Abstract
We aimed to compare the definitions of National Institute of Child Health and
Human Development (NICHD) for bronchopulmonary dysplasia (BPD) for determining
the incidences, and predicting late death and respiratory outcome. This
retrospective cohort study included infants born at<32 weeks’
gestation who survived up to 36 weeks’ postmenstrual age (PMA). Infants
were classified as having BPD or no BPD per thedefinitions of NICHD 2001 and
2018. The incidences of BPD were 49 and 32% according to the 2001 and
2018 NICHD definitions. Gestational age, birth weight and intubation after birth
were associated with BPD by both definitions. The NICHD 2018 definition
displayed similar sensitivity (100%) and negative predictive value
(100%), and higher specificity (70 vs. 52%) for predicting death
after 36 weeks’ PMA; a higher specificity (72 vs. 53%),
comparable negative predictive value (77 vs.76%), but lower sensitivity
for predicting adverse respiratory outcome within 12 months corrected age
compared with the NICHD 2001 definition. The NICHD 2018 definition is as
powerful as the 2001 definition for predicting late death and seems to be a
better indicator for long-term respiratory outcome. The use of supplemental
oxygen or oxygen plus respiratory support should be considered while predicting
both late death and long-term respiratory outcome.
Key words
bronchopulmonary dysplasia - preterm - death - respiratory outcome - definition
