Advanced Glycation End Products, Bone Health, and Diabetes
                    Mellitus

Jingjing Jiang; Changyu Zhao; Tingting Han; Hongyan Shan; Guiyou Cui; Songnan Li; Zhongwen Xie; Jun Wang

doi:10.1055/a-1861-2388

Experimental and Clinical Endocrinology & Diabetes, Table of Contents

Exp Clin Endocrinol Diabetes 2022; 130(10): 671-677
DOI: 10.1055/a-1861-2388

Review

Advanced Glycation End Products, Bone Health, and Diabetes Mellitus

Authors

Jingjing Jiang

¹School of Tourism and Cuisine, Yangzhou University, 196 Huayang West Road, Yangzhou, 225127, Jiangsu, P. R. China
Changyu Zhao

¹School of Tourism and Cuisine, Yangzhou University, 196 Huayang West Road, Yangzhou, 225127, Jiangsu, P. R. China
Tingting Han

²State Key Laboratory of Tea Plant Biology and Utilization, Anhui Agricultural University, 130 Changjiang West Road, Hefei, 230036, Anhui, P. R. China
Hongyan Shan

¹School of Tourism and Cuisine, Yangzhou University, 196 Huayang West Road, Yangzhou, 225127, Jiangsu, P. R. China
Guiyou Cui

¹School of Tourism and Cuisine, Yangzhou University, 196 Huayang West Road, Yangzhou, 225127, Jiangsu, P. R. China
Songnan Li

³Joint International Research Laboratory of Agriculture and Agri-Product Safety, the Ministry of Education of China, Institutes of Agricultural Science and Technology Development, Yangzhou University, 48 Wenhui East Road, Yangzhou, 225009, Jiangsu, P. R. China
Zhongwen Xie

²State Key Laboratory of Tea Plant Biology and Utilization, Anhui Agricultural University, 130 Changjiang West Road, Hefei, 230036, Anhui, P. R. China
Jun Wang

¹School of Tourism and Cuisine, Yangzhou University, 196 Huayang West Road, Yangzhou, 225127, Jiangsu, P. R. China

²State Key Laboratory of Tea Plant Biology and Utilization, Anhui Agricultural University, 130 Changjiang West Road, Hefei, 230036, Anhui, P. R. China

Abstract

Advanced glycation end products (AGEs), the compounds resulting from the non-enzymatic glycosylation between reducing sugars and proteins, are derived from food or produced de novo. Over time, more and more endogenous and exogenous AGEs accumulate in various organs such as the liver, kidneys, muscle, and bone, threatening human health. Among these organs, bone is most widely reported. AGEs accumulating in bone reduce bone strength by participating in bone structure formation and breaking bone homeostasis by binding their receptors to alter the proliferation, differentiation, and apoptosis of cells involved in bone remodeling. In this review, we summarize the research about the effects of AGEs on bone health and highlight their associations with bone health in diabetes patients to provide some clues toward the discovery of new treatment and prevention strategies for bone-related diseases caused by AGEs.

Key words

Advanced glycation end products - Bone remodeling - Bone fragility - Diabetes

Full Text

References

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