The Correlation of Vitamin D Concentrations in Healthy Pregnant Women and Their Infants with Outcome Parameters

Abstract

Objective

The objective of this prospective study was to assess the concentration and impact of maternal 25(OH)D status on neonatal vitamin D concentrations and early neonatal outcomes in the newborns of mothers who did not take vitamin D supplements during pregnancy.

Methods and participants

The study is a cohort prospective study of the correlation of VD concentrations in mothers and their newborns. The study included 100 pairs.

Results

Only 16 mothers had a VD concentration in the reference interval (75–100 nmol/L), while 84 mothers had values less than 75 nmol/L (p<0.001). A significant difference in maternal VD concentration was determined in relation to tobacco consumption habits during pregnancy and placental condition (p<0.001). 95% of the neonates (95/100) of older, obese multigravida, who had hypovitaminosis D and inadequate exposure to sunshine, had normal VD concentrations (the mean=49.27 nmol/L) on the first day of life. The majority of the mothers gave birth to full-termnewborns with normal vitality scores and CRP and bilirubin levels in the reference interval.

Conclusion

The conclusion of this prospective study is that 84% of the healthy pregnant women had hypovitaminosis D. However 95% of their newborns were born full term, with normal anthropometric measurements, normal vitality scores, and normal VD concentrations. This study also confirmed that there is still no cause-and-effect association between hypovitaminosis D in pregnant women and their offspring with outcome parameters for both.

Keywords

infants - pregnancy - hypovitaminosis D - outcome

Publication History

Received: 30 August 2024

Accepted after revision: 10 February 2025

Article published online:
11 March 2025

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