spitzen-Gespraech_Corona_2020.pdf
  • 6 Hemila H. Vitamin C and Infections. Nutrients 2017; 9; DOI:10.3390/nu9040339
  • 7 Hemila H, Chalker E. Vitamin C for preventing and treating the common cold. Cochrane Database Syst Rev 2013; DOI: 10.1002/14651858.CD000980.pub4
  • 8 Institute of Medicine (US) Panel on Dietary Antioxidants and Related Compounds. Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, and Carotenoids. Washington (DC) 2000; Vol. National Academies Press (US)
  • 9 Hemila H, Louhiala P. Vitamin C for preventing and treating pneumonia. Cochrane Database Syst Rev 2013; DOI: 10.1002/14651858.CD005532.pub3
  • 10 Carr AC, Rosengrave PC, Bayer S, Chambers S, Mehrtens J, Shaw GM. Hypovitaminosis C and vitamin C deficiency in critically ill patients despite recommended enteral and parenteral intakes. Crit Care 2017; 21: 300 DOI: 10.1186/s13054-017-1891-y.
  • 11 Ran L, Zhao W, Wang H, Zhao Y, Bu H. Vitamin C as a Supplementary Therapy in Relieving Symptoms of the Common Cold: A Meta-Analysis of 10 Randomized Controlled Trials. Biomed Res Int 2020; 2020: 8573742 DOI: 10.1155/2020/8573742.
  • 12 Behera P, Patro BK, Singh AK, Chandanshive PD, SR R, Pradhan SK, Pentapati SSK, Batmanabane G, Mohapatra PR, Padhy BM. et al Role of ivermectin in the prevention of SARS-CoV-2 infection among healthcare workers in India: A matched case-control study. PLoS One 2021; 16: e0247163 DOI: 10.1371/journal.pone.0247163.
  • 13 Kumari P, Dembra S, Dembra P, Bhawna F, Gul A, Ali B, Sohail H, Kumar B, Memon MK, Rizwan A. The Role of Vitamin C as Adjuvant Therapy in COVID-19. Cureus 2020; 12: e11779 DOI: 10.7759/cureus.11779.
  • 14 Zhao B, Liu M, Liu P, Peng Y, Huang J, Li M, Wang Y, Xu L, Sun S, Qi X. et al High Dose Intravenous Vitamin C for Preventing The Disease Aggravation of Moderate COVID-19 Pneumonia. A Retrospective Propensity Matched Before-After Study. Front Pharmacol 2021; 12: 638556 DOI: 10.3389/fphar.2021.638556.
  • 15 Zhang J, Rao X, Li Y, Zhu Y, Liu F, Guo G, Luo G, Meng Z, De Backer D, Xiang H. et al Pilot trial of high-dose vitamin C in critically ill COVID-19 patients. Ann Intensive Care 2021; 11: 5 DOI: 10.1186/s13613-020-00792-3.
  • 16 Gao D, Xu M, Wang G, Lv J, Ma X, Guo Y, Zhang D, Yang H, Jiang W, Deng F. et al. The efficiency and safety of high-dose vitamin C in patients with COVID-19: a retrospective cohort study. Aging (Albany NY) 2021; 13; DOI: 10.18632/aging.202557
  • 17 Zheng S, Chen Q, Jiang H, Guo C, Luo J, Li S, Wang H, Li H, Zheng X, Weng Z. No significant benefit of moderate-dose vitamin C on severe COVID-19 cases. Open Med (Wars) 2021; 16: 1403-1414 DOI: 10.1515/med-2021-0361.
  • 18 Li M, Ching TH, Hipple C, Lopez R, Sahibzada A, Rahman H. Use of Intravenous Vitamin C in Critically Ill Patients With COVID-19 Infection. J Pharm Pract 2021; DOI: 10.1177/08971900211015052
  • 19 Schonrich G, Raftery MJ, Samstag Y. Devilishly radical NETwork in COVID-19: Oxidative stress, neutrophil extracellular traps (NETs), and T cell suppression. Adv Biol Regul 2020; 77: 100741 DOI: 10.1016/j.jbior.2020.100741.
  • 20 Kory P, Meduri GU, Iglesias J, Varon J, Marik PE. Clinical and Scientific Rationale for the "MATH+" Hospital Treatment Protocol for COVID-19. J Intensive Care Med 2021; 36: 135-156 DOI: 10.1177/0885066620973585.
  • 21 Arvinte C, Singh M, Marik PE. Serum Levels of Vitamin C and Vitamin D in a Cohort of Critically Ill COVID-19 Patients of a North American Community Hospital Intensive Care Unit in May 2020: A Pilot Study. Med Drug Discov 2020; 8: 100064 DOI: 10.1016/j.medidd.2020.100064.
  • 22 Pincemail J, Cavalier E, Charlier C, Cheramy-Bien JP, Brevers E, Courtois A, Fadeur M, Meziane S, Goff CL, Misset B. et al. Oxidative Stress Status in COVID-19 Patients Hospitalized in Intensive Care Unit for Severe Pneumonia. A Pilot Study. Antioxidants (Basel) 2021; 10; DOI:10.3390/antiox10020257
  • 23 Lopez-Leon S, Wegman-Ostrosky T, Perelman C, Sepulveda R, Rebolledo P, Cuapio A, Villapol S. More Than 50 Long-Term Effects of COVID-19: A Systematic Review and Meta-Analysis. Res Sq 2021; 10.21203/rs.3.rs-266574/v1; DOI:10.21203/rs.3.rs-266574/v1
  • 24 Augustin M, Schommers P, Stecher M, Dewald F, Gieselmann L, Gruell H, Horn C, Vanshylla K, Cristanziano VD, Osebold L. et al Post-COVID syndrome in non-hospitalised patients with COVID-19: a longitudinal prospective cohort study. Lancet Reg Health Eur 2021; 6: 100122 DOI: 10.1016/j.lanepe.2021.100122.
  • 25 Cohen S. Psychosocial Vulnerabilities to Upper Respiratory Infectious Illness: Implications for Susceptibility to Coronavirus Disease 2019 (COVID-19). Perspect Psychol Sci 2021; 16: 161-174 DOI: 10.1177/1745691620942516.
  • 26 Bleijenberg GvdM JWM. Chapter 442: Chronic Fatigue Syndrome. In: Harrison's Principles of Internal Medicine, 20e. McGraw-Hill Education: USA; 2018
  • 27 Sykes DL, Holdsworth L, Jawad N, Gunasekera P, Morice AH, Crooks MG. Post-COVID-19 Symptom Burden: What is Long-COVID and How Should We Manage It?. Lung 2021; 199: 113-119 DOI: 10.1007/s00408-021-00423-z.
  • 28 Lee JS, Kim HG, Lee DS, Son CG. Oxidative Stress is a Convincing Contributor to Idiopathic Chronic Fatigue. Sci Rep 2018; 8: 12890 DOI: 10.1038/s41598-018-31270-3.
  • 29 Kim TD, Lee S, Yoon S. Inflammation in Post-Traumatic Stress Disorder (PTSD): A Review of Potential Correlates of PTSD with a Neurological Perspective. Antioxidants (Basel) 2020; 9; DOI:10.3390/antiox9020107
  • 30 Moritz B, Schmitz AE, Rodrigues ALS, Dafre AL, Cunha MP. The role of vitamin C in stress-related disorders. J Nutr Biochem 2020; 85: 108459 DOI: 10.1016/j.jnutbio.2020.108459.
  • 31 Alzoubi KH, Shatnawi AF, Al-Qudah MA, Alfaqih MA. Vitamin C attenuates memory loss induced by post-traumatic stress like behavior in a rat model. Behav Brain Res 2020; 379: 112350 DOI: 10.1016/j.bbr.2019.112350.
  • 32 Boldrini M, Canoll PD, Klein RS. How COVID-19 Affects the Brain. JAMA Psychiatry 2021; 10.1001/jamapsychiatry.2021.0500; DOI:10.1001/jamapsychiatry.2021.0500
  • 33 Dotan A, Muller S, Kanduc D, David P, Halpert G, Shoenfeld Y. The SARS-CoV-2 as an instrumental trigger of autoimmunity. Autoimmun Rev 2021; 20: 102792 DOI: 10.1016/j.autrev.2021.102792.
  • 34 Tung ML, Tan B, Cherian R, Chandra B. Anti-phospholipid syndrome and COVID-19 thrombosis: connecting the dots. Rheumatol Adv Pract 2021; 5: rkaa081 DOI: 10.1093/rap/rkaa081.
  • 35 Vollbracht C, Kraft K. Feasibility of Vitamin C in the Treatment of Post Viral Fatigue with Focus on Long COVID, Based on a Systematic Review of IV Vitamin C on Fatigue. Nutrients 2021; 13; DOI:10.3390/nu13041154
  • 36 Holford PCAC, Zawari M, Vizcaychipi MP. Vitamin C Intervention for Critical COVID-19: A Pragmatic Review of the Current Level of Evidence. Life 2021; 11: 1166 DOI: 10.3390/life11111166.
  • 37 JamaliMoghadamSiahkali S, Zarezade B, Koolaji S, SeyedAlinaghi S, Zendehdel A, Tabarestani M, Sekhavati Moghadam E, Abbasian L, Dehghan Manshadi SA, Salehi M. et al Safety and effectiveness of high-dose vitamin C in patients with COVID-19: a randomized open-label clinical trial. Eur J Med Res 2021; 26: 20 DOI: 10.1186/s40001-021-00490-1.
  • 38 Tehrani S, Yadegarynia D, Abrishami A, Moradi H, Gharaei B, Rauofi M, Maghsoudi Nejad F, Sali S, Khabiri N, Abolghasemi S. An investigation into the Effects of Intravenous Vitamin C on Pulmonary CT Findings and Clinical Outcomes of Patients with COVID 19 Pneumonia A Randomized Clinical Trial. Urol J 2021; 10.22037/uj.v18i.6863, 6863; DOI:10.22037/uj.v18i.6863
  • 39 Suna K, Melahat US, Murat Y, Figen OE, Ayperi O. Effect of high-dose intravenous vitamin C on prognosis in patients with SARS-CoV-2 pneumonia. Med Clin (Barc) 2021; 10.1016/j.medcli.2021.04.010; DOI:10.1016/j.medcli.2021.04.010
  • 40 Xia G, Fan D, He Y, Zhu Y, Zheng Q. High-dose intravenous vitamin C attenuates hyperinflammation in severe coronavirus disease 2019. Nutrition 2021; 91–92: 111405 DOI: 10.1016/j.nut.2021.111405.
  • 41 Xia G, Qin B, Ma C, Zhu Y, Zheng Q. High-dose vitamin C ameliorates cardiac injury in COVID-19 pandemic: a retrospective cohort study. Aging (Albany NY) 2021; 13: 20906-20914 DOI: 10.18632/aging.203503.