Braunes Gold – Kottransplantation als Therapieoption beim Hund

Die Kottransplantation stellt bei gastrointestinalen Erkrankungen eine vielversprechende Therapieoption dar. In diesem Artikel finden Sie eine Übersicht über mögliche Einsatzgebiete, Benefits, Risiken und Selektion der Spender sowie eine praktische Anleitung zur Herstellung und Durchführung einer Kottransplantation beim Hund.

Publication History

Article published online:
23 February 2024

• Literatur

• 1 Zhang F, Cui B, Xingxiang H. et al. Microbiota transplantation: concept, methodology and strategy for its modernization. Protein Cell 2018; 9: 462-473
• 2 Chaitman J, Gaschen F. Fecal Microbiota Transplantation in Dogs. Vet Clin North Am Small Anim Pract 2021; 51: 219-233
• 3 Ziese AL, Suchodolski J. Impact of Changes in Gastrointestinal Microbiota in Canine and Feline Digestive Diseases. Vet Clin North Am Small Pract 2021; 51: 155-169
• 4 Tuniyazi M, Hu X, Fu Y. et al. Canine Fecal Microbiota Transplantation: Current Application and Possible Mechanisms. Vet Sci 2022; 9: 396
• 5 Manchester AC, Webb CB, Blake AB. et al. Long-term impact of tylosin on fecal micobiota an fecal bile acides of healthy dogs. J Vet Intern Med 2019; 33: 2605-2617
• 6 Ott SJ, Wätzig GH, Rehman A. et al. Efficacy of Sterile Fecal Filtrate Transfer for Treating Patients With Clostridium difficile Infection. Gastroenterology 2017; 152: 799-811
• 7 Li K, Yang J, Zhou X. et al. The Mechanism of Important Components in Canine Fecal Microbiota Transplantation. Vet Sci 2022; 9: 695
• 8 Goloshchapov O, Olekhnovich EI, Sidorenko SV. et al. Long-term impact of fecal transplantation in healthy volunteers. BMC Microbiol 2019; 19: 312
• 9 Grellet A, Heilmann RM, Polack B. et al. Influence of Breed Size, Age, Fecal Quality, and Enteropathogen Shedding on Fecal Calprotectin and Immunoglobulin a Concentrations in Puppies During the Weaning Period. J Vet Intern Med 2016; 30: 1056-1064
• 10 Rapoport EA, Baig M, Puli SR. Adverse events in fecal microbiota transplantation: a systematic review and meta-analysis. Ann Gastroenterol 2022; 35: 150-163
• 11 Li K, Zhou X, Zhong Z. et al. Indications for canine fecal microbiota transplantation. Thai J Vet Med 2022; 52: 13-21
• 12 Chaitman J, Ziese AL, Pilla R. et al. Fecal Microbial and Metabolic Profiles in Dogs With Acute Diarrhea Receiving Either Fecal Microbiota Transplantation or Oral Metronidazole. Front Vet Sci 2020; 16: 192
• 13 Nixon SL, Rose L, Muller AT. Efficacy of an orally administered anti-diarrheal probiotic paste (Pro-Kolin Advanced) in dogs with acute diarrhea: A randomized, placebo-controlled, double-blinded clinical study. J Vet Intern Med 2019; 33: 1286-1294
• 14 Gal A, Barko PC, Biggs PJ. et al. One dogʼs waste is another dogʼs wealth: A pilot study of fecal microbiota transplantation in dogs with acute hemorrhagic diarrhea syndrome. Plos One 2021; 16: e0250344
• 15 Unterer S, Busch K. Acute Hemorrhagic Diarrhea Syndrome in Dogs. Vet Clin North Am Small Anim Pract 2021; 51: 79-92
• 16 Pereira GQ, Gomes LA, Santos IS. et al. Fecal microbiota transplantation in puppies with canine parvovirus infection. J Vet Intern Med 2018; 32: 707-711
• 17 Jergens AE, Heilmann RM. Canine chronic enteropathy-Current state-of-the-art and emerging concepts. Front Vet Sci 2022; 9: 923013
• 18 Bottero E, Benvenuti E, Ruggiero P. Faecal microbiota transplantation in 16 dogs with idiopathic inflammatory bowel disease. Veterinaria 2017; 31: 1-12
• 19 Niina A, Kibe R, Suzuki R. et al. Improvement in Clinical Symptoms and Fecal Microbiome After Fecal Microbiota Transplantation in a Dog with Inflammatory Bowel Disease. Vet Med (Auckl) 2019; 10: 197-201
• 20 Chaitman J, Jergens AE, Gaschen F. et al. Commentary on key aspects of fecal microbiota transplantation in small animal practice. Vet Med (Auckl) 2016; 7: 71-74
• 21 AlShawaqfeh MK, Wajid B, Minamoto Y. et al. A dysbiosis index to assess microbial changes in fecal samples of dogs with chronic inflammatory enteropathy. FEMS Microbiol Ecol 2017; 93: 11
• 22 Cammarota G, Ianiro G, Tilg H. et al. European consensus conference on faecal microbiota transplantation in clinical practice. Gut 2017; 66: 569-580