Using the Cerebrovascular Time Constant to Assess Cerebral Perfusion in Neonates

Daisuke Uda; Masashi Zuiki; Mikito Ohta; Akio Yamano; Norihiro Iwata; Naoe Fujita; Kazunori Watanabe; Rika Mitsuno; Madoka Konishi; Eisuke Ichise; Kanae Hashiguchi; Daisuke Kinoshita; Tatsuji Hasegawa; Tomoko Iehara

doi:10.1055/a-2662-8394

American Journal of Perinatology, Table of Contents

Am J Perinatol
DOI: 10.1055/a-2662-8394

Original Article

Using the Cerebrovascular Time Constant to Assess Cerebral Perfusion in Neonates

Daisuke Uda

¹Department of Pediatrics, National Hospital Organization Maizuru Medical Center, Kyoto, Japan

²Department of Pediatrics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan

,

Masashi Zuiki

²Department of Pediatrics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan

,

Mikito Ohta

³Department of Neonatology, Japanese Red Cross Kyoto Daiichi Hospital, Kyoto, Japan

,

Akio Yamano

²Department of Pediatrics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan

,

Norihiro Iwata

²Department of Pediatrics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan

,

Naoe Fujita

¹Department of Pediatrics, National Hospital Organization Maizuru Medical Center, Kyoto, Japan

,

Kazunori Watanabe

²Department of Pediatrics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan

,

Rika Mitsuno

²Department of Pediatrics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan

,

Madoka Konishi

²Department of Pediatrics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan

,

Eisuke Ichise

¹Department of Pediatrics, National Hospital Organization Maizuru Medical Center, Kyoto, Japan

²Department of Pediatrics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan

,

Kanae Hashiguchi

²Department of Pediatrics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan

,

Daisuke Kinoshita

³Department of Neonatology, Japanese Red Cross Kyoto Daiichi Hospital, Kyoto, Japan

,

Tatsuji Hasegawa

²Department of Pediatrics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan

,

Tomoko Iehara

²Department of Pediatrics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan

› Author Affiliations

Abstract

Objective

This study aimed to investigate the relationship between the cerebrovascular time constant (Tau) and estimated cerebral perfusion pressure (CPPe) in neonates and clarify the normative reference data of Tau for different gestational ages.

Study Design

This multicenter, prospective study included infants with arterial lines who were admitted to neonatal intensive care units between December 2021 and May 2024. Tau and CPPe were calculated based on middle cerebral artery waveforms obtained using transcranial Doppler ultrasonography when clinicians collected arterial blood samples.

Results

A total of 432 samples were obtained from 127 infants with a median gestational age of 32 weeks (interquartile range [IQR]: 28–37 weeks) and a median birth weight of 1,566 g (IQR: 932–2,334 g). Tau demonstrated a significant correlation with CPPe across the following gestational age groups: ≤29 weeks, r = −0.49 and p < 0.001; 30 to 36 weeks, r = −0.61 and p < 0.001; and ≥37 weeks, r = −0.56 and p < 0.001. Despite this correlation, the median Tau was consistent across gestational ages, and the following normative reference values were observed: ≤29 weeks, 0.178 ± 0.046 seconds; 30 to 36 weeks, 0.186 ± 0.045 seconds; ≥ 37 weeks, 0.176 ± 0.037 seconds; and all weeks, 0.180 ± 0.044 seconds.

Conclusion

Tau may serve as an effective parameter for evaluating cerebral perfusion in neonates.

Key Points

Tau correlates with CPPe across gestational ages
The median Tau value was consistent at 0.18 seconds.
Tau is useful for cerebral perfusion evaluations.

Keywords

cerebral perfusion - cerebrovascular time constant - estimated cerebral perfusion pressure - neonates

Full Text

References

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