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Semin Respir Crit Care Med
DOI: 10.1055/a-2531-1166
Review Article

Obstructive Sleep Apnea and Chronic Obstructive Pulmonary Disease Overlap Syndrome

Marta Marin-Oto
1   Respiratory Service, Hospital Clinico Universitario, Zaragoza, Spain
2   Precisión Medicine in Respiratory Deseases Program, Instituto Investigación Sanitaria Aragón, Zaragoza & CIBER Enfermedades Respiratorias, Madrid, Spain
3   Department of Medicine, University of Zaragoza, Zaragoza, Spain
,
David Sanz-Rubio
2   Precisión Medicine in Respiratory Deseases Program, Instituto Investigación Sanitaria Aragón, Zaragoza & CIBER Enfermedades Respiratorias, Madrid, Spain
,
José M. Marin
2   Precisión Medicine in Respiratory Deseases Program, Instituto Investigación Sanitaria Aragón, Zaragoza & CIBER Enfermedades Respiratorias, Madrid, Spain
3   Department of Medicine, University of Zaragoza, Zaragoza, Spain
4   Respiratory Service, Hospital Universitario Miguel Servet, Zaragoza, Spain
› Author Affiliations Funding M.M.-O. was supported by Instituto Salud Carlos III, Ministry of Health, Marid, Spain (PI12/02175, PI15/01940 and PI18/01524) and D.S.-R. was supported by Sara Borrell grant from the Instituto de Salud Carlos III, Ministry of Health, Madrid, Spain
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Abstract

The coexistence of chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA) in the same patients is defined as COPD/OSA overlap syndrome (OVL). OSA and sleep complaints are quite common among COPD patients and contribute to an increase in the risk of COPD exacerbation and mortality. Patients with OVL are more likely to develop cardiometabolic disease than patients with OSA or COPD alone. We must consider OSA as a treatable trait since the use of positive pressure ventilation reduces severe exacerbations, all-cause hospitalizations, and mortality in patients with COPD.

Keywords

chronic obstructive pulmonary disease - obstructive sleep apnea - overlap syndrome - positive pressure ventilation


Publication History

Article published online:
22 April 2025

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