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Horm Metab Res 2025; 57(11): 617-618
DOI: 10.1055/a-2731-3649
Editorial

Metabolism and Aging – Charting New Frontiers in Mechanistic Understanding and Therapeutic Innovation

Authors

  • Charlotte Steenblock 

    1   Department of Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany

  • Roman N. Rodionov

    1   Department of Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany

  • Richard Siow

    2   School of Cardiovascular and Metabolic Medicine and Sciences, Faculty of Life Sciences & Medicine, King’s College London, London, UK (Ringgold ID: RIN39063)

  • Stefan R. Bornstein

    1   Department of Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany
    2   School of Cardiovascular and Metabolic Medicine and Sciences, Faculty of Life Sciences & Medicine, King’s College London, London, UK (Ringgold ID: RIN39063)
    3   Department of Endocrinology, Diabetology and Clinical Nutrition, University Hospital Zurich (USZ) and University of Zurich (UZH), Zurich, Switzerland (Ringgold ID: RIN39063)
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Dear Readers

Aging is the central risk factor for nearly all chronic diseases that threaten modern societies, such as cardiovascular disease, diabetes, neurodegeneration, cancer, and frailty. As the world’s population ages at an unprecedented rate, the imperative to understand the mechanisms that link metabolic pathways to aging, and to translate this knowledge into actionable therapies, has never been more urgent. In this special issue of Hormone and Metabolic Research on “Metabolism & Aging”, we present seven articles that collectively illuminate the molecular crosstalk between the metabolism and the aging process, and showcase emerging strategies for mitigating age-associated diseases.



Publication History

Article published online:
21 November 2025

© 2025. Thieme. All rights reserved.

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  • References

  • 1 Jarzebska N, Bornstein SR, Tselmin S. et al. Asymmetric dimethylarginine: a never-aging story. Horm Metab Res 2025; 57: 619-625
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  • 2 Walther R, Singh B, Yin X. et al. Proteomic profiling of age-related proteins following extracorporeal apheresis. Horm Metab Res 2025; 57: 626-631
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  • 3 Jarzebska N, Rodionov RN, Voit-Bak K. et al. Neutrophil extracellular traps (NETs) as a potential target for anti-aging: role of therapeutic apheresis. Horm Metab Res 2025; 57: 632-638
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  • 4 Castillo-Aleman Y, Villegas-Valverde C, Ventura-Carmenate Y. et al. Modulating systemic immune-inflammatory indices via double filtration plasmapheresis: implications for aging and low-grade inflammation. Horm Metab Res 2025; 57: 639-645
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  • 5 Steenblock C, Walther R, Kok Y. et al. Single-center study of therapeutic apheresis in 24 male patients from the MENA region: reduction of lipids, inflammatory markers, autoantibodies, and implications for fatigue, genetics, and aging. Horm Metab Res 2025; 57: 646-652
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  • 6 Omurzakova U, Breidert M, Donner M. et al. Proteomic signatures and blood ATP levels as markers of empagliflozin efficacy in diabetes mellitus type 2 and heart failure. Horm Metab Res 2025; 57: 653-661
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  • 7 Oikonomakos I, Siow R, Bornstein SR. et al. The role of growth hormone-releasing hormone and the hypothalamic–pituitary–somatotropic axis in aging: potential therapeutic applications and risks. Horm Metab Res 2025; 57: 662-667
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