PDF herunterladen
Semin Thromb Hemost
DOI: 10.1055/a-2734-3124
Correspondence

Research Design Concerns in a TriNetX Analysis of Venous Thromboembolism in Pediatric Cystic Fibrosis Patients

Autor*innen

  • Chee-Seng Lee

    1   Department of Pediatrics, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan
    2   Department of Pediatrics, National Taiwan University Children's Hospital, Taipei, Taiwan

  • Joshua Wang 

    3   Department of Research, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan
    4   School of Biomedical Sciences, Queensland University of Technology, Brisbane, Australia
Weitere Informationen
   Lizenzen und Reprints

Dear Editor,

We enjoyed reading Trocchia et al's[1] recently published TriNetX-based study of pediatric cystic fibrosis (CF) patients. The authors found significant associations between venous thromboembolism (VTE) and an increased risk of various gastrointestinal disorders. While TriNetX allows users to analyze large amounts of aggregate patient data,[2] there is a risk of research design oversights when utilizing the automated analysis tools on the platform.[3] In this letter, we analyze some potential limitations of the Trocchia et al study.



Publikationsverlauf

Eingereicht: 13. Oktober 2025

Angenommen: 29. Oktober 2025

Accepted Manuscript online:
30. Oktober 2025

Artikel online veröffentlicht:
10. November 2025

© 2025. Thieme. All rights reserved.

Thieme Medical Publishers, Inc.
333 Seventh Avenue, 18th Floor, New York, NY 10001, USA