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Senologie - Zeitschrift für Mammadiagnostik und -therapie 2023; 20(04): 320-329
DOI: 10.1055/a-2183-3490
Übersicht

Update Mammakarzinom 2023 Teil 2 – Brustkrebs in fortgeschrittenen Krankheitsstadien

Update Breast Cancer 2023 Part 2 – Advanced-Stage Breast Cancer
Michael P. Lux
1   Klinik für Gynäkologie und Geburtshilfe, Frauenklinik St. Louise, Paderborn, St. Josefs-Krankenhaus, Salzkotten, St. Vincenz Krankenhaus GmbH, Paderborn, Germany
,
Andreas D. Hartkopf
2   Department of Gynecology and Obstetrics, Ulm University Hospital, Ulm, Germany
,
Tanja N. Fehm
3   Department of Gynecology and Obstetrics, University Hospital Düsseldorf, Düsseldorf, Germany
,
Manfred Welslau
4   Onkologie Aschaffenburg, Aschaffenburg, Germany
,
Volkmar Müller
5   Department of Gynecology, Hamburg-Eppendorf University Medical Center, Hamburg, Germany
,
Florian Schütz
6   Gynäkologie und Geburtshilfe, Diakonissen-Stiftungs-Krankenhaus Speyer, Speyer, Germany
,
Peter A. Fasching
7   Erlangen University Hospital, Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany
,
Wolfgang Janni
2   Department of Gynecology and Obstetrics, Ulm University Hospital, Ulm, Germany
,
Isabell Witzel
8   Klinik für Gynäkologie, Universitätsspital Zürich, Zürich, Switzerland
,
Christoph Thomssen
9   Department of Gynaecology, Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany
,
Milena Beierlein
7   Erlangen University Hospital, Department of Gynecology and Obstetrics, Comprehensive Cancer Center Erlangen-EMN, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany
,
Erik Belleville
10   ClinSol GmbH & Co KG, Würzburg, Germany
,
Michael Untch
11   Clinic for Gynecology and Obstetrics, Breast Cancer Center, Gynecologic Oncology Center, Helios Klinikum Berlin Buch, Berlin, Germany
,
Marc Thill
12   Department of Gynecology and Gynecological Oncology, Agaplesion Markus Krankenhaus, Frankfurt am Main, Germany
,
Hans Tesch
13   Oncology Practice at Bethanien Hospital, Frankfurt am Main, Germany
,
Nina Ditsch
14   Department of Gynecology and Obstetrics, University Hospital Augsburg, Augsburg, Germany
,
Bahriye Aktas
15   Department of Gynecology, University of Leipzig Medical Center, Leipzig, Germany
,
Maggie Banys-Paluchowski
16   Department of Gynecology and Obstetrics, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany
,
Cornelia Kolberg-Liedtke
17   Department of Gynecology and Obstetrics, University Hospital Essen, Essen, Germany
,
Achim Wöckel
18   Department of Gynecology and Obstetrics, University Hospital Würzburg, Würzburg, Germany
,
Hans-Christian Kolberg
19   Department of Gynecology and Obstetrics, Marienhospital Bottrop, Bottrop, Germany
,
Nadia Harbeck
20   Breast Center, Department of Gynecology and Obstetrics and CCC Munich LMU, LMU University Hospital, München, Germany
,
Rupert Bartsch
21   Department of Medicine I, Division of Oncology, Medical University of Vienna, Vienna, Austria
,
Andreas Schneeweiss
22   National Center for Tumor Diseases, University Hospital and German Cancer Research Center, Heidelberg, Germany
,
Johannes Ettl
23   Klinik für Frauenheilkunde und Gynäkologie, Klinikum Kempten, Klinikverbund Allgäu, Kempten, Germany
,
Rachel Würstlein
20   Breast Center, Department of Gynecology and Obstetrics and CCC Munich LMU, LMU University Hospital, München, Germany
,
David Krug
24   Klinik für Strahlentherapie, Universitätsklinkum Schleswig-Holstein, Campus Kiel, Kiel, Germany
,
Florin-Andrei Taran
25   Department of Gynecology and Obstetrics, University Hospital Freiburg, Freiburg, Germany
,
Diana Lüftner
26   Medical University of Brandenburg Theodor-Fontane, Immanuel Hospital Märkische Schweiz, Buckow, Germany
,
Elmar Stickeler
27   Department of Obstetrics and Gynecology, Center for Integrated Oncology (CIO Aachen, Bonn, Cologne, Düsseldorf), University Hospital of RWTH Aachen, Aachen, Germany
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Zusammenfassung

Eine Reihe von neuen Therapien hat in den letzten Jahren die Fortschritte in der Behandlung von Patientinnen mit fortgeschrittenem Mammakarzinom bestimmt. Diese Substanzen sind hauptsächlich die CDK4/6-Inhibitoren und weitere Substanzen, welche die endokrine Resistenz überwinden können, die oralen selektiven Östrogenrezeptor-Degradierer, die Antikörper-Medikament Konjugate (ADCs) und die PARP-Inhibitoren. In dieser Übersichtsarbeit werden die neuesten Studienergebnisse zusammengefasst und bewertet, die in den letzten Monaten veröffentlicht worden sind. Dies beinhaltet die Gesamtüberlebensdaten der Destiny-Breast03-Studie, die erste Analyse der CAPItello-291-Studie, den Vergleich einer CDK4/6-Inhibitor-Therapie mit Chemotherapie in der ersten Therapielinie (RIGHT Choice-Studie), die erste Analyse der Destiny-Breast02-Studie im Therapie-Setting nach T-DM1-Therapie und die erste Analyse der Serena-2-Studie.

Die meisten dieser Studien haben das Potenzial, die Therapielandschaft für Patientinnen mit fortgeschrittenem Mammakarzinom deutlich zu verändern, und zeigen, dass die Entwicklung neuer Therapien mit einer nach wie vor hohen Geschwindigkeit immer neue Ergebnisse produziert.

Abstract

In recent years, a number of new therapies have led to advances in the treatment of patients with advanced breast carcinoma. These substances are mainly CDK4/6 inhibitors and other substances that can overcome endocrine resistance, oral selective estrogen receptor degraders, antibody drug conjugates (ADCs), and PARP inhibitors. This review summarizes and evaluates the latest study results that have been published in recent months. This includes the overall survival data of the Destiny-Breast03 study, the first analysis of the CAPItello-291 study, the comparison of CDK4/6 inhibitor treatment with chemotherapy in the first line of therapy (RIGHT Choice study), the first analysis of the Destiny-Breast02 study in the treatment setting after T-DM1 treatment, and the first analysis of the Serena-2 study.

Most of these studies have the potential to significantly change the therapeutic landscape for patients with advanced breast carcinoma and show that the continued rapid development of new therapies is always producing new results.

Schlüsselwörter

Brustkrebs - metastatisch - endokrine Therapie - Antikörper-Medikament-Konjugat - Chemotherapie

Key words

breast cancer - metastatic - endocrine therapy - antibody drug conjugate - chemotherapy


Publication History

Received: 13 April 2023

Accepted: 14 April 2023

Article published online:
08 December 2023

© 2023. This article was originally published by Thieme as Michael P. Lux et al. Update Breast Cancer 2023 Part 2 – Advanced-Stage Breast Cancer. Geburtsh Frauenheilk 2023; 83: 664–673 as an open access article under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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