Giardien – ein Blick über den Tellerrand

Der vorliegende Artikel bietet detaillierte Einblicke in die aktuelle Forschung zu Giardien beim Hund. Er beleuchtet die Zusammenhänge zwischen Giardieninfektionen, Antiparasitika und dem Mikrobiom. Ernährungsbedingte Einflussfaktoren und therapeutische Strategien werden erörtert. Die Therapie soll die Auswirkungen des Giardienbefalls minimieren und die Darmgesundheit unterstützen.

• Literatur

• 1 Bouzid M, Halai K, Jeffreys D. et al. The prevalence of Giardia infection in dogs and cats, a systematic review and meta-analysis of prevalence studies from stool samples. Veterinary Parasitology 2015; 207: 181-202
• 2 Sommer MF, Rupp P, Pietsch M. et al. Giardia in a selected population of dogs and cats in Germany – diagnostics, coinfections and assemblages. Veterinary Parasitology 2018; 249: 49-56
• 3 Murnik L-C, Daugschies A, Delling C. Gastrointestinal parasites in young dogs and risk factors associated with infection. Parasitol Res 2023; 122: 585-596
• 4 Barutzki D, Schaper R. Results of Parasitological Examinations of Faecal Samples from Cats and Dogs in Germany between 2003 and 2010. Parasitol Res 2011; 109: 45-60
• 5 Kanski S, Weber K, Busch K. Ein Update zur felinen und caninen Giardiose. Tierarztl Prax Ausg K Kleintiere Heimtiere 2023; 51: 411-421
• 6 Ciuca L, Pepe P, Bosco A. et al. Effectiveness of Fenbendazole and Metronidazole Against Giardia Infection in Dogs Monitored for 50-Days in Home-Conditions. Front Vet Sci 2021; 8: 626424
• 7 Peruzzo A, Vascellari M, Massaro A. et al. Giardia duodenalis Colonization Slightly Affects Gut Microbiota and Hematological Parameters in Clinically Healthy Dogs. Animals 2023; 13: 958
• 8 Tysnes KR, Skancke E, Robertson LJ. Subclinical Giardia in dogs: a veterinary conundrum relevant to human infection. Trends in Parasitology 2014; 30: 520-527
• 9 Cotton JA, Beatty JK, Buret AG. Host parasite interactions and pathophysiology in Giardia infections. International Journal for Parasitology 2011; 41: 925-933
• 10 Buret AG, Mitchell K, Muench DG. et al. Giardia lamblia disrupts tight junctional ZO-1 and increases permeability in non-transformed human small intestinal epithelial monolayers: effects of epidermal growth factor. Parasitology 2002; 125: 11-19
• 11 Niewiem M, Grzybowska-Chlebowczyk U. Intestinal Barrier Permeability in Allergic Diseases. Nutrients 2022; 14: 1893
• 12 Liu Z, Li N, Neu J. Tight junctions, leaky intestines, and pediatric diseases. Acta Paediatrica 2005; 94: 386-393
• 13 Wensaas KA, Hanevik K, Hausken T. et al. Postinfectious and sporadic functional gastrointestinal disorders have different prevalences and rates of overlap: results from a controlled cohort study 3 years after acute giardiasis. Neurogastroenterology Motil 2016; 28: 1561-1569
• 14 Fekete E, Allain T, Siddiq A. et al. Giardia spp. and the Gut Microbiota: Dangerous Liaisons. Front Microbiol 2021; 11: 618106
• 15 Chaitman J, Ziese A-L, Pilla R. et al. Fecal Microbial and Metabolic Profiles in Dogs With Acute Diarrhea Receiving Either Fecal Microbiota Transplantation or Oral Metronidazole. Front Vet Sci 2020; 7: 192
• 16 Volkmann M, Steiner JM, Fosgate GT. et al. Chronic Diarrhea in Dogs – Retrospective Study in 136 Cases. Veterinary Internal Medicne 2017; 31: 1043-1055
• 17 Pilla R, Gaschen FP, Barr JW. et al. Effects of metronidazole on the fecal microbiome and metabolome in healthy dogs. Veterinary Internal Medicne 2020; 34: 1853-1866
• 18 Rudinsky AJ, Parker VJ, Winston J. et al. Randomized controlled trial demonstrates nutritional management is superior to metronidazole for treatment of acute colitis in dogs. javma 2022; 260: S23-S32
• 19 Lee NN, Bidot WA, Ericsson AC. et al. Effects of Giardia lamblia Colonization and Fenbendazole Treatment on Canine Fecal Microbiota. j am assoc lab anim sci 2020;
• 20 Fujishiro MA, Lidbury JA, Pilla R. et al. Evaluation of the effects of anthelmintic administration on the fecal microbiome of healthy dogs with and without subclinical Giardia spp. and Cryptosporidium canis infections. PLoS ONE 2020; 15: e0228145
• 21 Lappin MR, Zug A, Hovenga C. et al. Efficacy of feeding a diet containing a high concentration of mixed fiber sources for management of acute large bowel diarrhea in dogs in shelters. Veterinary Internal Medicne 2022; 36: 488-492
• 22 Allain T, Fekete E, Sosnowski O. et al. High-fat diet increases the severity of Giardia infection in association with low-grade inflammation and gut microbiota dysbiosis. Sci Rep 2021; 11: 18842
• 23 Leitch GJ, Udezulu IA, He Q. et al. Effects of Protein Malnutrition on Experimental Giardiasis in the Mongolian Gerbil. Scandinavian Journal of Gastroenterology 1993; 28: 885-893
• 24 Tsuchiya H. Changes in Morphology of Giardia Canis as Affected by Diet. Experimental Biology and Medicine 1931; 28: 708-709
• 25 Bolbecher G, Dillitzer N, Brendieck-Worm C. Hrsg. Ganzheitliche Ernährung für Hund und Katze: individuell - typgerecht - natürlich. Stuttgart New York: Georg Thieme Verlag; 2020
• 26 Singer SM, Nash TE. The Role of Normal Flora in Giardia lamblia Infections in Mice. J INFECT DIS 2000; 181: 1510-1512