Update Mammakarzinom 2024 Teil 3 – Patientinnen mit fortgeschrittenen Stadien des Mammakarzinoms

Zusammenfassung

Mit den CDK4/6-Inhibitoren, den neuen PI3K/AKT-Kinase-Inhibitoren, den selektiven Östrogenrezeptor-Degradern (SERDs), den Antikörper-Wirkstoff-Konjugaten, den Immuntherapien und den PARP-Inhibitoren wurde die Therapielandschaft von Patientinnen mit fortgeschrittenem Mammakarzinom in den letzten Jahren deutlich zum Positiven verändert. CDK4/6-Inhibitoren, Trastuzumab-Deruxtecan und Sacituzumab-Govitecan haben zudem alle einen signifikanten Gesamtüberlebensvorteil gegenüber konventioneller Chemotherapie nachgewiesen. Weitere Substanzen zeigen ebenfalls vielversprechende Daten, die hoffen lassen, dass in naher Zukunft weitere Analysen mit einem Gesamtüberlebensvorteil vorliegen. Die Geschwindigkeit der Studiendurchführung hat deutlich zugenommen, sodass die Kongresse zusammen mit den Fachzeitschriften eine stetige Quelle neuer Informationen bieten. Diese Übersichtsarbeit fasst die jüngsten Veröffentlichungen und Kongresspräsentationen über die Behandlung von Patientinnen mit fortgeschrittenen Stadien einer Mammakarzinomerkrankung zusammen.

Abstract

The use of CDK4/6 inhibitors, the new PI3K/AKT-kinase inhibitors, selective estrogen receptor-degraders (SERDs), antibody-drug conjugates, immune therapies and PARP inhibitors in recent years has resulted in a marked change in the therapy landscape for patients with advanced stage breast cancer. CDK4/6 inhibitors, trastuzumab deruxtecan, and sacituzumab govitecan have all been shown to provide significant overall survival benefits compared to conventional chemotherapy. Other substances are also showing promising results and hold out the hope that further analysis of the overall survival benefits will be available in the near future. The speed at which studies are now being carried out has markedly increased, and conferences and specialist journals are now constant sources of new information. This review summarizes the most recent publications and conference presentations on the treatment of patients with advanced stage breast cancer.

Schlüsselwörter

Mammakarzinom - Mammakarzinom im fortgeschrittenen Stadium - klinische Studien - Prognose

Keywords

breast cancer - advanced breast cancer - clinical studies - prognosis

Publikationsverlauf

Eingereicht: 20. November 2024

Angenommen nach Revision: 07. Dezember 2024

Artikel online veröffentlicht:
17. Dezember 2025

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