Liver Neurobiology: Regulation of Liver Functions by the Nervous System

Boris Mravec; Maria Szantova

doi:10.1055/a-2562-2000

Seminars in Liver Disease, Inhaltsverzeichnis

Semin Liver Dis
DOI: 10.1055/a-2562-2000

Review Article

Liver Neurobiology: Regulation of Liver Functions by the Nervous System

Boris Mravec

¹Department of Physiology Faculty of Medicine, Comenius University, Bratislava, Slovakia

²Institute of Experimental Endocrinology, Biomedical Research Center, Slovak Academy of Sciences, Bratislava, Slovakia

,

Maria Szantova

³3rd Department of Internal Medicine, Faculty of Medicine, Comenius University, Bratislava, Slovakia

› Institutsangaben

Abstract

The nervous system plays an important role in the regulation of liver functions during physiological as well as pathological conditions. This regulatory effect is based on the processing of signals transmitted to the brain by sensory nerves innervating the liver tissue and other visceral organs and by humoral pathways transmitting signals from peripheral tissues and organs. Based on these signals, the brain modulates metabolism, detoxification, regeneration, repair, inflammation, and other processes occurring in the liver. The nervous system thus determines the functional and morphological characteristics of the liver. Liver innervation also mediates the influence of psychosocial factors on liver functions. The aim of this review is to describe complexity of bidirectional interactions between the brain and liver and to characterize the mechanisms and pathways through which the nervous system influences liver function during physiological conditions and maintains liver and systemic homeostasis.

Keywords

cholinergic anti-inflammatory pathway - sympathetic nervous system - sensory nerves - stress - vagus nerve

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Referenzen

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