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Thromb Haemost
DOI: 10.1055/a-2580-0107
Letter to the Editor

Elevated Protein S Provides Evidence against Hypoxia-Induced Hypercoagulation in Tibetan Highlanders with PHD2D4E;C127S Polymorphisms

Nishith M. Shrimali   *
1   Regional Centre for Biotechnology, National Capital Region Biotech Science Cluster, Faridabad, Haryana, India
,
Riya Ghosh   *
1   Regional Centre for Biotechnology, National Capital Region Biotech Science Cluster, Faridabad, Haryana, India
2   Manav Rachna International Institute of Research and Studies, Faridabad, Haryana, India
,
Kanchan Bhardwaj
1   Regional Centre for Biotechnology, National Capital Region Biotech Science Cluster, Faridabad, Haryana, India
2   Manav Rachna International Institute of Research and Studies, Faridabad, Haryana, India
,
Chorol Tsewang
3   Department of Surgery, Sonam Nurboo Memorial Hospital, Leh-Ladakh, Jammu and Kashmir, India
,
Tashi Thinlas
4   Department of Medicine, Sonam Nurboo Memorial Hospital, Leh-Ladakh, Jammu and Kashmir, India
,
Parvaiz Koul
5   Department of Internal and Pulmonary Medicine, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, Jammu and Kashmir, India
,
Josef T. Prchal
6   Department of Medicine, University of Utah School of Medicine and Huntsman Cancer Center and George E. Whalen Veteran's Administration Medical Center, Salt Lake City, Utah, United States
,
Prasenjit Guchhait
1   Regional Centre for Biotechnology, National Capital Region Biotech Science Cluster, Faridabad, Haryana, India
› Institutsangaben Funding This study was funded by grants: BT/PR22881 and BT/PR22985 from the Department of Biotechnology, Government of India to P.G.
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Author's Contribution

N.M.S. and R.G. designed and performed all experiments, collected samples from sea level, analyzed data, and wrote the manuscript. K.B. performed some assays. C.T., T.T., and P.K. collected high-altitude samples. P.K. provided conceptual inputs. J.T.P. conceptualized the study and wrote the manuscript. P.G. designed and supervised the study, conceptualized the approach, designed the experiments, analyzed the data, and wrote the manuscript. All authors read, edited, and approved the final manuscript.


* These authors contributed equally.




Publikationsverlauf

Eingereicht: 02. April 2025

Angenommen: 09. April 2025

Artikel online veröffentlicht:
01. Mai 2025

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