Briefing: Candidozyma (Candida) auris

Im Jahr 2023 wurde in Deutschland mit der Aufnahme des Nachweises von Candidozyma auris (früher: Candida auris) aus primär sterilen Materialien in das Infektionsschutzgesetz erstmals ein pathogener Pilz meldepflichtig. Im Jahr zuvor hatte bereits die WHO Candidozyma auris in die Kategorie „kritische Priorität“ eingestuft. In diesem Beitrag werden die besonderen Eigenschaften von Candidozyma auris, die zu dieser Aufmerksamkeit aus Public-Health-Sicht führen, zusammengefasst dargestellt.

Schlüsselwörter

Candidozyma auris - Candida auris - Echinocandine - Azol-Antimykotika - Screening - Amphotericin B - Infektionsschutz

• Literatur

• 1 Satoh K, Makimura K, Hasumi Y. et al. Candida auris sp. nov., a novel ascomycetous yeast isolated from the external ear canal of an inpatient in a Japanese hospital. Microbiol Immunol 2009; 53: 41-44
• 2 Liu F, Hu ZD, Zhao XM. et al. Phylogenomic analysis of the Candida auris-Candida haemuli clade and related taxa in the Metschnikowiaceae, and proposal of thirteen new genera, fifty-five new combinations and nine new species. Persoonia 2024; 52: 22-43
• 3 Lee WG, Shin JH, Uh Y. et al. First three reported cases of nosocomial fungemia caused by Candida auris. J Clin Microbiol 2011; 49: 3139-3142
• 4 Lockhart SR, Etienne KA, Vallabhaneni S. et al. Simultaneous Emergence of Multidrug-Resistant Candida auris on 3 Continents Confirmed by Whole-Genome Sequencing and Epidemiological Analyses. Clin Infect Dis 2017; 64: 134-140
• 5 Spruijtenburg B, Badali H, Abastabar M. et al. Confirmation of fifth Candida auris clade by whole genome sequencing. Emerg Microbes Infect 2022; 11: 2405-2411
• 6 Suphavilai C, Ko KKK, Lim KM. et al. Detection and characterisation of a sixth Candida auris clade in Singapore: a genomic and phenotypic study. Lancet Microbe 2024; 5: 100878
• 7 Chow NA, Munoz JF, Gade L. et al. Tracing the Evolutionary History and Global Expansion of Candida auris Using Population Genomic Analyses. mBio 2020; 11: e03364-19
• 8 Rhodes J, Fisher MC. Global epidemiology of emerging Candida auris. Curr Opin Microbiol 2019; 52: 84-89
• 9 Casadevall A, Kontoyiannis DP, Robert V. Environmental Candida auris and the Global Warming Emergence Hypothesis. mBio 2021; 12: e00360-21
• 10 Arora P, Singh P, Wang Y. et al. Environmental Isolation of Candida auris from the Coastal Wetlands of Andaman Islands, India. mBio 2021; 12: e03181-20
• 11 Yadav A, Jain K, Wang Y. et al. Candida auris on Apples: Diversity and Clinical Significance. mBio 2022; 13: e0051822
• 12 Yadav V, Heitman J. On Fruits and Fungi: A Risk of Antifungal Usage in Food Storage and Distribution in Driving Drug Resistance in Candida auris. mBio 2022; 13: e0073922
• 13 Yadav A, Wang Y, Jain K. et al. Candida auris in Dog Ears. J Fungi (Basel) 2023; 9: 720
• 14 Casadevall A, Kontoyiannis DP, Robert V. On the Emergence of Candida auris: Climate Change, Azoles, Swamps, and Birds. mBio 2019; 10: e01397-19
• 15 Irinyi L, Roper M, Malik R. et al. Finding a Needle in a Haystack - In Silico Search for Environmental Traces of Candida auris. Jpn J Infect Dis 2022; 75: 490-495
• 16 Lionakis MS, Chowdhary A. Candida auris Infections. N Engl J Med 2024; 391: 1924-1935
• 17 Chowdhary A, Sharma A. The lurking scourge of multidrug resistant Candida auris in times of COVID-19 pandemic. J Glob Antimicrob Resist 2020; 22: 175-176
• 18 Hamprecht A, Barber AE, Mellinghoff SC. et al. Candida auris in Germany and Previous Exposure to Foreign Healthcare. Emerg Infect Dis 2019; 25: 1763-1765
• 19 Hinrichs C, Wiese-Posselt M, Graf B. et al. Successful control of Candida auris transmission in a German COVID-19 intensive care unit. Mycoses 2022; 65: 643-649
• 20 Aldejohann AM, Martin R, Hecht J. et al. Rise in Candida Auris Cases and First Nosocomial Transmissions in Germany. Dtsch Arztebl Int 2023; 120: 447-478
• 21 Aldejohann AM, Hecht J, Martin R. et al. Zunahme von Candida auris in Deutschland im Jahr 2023. Epid Bull 2024; 18: 3-7
• 22 Plachouras D, Lotsch F, Kohlenberg A. et al. Candida auris: epidemiological situation, laboratory capacity and preparedness in the European Union and European Economic Area*, January 2018 to May 2019. Euro Surveill 2020; 25: 2000240
• 23 Kohlenberg A, Monnet DL, Plachouras D. et al. Increasing number of cases and outbreaks caused by Candida auris in the EU/EEA, 2020 to 2021. Euro Surveill 2022; 27: 2200846
• 24 European Center for Disease Prevention and Control. Survey on the epidemiological situation, laboratory capacity and preparedness for Candidozyma (Candida) auris, 2024. Stockholm: ECDC; 2025.
• 25 Lyman M, Forsberg K, Sexton DJ. et al. Worsening Spread of Candida auris in the United States, 2019 to 2021. Ann Intern Med 2023; 176: 489-495
• 26 Yadav SK, Himanshu D, Gupta P. et al. Multidrug-Resistant Candida in Bloodstream Infections: A Growing Concern in Indian Healthcare. Cureus 2025; 17: e85420
• 27 Prayag PS, Patwardhan S, Panchakshari S. et al. The Dominance of Candida auris: A Single-center Experience of 79 Episodes of Candidemia from Western India. Indian J Crit Care Med 2022; 26: 560-563
• 28 van Schalkwyk E, Mpembe RS, Thomas J. et al. Epidemiologic Shift in Candidemia Driven by Candida auris, South Africa, 2016–20171. Emerg Infect Dis 2019; 25: 1698-1707
• 29 Jones CR, Neill C, Borman AM. et al. The laboratory investigation, management, and infection prevention and control of Candida auris: a narrative review to inform the 2024 national guidance update in England. J Med Microbiol 2024; 73: 001820
• 30 Aldejohann AM, Wiese-Posselt M, Gastmeier P. et al. Expert recommendations for prevention and management of Candida auris transmission. Mycoses 2022; 65: 590-598
• 31 Aldejohann AM, Herz M, Martin R. et al. Emergence of resistant Candida glabrata in Germany. JAC Antimicrob Resist 2021; 3: dlab122
• 32 Siopi M, Leventaki S, Pachoulis I. et al. Evaluation of the MIC test strips for antifungal susceptibility testing of Candidozyma auris (Candida auris) using a representative international collection of isolates. J Clin Microbiol 2025; 63: e0039925
• 33 Cornely OA, Sprute R, Bassetti M. et al. Global guideline for the diagnosis and management of candidiasis: an initiative of the ECMM in cooperation with ISHAM and ASM. Lancet Infect Dis 2025; 25: e280-e293
• 34 Eyre DW, Sheppard AE, Madder H. et al. A Candida auris Outbreak and Its Control in an Intensive Care Setting. N Engl J Med 2018; 379: 1322-1331
• 35 Kumar A, Sachu A, Mohan K. et al. Simple low cost differentiation of Candida auris from Candida haemulonii complex using CHROMagar Candida medium supplemented with Pal's medium. Rev Iberoam Micol 2017; 34: 109-111
• 36 Verbund für Angewandte Hygiene (VAH). Newsletter. Accessed October 06, 2025 at: https://archive.newsletter2go.com/?n2g=7z87nwbr-3sawiflj-tuf
• 37 Brassington PJT, Klefisch FR, Graf B. et al. Genomic reconstruction of an azole-resistant Candida parapsilosis outbreak and the creation of a multi-locus sequence typing scheme: a retrospective observational and genomic epidemiology study. Lancet Microbe 2025; 6: 100949