Rare Case of Squamous Cell Cancer – Mixed Neuroendocrine Neoplasm in the tubular Esophagus (MiNEN) discovered by Endoscopic Submucosal Dissection of the entire Tumor

Abstract

Background

Mixed neuroendocrine-non-neuroendocrine neoplasms (MiNENs) are rare in the gastrointestinal tract.

Case report

We report the case of a patient in whom complete endoscopic resection of a tumorous lesion in the tubular esophagus, initially diagnosed as squamous cell carcinoma (SCC) led to the diagnosis of SCC-MiNEN, which changed the patient´s treatment course.

Conclusion

With improvements in endoscopic techniques, we advocate resection of small malignant lesions in the gastrointestinal tract for both curative and diagnostic reasons.

Zusammenfassung

Hintergrund

Gemischte neuroendokrine/nicht-neuroendokrine Neoplasmen (MiNENs) sind im Gastrointestinaltrakt selten.

Fallbericht

Wir berichten über den Fall eines Patienten, bei dem die vollständige endoskopische Resektion einer tumorösen Läsion im tubulären Ösophagus, die ursprünglich als Plattenepithelkarzinom (PLECA) diagnostiziert wurde, zur Diagnose eines PLECA-MiNEN führte, was den Therapieverlauf des Patienten änderte.

Schlussfolgerung

Angesichts der Verbesserungen bei den endoskopischen Techniken befürworten wir die Resektion kleiner maligner Läsionen im Gastrointestinaltrakt sowohl aus kurativen als auch aus diagnostischen Gründen.

Keywords

MiNEN - mixed neuroendocrine-non-neuroendocrine neoplasm - squamous cell carcinoma (SCC) - neuroendocrine carcinoma (NEC) - endoscopic submucosal dissection (ESD) - Esophagus - neuroendocrine tumor (NET)

Schlüsselwörter

MiNEN - gemischtes neuroendokrin-nichtneuroendokrines Karzinom - neuroendokrines Karzinom (NEC) - neuroendokriner Tumor (NET) - Plattenepithelkarzinom (PLECA) - Ösophagus - Endoskopische Submukosadissektion (ESD)

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