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Semin Liver Dis 2022; 42(04): 489-500
DOI: 10.1055/a-1954-4136
Review Article

Novel Biomarkers of AKI in Cirrhosis

Adrià Juanola   *
1   Liver Unit, Hospital Clínic de Barcelona, University of Barcelona, Barcelona, Catalonia, Spain
2   Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Catalonia, Spain
3   Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEReHD), Barcelona, Catalonia, Spain
,
Ann T. Ma   *
2   Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Catalonia, Spain
3   Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEReHD), Barcelona, Catalonia, Spain
,
Elisa Pose   #
1   Liver Unit, Hospital Clínic de Barcelona, University of Barcelona, Barcelona, Catalonia, Spain
2   Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Catalonia, Spain
3   Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEReHD), Barcelona, Catalonia, Spain
,
Pere Ginès   #
1   Liver Unit, Hospital Clínic de Barcelona, University of Barcelona, Barcelona, Catalonia, Spain
2   Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Catalonia, Spain
3   Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEReHD), Barcelona, Catalonia, Spain
4   Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Catalonia, Spain
› Author Affiliations Funding This work has been supported by funding from EU H2020 Research and Innovation programme, no. 731875 (LIVERHOPE). Part of the work has been funded by the Instituto de Salud Carlos III FIS (Fondo de Investigaciones Sanitarias) PI20/00579 and PI18/00727. A.J., A.T.M., E.P., and P.G. have been funded by a grant from AGAUR 2017SGR-01281.
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Abstract

Acute kidney injury (AKI) is a frequent complication in patients with cirrhosis that is associated with poor outcomes and decreased survival. The definition of AKI in cirrhosis is currently based on changes of serum creatinine levels with respect to baseline values. Differential diagnosis of the causes of AKI is of major relevance, considering that some causes of AKI, such as hepatorenal syndrome, have specific treatment options and different prognosis. Prediction of kidney function recovery and patients' survival is also crucial in this patient population to guide clinical decisions. AKI biomarkers in cirrhosis have emerged as a promising tool for differential diagnosis and prognosis in this situation. There are consistent data showing that some urine biomarkers, particularly neutrophil gelatinase-associated lipocalin, may be useful in daily clinical practice for the differential diagnosis of the cause of AKI in cirrhosis. AKI biomarkers may constitute a useful tool for use in differential diagnosis, prognosis of renal function, and survival in patients with cirrhosis. This review focuses on the current state of knowledge and future perspective of novel biomarkers of AKI in cirrhosis.

Keywords

AKI - cirrhosis - HRS - biomarkers - novel - NGAL - IL-18 - cystatin C - KIM-1

* Shared first co-authorship.


# Shared senior authorship.




Publication History

Accepted Manuscript online:
03 October 2022

Article published online:
03 November 2022

© 2022. Thieme. All rights reserved.

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