Physiological Functions of FBW7 in Metabolism

Jianmei Zhang; De-huan Kong; Xiaocheng Huang; Rongbo Yu; Yachao Yang

doi:10.1055/a-1816-8903

Hormone and Metabolic Research, Inhaltsverzeichnis

Horm Metab Res 2022; 54(05): 280-287
DOI: 10.1055/a-1816-8903

Review

Physiological Functions of FBW7 in Metabolism

Jianmei Zhang

¹Department of Endocrinology and Metabolism, Weihai Municipal Hospital Affiliated to Shandong University, Weihai, China

²Department of Geriatrics, Weihai Municipal Hospital Affiliated to Shandong University, Weihai, China

,

De-huan Kong

³Department of Endocrinology, Taian City Central Hospital, Taian, China

,

Xiaocheng Huang

⁴Department of Health examination, Weihai Municipal Hospital affiliated to Shandong University, Weihai, China

,

Rongbo Yu

⁵Department of Geriatrics, Weihai Municipal Hospital Affiliated to Shandong University, Shangdong, China

,

Yachao Yang

⁶Department of Endocrinology and Metabolism, Weihai Municipal Hospital Affiliated to Shandong University, Weihai, China

› Institutsangaben

Abstract

FBW7 is the recognition subunit of the SCF (Skp1-Cullin1-F-box proteins) E3 ubiquitin ligase complex, and it determines the specificity of the SCF substrate. SCFFBW7 is a recognized tumor suppressor because of its ability to degrade many proto-oncogenic substrates. Recent studies have shown that FBW7 plays a key role in metabolism by targeting the degradation of critical regulators involved in cellular metabolism in a ubiquitin-dependent manner. Here, we review recent studies, which highlight the important role of FBW7 in metabolism.

Keywords

FBW7 - glucose metabolism - metabolic syndrome - lipid metabolism - obesity

Volltext

Referenzen

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