Diversitätsfaktoren in der Gastroenterologie

Diversitätsfaktoren werden zunehmend als wichtige Einflussgröße für Pathogenese, klinische Manifestation und Therapie von Erkrankungen der Gastroenterologie und Hepatologie erkannt und sollten bei Diagnostik- und Therapieentscheidungen berücksichtigt werden. Am Beispiel chronisch-entzündlicher Darmerkrankungen wird in dieser Übersicht diskutiert, wie Diversitätsfaktoren, z.B. biologisches Geschlecht oder ethnische Herkunft, den Krankheitsverlauf beeinflussen. Diversitätsfaktoren stellen im klinischen Alltag wichtige Bausteine auf dem Weg zu einer personalisierten Medizin dar.

Abstract

Factors related to patient diversity may play a major role in the pathogenesis and clinical manifestation of intestinal and liver diseases and should be considered during diagnostic workup and therapeutic decisions. Here we discuss how diversity factors such as gender, ethnicity, age and socioeconomic parameters may affect the manifestation and disease course of inflammatory bowel diseases (IBD, i.e. Crohn’s disease and ulcerative colitis). Consideration of such factors may help to pave the path towards personalized medicine approaches in clinical practice.

Schlüsselwörter

Alter - Morbus Crohn - Colitis ulcerosa - Infektrisiko - personalisierte Medizin

Keywords

age - Crohn’s disease - ulcerative colitis - risk factors for infection - personalized medicine

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