Subscribe to RSS
DOI: 10.1055/a-2794-9360
Device Therapy in Heart Failure
Authors
Abstract
Heart failure is a leading cause of morbidity and mortality worldwide. Patients with acute heart failure, cardiogenic shock, and end-stage chronic heart failure may benefit from a variety of device therapies. These devices may serve as a rescue, a bridge to recovery, a bridge to further therapy, or heart replacement therapy. The appropriate utilization of these devices is an ongoing area of research. In this review, we provide an overview of the available literature for device therapy in both the acute and chronic heart failure settings. We will present landmark trials, guidelines, and ongoing areas of research. Our goal is to aid in the appropriate selection of both devices and patients who will benefit.
Keywords
cardiogenic shock - acute heart failure - chronic heart failure - temporary mechanical circulatory support - left ventricular assist device - cardiac resynchronization therapy - implantable cardioverter-defibrillatorPublication History
Received: 14 January 2026
Accepted: 21 January 2026
Article published online:
06 February 2026
© 2026. International College of Angiology. This article is published by Thieme.
Thieme Medical Publishers, Inc.
333 Seventh Avenue, 18th Floor, New York, NY 10001, USA
-
References
- 1 Heidenreich PA, Bozkurt B, Aguilar D. et al. 2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure: Executive summary: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation 2022; 145 (18) e876-e894
- 2 Writing Committee Members. HF STATS 2025: Heart Failure Epidemiology and Outcomes Statistics An Updated 2025 Report from the Heart Failure Society of America. J Card Fail 2025; S1071-9164 (25)00326-4
- 3 Virani SS, Alonso A, Aparicio HJ. et al; American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee. Heart Disease and Stroke Statistics-2021 Update: A report from the American Heart Association. Circulation 2021; 143 (08) e254-e743
- 4 Miller-Davis C, Marden S, Leidy NK. The New York Heart Association Classes and functional status: What are we really measuring?. Heart Lung 2006; 35 (04) 217-224
- 5 Behnoush AH, Khalaji A, Naderi N, Ashraf H, von Haehling S. ACC/AHA/HFSA 2022 and ESC 2021 guidelines on heart failure comparison. ESC Heart Fail 2023; 10 (03) 1531-1544
- 6 Baran DA, Grines CL, Bailey S. et al. SCAI clinical expert consensus statement on the classification of cardiogenic shock: This document was endorsed by the American College of Cardiology (ACC), the American Heart Association (AHA), the Society of Critical Care Medicine (SCCM), and the Society of Thoracic Surgeons (STS) in April 2019. Catheter Cardiovasc Interv 2019; 94 (01) 29-37
- 7 Naidu SS, Baran DA, Jentzer JC. et al. SCAI SHOCK Stage Classification Expert Consensus Update: A review and incorporation of validation studies: This statement was endorsed by the American College of Cardiology (ACC), American College of Emergency Physicians (ACEP), American Heart Association (AHA), European Society of Cardiology (ESC) Association for Acute Cardiovascular Care (ACVC), International Society for Heart and Lung Transplantation (ISHLT), Society of Critical Care Medicine (SCCM), and Society of Thoracic Surgeons (STS) in December 2021. J Am Coll Cardiol 2022; 79 (09) 933-946
- 8 Møller JE, Thiele H, Morrow D, Kjærgaard J, Hassager C. Mechanical circulatory support: When, how, and for whom. Eur Heart J 2025; 46 (16) 1480-1492
- 9 Burkhoff D, Sayer G, Doshi D, Uriel N. Hemodynamics of mechanical circulatory support. J Am Coll Cardiol 2015; 66 (23) 2663-2674
- 10 Frank O. Zur Dynamik des Herzmuskels. J Biol 1895; 32: 370-447 . [Translation from German: Chapman CP, Wasserman EB. On the dynamics of cardiac muscle. Am Heart J 1959;58:282–317]
- 11 Starling EH. Linacre Lecture on the Law of the Heart. London, England: Longmans; 1918
- 12 Arrigo M, Jessup M, Mullens W. et al. Acute heart failure. Nat Rev Dis Primers 2020; 6 (01) 16
- 13 Njoroge JN, Teerlink JR. Pathophysiology and therapeutic approaches to acute decompensated heart failure. Circ Res 2021; 128 (10) 1468-1486
- 14 Hollenberg SM, Warner Stevenson L, Ahmad T. et al. 2019 ACC Expert Consensus Decision Pathway on Risk Assessment, Management, and Clinical Trajectory of Patients Hospitalized With Heart Failure: A report of the American College of Cardiology Solution Set Oversight Committee. J Am Coll Cardiol 2019; 74 (15) 1966-2011 ( Erratum in: J Am Coll Cardiol. 2020 Jan 7;75(1):132 . PMID: 31526538)
- 15 Yancy CW, Jessup M, Bozkurt B. et al; American College of Cardiology Foundation, American Heart Association Task Force on Practice Guidelines. 2013 ACCF/AHA guideline for the management of heart failure: A report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol 2013; 62 (16) e147-e239
- 16 Saxena A, Garan AR, Kapur NK. et al. Value of hemodynamic monitoring in patients with cardiogenic shock undergoing mechanical circulatory support. Circulation 2020; 141 (14) 1184-1197
- 17 Squara P, Hollenberg S, Payen D. Reconsidering vasopressors for cardiogenic shock: Everything should be made as simple as possible, but not simpler. Chest 2019; 156 (02) 392-401
- 18 Geller BJ, Sinha SS, Kapur NK. et al; American Heart Association Acute Cardiac Care and General Cardiology Committee of the Council on Clinical Cardiology; Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitation; Council on Cardiovascular Radiology and Intervention; Council on Cardiovascular and Stroke Nursing; Council on Peripheral Vascular Disease; and Council on Cardiovascular Surgery and Anesthesia. Escalating and de-escalating temporary mechanical circulatory support in cardiogenic shock: A scientific statement from the American Heart Association. Circulation 2022; 146 (06) e50-e68
- 19 Obradovic D, Freund A, Feistritzer HJ. et al. Temporary mechanical circulatory support in cardiogenic shock. Prog Cardiovasc Dis 2021; 69: 35-46
- 20 Thiele H, Zeymer U, Neumann FJ. et al; Intraaortic Balloon Pump in Cardiogenic Shock II (IABP-SHOCK II) Trial Investigators. Intra-aortic balloon counterpulsation in acute myocardial infarction complicated by cardiogenic shock (IABP-SHOCK II): Final 12 month results of a randomised, open-label trial. Lancet 2013; 382 (9905): 1638-1645
- 21 Ahmad Y, Sen S, Shun-Shin MJ. et al. Intra-aortic balloon pump therapy for acute myocardial infarction: A meta-analysis. JAMA Intern Med 2015; 175 (06) 931-939 ( Erratum in: JAMA Intern Med. 2018 Aug 1;178(8):1144 . PMID: 25822657)
- 22 den Uil CA, Van Mieghem NMB, B. Bastos M. et al. Primary intra-aortic balloon support versus inotropes for decompensated heart failure and low output: A randomised trial. EuroIntervention 2019; 15 (07) 586-593
- 23 Morici N, Sacco A, Frea S. et al; Altshock-2 Investigators. Early intra-aortic balloon support for heart failure-related cardiogenic shock: A randomized clinical trial. J Am Coll Cardiol 2025; 85 (16) 1587-1597
- 24 Annamalai SK, Buiten L, Esposito ML. et al. Acute hemodynamic effects of intra-aortic balloon counterpulsation pumps in advanced heart failure. J Card Fail 2017; 23 (08) 606-614
- 25 Morici N, Marini C, Sacco A. et al. Intra-aortic balloon pump for acute-on-chronic heart failure complicated by cardiogenic shock. J Card Fail 2022; 28 (07) 1202-1216
- 26 Glazier JJ, Kaki A. The Impella device: Historical background, clinical applications and future directions. Int J Angiol 2019; 28 (02) 118-123
- 27 Seyfarth M, Sibbing D, Bauer I. et al. A randomized clinical trial to evaluate the safety and efficacy of a percutaneous left ventricular assist device versus intra-aortic balloon pumping for treatment of cardiogenic shock caused by myocardial infarction. J Am Coll Cardiol 2008; 52 (19) 1584-1588
- 28 Ouweneel DM, Eriksen E, Sjauw KD. et al. Percutaneous mechanical circulatory support versus intra-aortic balloon pump in cardiogenic shock after acute myocardial infarction. J Am Coll Cardiol 2017; 69 (03) 278-287
- 29 Bochaton T, Huot L, Elbaz M. et al; IMPELLA-STIC investigators. Mechanical circulatory support with the Impella® LP5.0 pump and an intra-aortic balloon pump for cardiogenic shock in acute myocardial infarction: The IMPELLA-STIC randomized study. Arch Cardiovasc Dis 2020; 113 (04) 237-243
- 30 Xenitopoulou MP, Ziampa K, Evangeliou AP, Tzikas S, Vassilikos V. Percutaneous mechanical circulatory support in acute heart failure complicated with cardiogenic shock. J Clin Med 2024; 13 (09) 2642
- 31 Iannaccone M, Albani S, Giannini F. et al. Short term outcomes of Impella in cardiogenic shock: A review and meta-analysis of observational studies. Int J Cardiol 2021; 324: 44-51
- 32 Jonna S, Olaizola G, Raavi L. et al. Impella 5.5 as heart transplant bridge facilitated rehabilitation and improves post-transplant outcomes: Retrospective cohort study. ASAIO J 2026; 72 (01) 49-55
- 33 Seese L, Hickey G, Keebler ME. et al. Direct bridging to cardiac transplantation with the surgically implanted Impella 5.0 device. Clin Transplant 2020; 34 (03) e13818
- 34 Abraham J, Anderson M, Silvestry S. et al. Outcomes of surgically implanted impella microaxial flow pumps in heart failure-related cardiogenic shock. J Card Fail 2025; S1071-9164 (25)00148-4
- 35 John KJ, Hernandez-Montfort J, Kanwar MK. et al; Cardiogenic Shock Working Group. Utilization and outcomes of temporary percutaneous right ventricular assist devices in cardiogenic shock. ASAIO J 2025; 71 (05) 379-386
- 36 Pappalardo F, Scandroglio AM, Latib A. Full percutaneous biventricular support with two Impella pumps: The Bi-Pella approach. ESC Heart Fail 2018; 5 (03) 368-371
- 37 Tschöpe C, Van Linthout S, Klein O. et al. Mechanical unloading by fulminant myocarditis: LV-IMPELLA, ECMELLA, BI-PELLA, and PROPELLA concepts. J Cardiovasc Transl Res 2019; 12 (02) 116-123
- 38 Tominaga Y, Toda K, Miyagawa S. et al. Total percutaneous biventricular assist device implantation for fulminant myocarditis. J Artif Organs 2021; 24 (02) 254-257
- 39 Varian K, Xu WD, Lin W. et al. Minimally invasive biventricular mechanical circulatory support with Impella pumps as a bridge to heart transplantation: A first-in-the-world case report. ESC Heart Fail 2019; 6 (03) 552-554
- 40 Kar B, Gregoric ID, Basra SS, Idelchik GM, Loyalka P. The percutaneous ventricular assist device in severe refractory cardiogenic shock. J Am Coll Cardiol 2011; 57 (06) 688-696
- 41 Burkhoff D, Cohen H, Brunckhorst C, O'Neill WW. TandemHeart Investigators Group. A randomized multicenter clinical study to evaluate the safety and efficacy of the TandemHeart percutaneous ventricular assist device versus conventional therapy with intraaortic balloon pumping for treatment of cardiogenic shock. Am Heart J 2006; 152 (03) 469.e1-469.e8
- 42 Thiele H, Sick P, Boudriot E. et al. Randomized comparison of intra-aortic balloon support with a percutaneous left ventricular assist device in patients with revascularized acute myocardial infarction complicated by cardiogenic shock. Eur Heart J 2005; 26 (13) 1276-1283
- 43 Megaly M, Gandolfo C, Zakhour S. et al. Utilization of TandemHeart in cardiogenic shock: Insights from the THEME registry. Catheter Cardiovasc Interv 2023; 101 (04) 756-763
- 44 Kapur NK, Paruchuri V, Jagannathan A. et al. Mechanical circulatory support for right ventricular failure. JACC Heart Fail 2013; 1 (02) 127-134
- 45 Koziol KJ, Isath A, Rao S. et al. Extracorporeal membrane oxygenation (VA-ECMO) in management of cardiogenic shock. J Clin Med 2023; 12 (17) 5576
- 46 Tonna JE, Boonstra PS, MacLaren G. et al; Extracorporeal Life Support Organization (ELSO) Member Centers Group. Extracorporeal Life Support Organization Registry International Report 2022: 100,000 Survivors. ASAIO J 2024; 70 (02) 131-143
- 47 Alba AC, Foroutan F, Buchan TA. et al. Mortality in patients with cardiogenic shock supported with VA ECMO: A systematic review and meta-analysis evaluating the impact of etiology on 29,289 patients. J Heart Lung Transplant 2021; 40 (04) 260-268
- 48 Zeymer U, Freund A, Hochadel M. et al. Venoarterial extracorporeal membrane oxygenation in patients with infarct-related cardiogenic shock: An individual patient data meta-analysis of randomised trials. Lancet 2023; 402 (10410): 1338-1346
- 49 Thiele H, Møller JE, Henriques JPS. et al; MCS Collaborator Scientific Group. Temporary mechanical circulatory support in infarct-related cardiogenic shock: an individual patient data meta-analysis of randomised trials with 6-month follow-up. Lancet 2024; 404 (10457): 1019-1028 ( Erratum in: Lancet. 2024 Sep 28;404(10459):1198 . PMID: 39236726)
- 50 Thiele H, Zeymer U, Akin I. et al; ECLS-SHOCK Investigators. Extracorporeal life support in infarct-related cardiogenic shock. N Engl J Med 2023; 389 (14) 1286-1297
- 51 Ostadal P, Rokyta R, Karasek J. et al; ECMO-CS Investigators. Extracorporeal membrane oxygenation in the therapy of cardiogenic shock: 1-year outcomes of the multicentre, randomized ECMO-CS trial. Eur J Heart Fail 2025; 27 (01) 30-36
- 52 Burgos LM, Seoane L, Diez M. et al. Multiparameters associated to successful weaning from VA ECMO in adult patients with cardiogenic shock or cardiac arrest: Systematic review and meta-analysis. Ann Card Anaesth 2023; 26 (01) 4-11
- 53 Russo JJ, Aleksova N, Pitcher I. et al. Left ventricular unloading during extracorporeal membrane oxygenation in patients with cardiogenic shock. J Am Coll Cardiol 2019; 73 (06) 654-662
- 54 Gandhi KD, Moras EC, Niroula S. et al. Left ventricular unloading with Impella versus IABP in patients with VA-ECMO: A systematic review and meta-analysis. Am J Cardiol 2023; 208: 53-59
- 55 Baldetti L, Gramegna M, Beneduce A. et al. Strategies of left ventricular unloading during VA-ECMO support: A network meta-analysis. Int J Cardiol 2020; 312: 16-21
- 56 Phillip R, Howard J, Hawamdeh H, Tribble T, Gurley J, Saha S. Left atrial veno-arterial extracorporeal membrane oxygenation case series: A single-center experience. J Surg Res 2023; 281: 238-244
- 57 Li Y, Yan S, Gao S. et al. Effect of an intra-aortic balloon pump with venoarterial extracorporeal membrane oxygenation on mortality of patients with cardiogenic shock: A systematic review and meta-analysis†. Eur J Cardiothorac Surg 2019; 55 (03) 395-404
- 58 Nishi T, Ishii M, Tsujita K. et al. Outcomes of venoarterial extracorporeal membrane oxygenation plus intra-aortic balloon pumping for treatment of acute myocardial infarction complicated by cardiogenic shock. J Am Heart Assoc 2022; 11 (07) e023713
- 59 Huang D, Xu A, Guan Q, Qin J, Zhang C. Venoarterial extracorporeal membrane oxygenation with intra-aortic balloon pump for postcardiotomy cardiogenic shock: A systematic review and meta-analysis. Perfusion 2023; 38 (01) 142-149
- 60 Fiorelli F, Panoulas V. Impella as unloading strategy during VA-ECMO: Systematic review and meta-analysis. Rev Cardiovasc Med 2021; 22 (04) 1503-1511
- 61 Bhatia K, Jain V, Hendrickson MJ. et al. Meta-analysis comparing venoarterial extracorporeal membrane oxygenation with or without Impella in patients with cardiogenic shock. Am J Cardiol 2022; 181: 94-101
- 62 Iannaccone M, Venuti G, di Simone E. et al. Comparison of ECMO vs ECpella in patients with non-post-pericardiotomy cardiogenic shock: An updated meta-analysis. Cardiovasc Revasc Med 2022; 40: 134-141
- 63 Cappannoli L, Galli M, Zito A. et al. Venoarterial extracorporeal membrane oxygenation (VA-ECMO) with vs. without left ventricular unloading by Impella: a systematic review and meta-analysis. Eur Heart J Qual Care Clin Outcomes 2023; 9 (04) 358-366
- 64 Farina J, Erriquez A, Campo G. et al. Combined use of intra-aortic balloon pump and impella in cardiogenic shock: A systematic review. Cardiovasc Revasc Med 2024; 67: 96-102
- 65 Ostrominski JW, DeFilippis EM, Bansal K. et al. Contemporary American and European Guidelines for heart failure management: JACC: Heart Failure Guideline Comparison. JACC Heart Fail 2024; 12 (05) 810-825
- 66 McDonagh TA, Metra M, Adamo M. et al; Authors/Task Force Members, ESC Scientific Document Group. 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: Developed by the Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC). With the special contribution of the Heart Failure Association (HFA) of the ESC. Eur J Heart Fail 2022; 24 (01) 4-131
- 67 Heidenreich PA, Bozkurt B, Aguilar D. et al; ACC/AHA Joint Committee Members. 2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure: A report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation 2022; 145 (18) e895-e1032 ( Erratumin: Circulation. 2022 May 3;145(18):e1033 Doi: 10.1161/CIR.0000000000001073. Erratum in: Circulation. 2022 Sep 27;146(13):e185 Doi: 10.1161/CIR.0000000000001097. Erratum in: Circulation. 2023 Apr 4;147(14):e674 Doi:10.1161/CIR.0000000000001142. PMID: 35363499)
- 68 Myerburg RJ, Kessler KM, Castellanos A. Sudden cardiac death. Structure, function, and time-dependence of risk. Circulation 1992; 85 (1 Suppl): I2-I10
- 69 Moss AJ, Hall WJ, Cannom DS. et al; Multicenter Automatic Defibrillator Implantation Trial Investigators. Improved survival with an implanted defibrillator in patients with coronary disease at high risk for ventricular arrhythmia. N Engl J Med 1996; 335 (26) 1933-1940
- 70 Greenberg H, Case RB, Moss AJ, Brown MW, Carroll ER, Andrews ML. MADIT-II Investigators. Analysis of mortality events in the Multicenter Automatic Defibrillator Implantation Trial (MADIT-II). J Am Coll Cardiol 2004; 43 (08) 1459-1465
- 71 Bardy GH, Lee KL, Mark DB. et al; Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT) Investigators. Amiodarone or an implantable cardioverter-defibrillator for congestive heart failure. N Engl J Med 2005; 352 (03) 225-237 ( Erratum in: N Engl J Med. 2005 May 19;352(20):2146. PMID: 15659722)
- 72 Kadish A, Dyer A, Daubert JP. et al; Defibrillators in Non-Ischemic Cardiomyopathy Treatment Evaluation (DEFINITE) Investigators. Prophylactic defibrillator implantation in patients with nonischemic dilated cardiomyopathy. N Engl J Med 2004; 350 (21) 2151-2158
- 73 Køber L, Thune JJ, Nielsen JC. et al; DANISH Investigators. Defibrillator implantation in patients with nonischemic systolic heart failure. N Engl J Med 2016; 375 (13) 1221-1230
- 74 Al-Khatib SM, Fonarow GC, Joglar JA. et al. Primary prevention implantable cardioverter defibrillators in patients with nonischemic cardiomyopathy: A meta-analysis. JAMA Cardiol 2017; 2 (06) 685-688
- 75 Minami Y, Kikuchi N, Shiga T, Suzuki A, Shoda M, Hagiwara N. Incidence and predictors of early and late sudden cardiac death in hospitalized Japanese patients with new-onset systolic heart failure. J Arrhythm 2021; 37 (05) 1148-1155
- 76 Curtain JP, Docherty KF, Jhund PS. et al. Effect of dapagliflozin on ventricular arrhythmias, resuscitated cardiac arrest, or sudden death in DAPA-HF. Eur Heart J 2021; 42 (36) 3727-3738
- 77 Yehya A, Lopez J, Sauer AJ. et al. Revisiting ICD therapy for primary prevention in patients with heart failure and reduced ejection fraction. JACC Heart Fail 2025; 13 (01) 1-13
- 78 Palmiero G, Florio MT, Rubino M, Nesti M, Marchel M, Russo V. Cardiac resynchronization therapy in patients with heart failure: What is new?. Heart Fail Clin 2021; 17 (02) 289-301
- 79 Choi AJ, Thomas SS, Singh JP. Cardiac resynchronization therapy and implantable cardioverter defibrillator therapy in advanced heart failure. Heart Fail Clin 2016; 12 (03) 423-436
- 80 Abraham WT, Fisher WG, Smith AL. et al; MIRACLE Study Group. Multicenter InSync Randomized Clinical Evaluation. Cardiac resynchronization in chronic heart failure. N Engl J Med 2002; 346 (24) 1845-1853
- 81 Cleland JG, Daubert JC, Erdmann E. et al; Cardiac Resynchronization-Heart Failure (CARE-HF) Study Investigators. The effect of cardiac resynchronization on morbidity and mortality in heart failure. N Engl J Med 2005; 352 (15) 1539-1549
- 82 Moss AJ, Hall WJ, Cannom DS. et al; MADIT-CRT Trial Investigators. Cardiac-resynchronization therapy for the prevention of heart-failure events. N Engl J Med 2009; 361 (14) 1329-1338
- 83 Tang AS, Wells GA, Talajic M. et al; Resynchronization-Defibrillation for Ambulatory Heart Failure Trial Investigators. Cardiac-resynchronization therapy for mild-to-moderate heart failure. N Engl J Med 2010; 363 (25) 2385-2395
- 84 Glikson M, Nielsen JC, Kronborg MB. et al; ESC Scientific Document Group. 2021 ESC Guidelines on cardiac pacing and cardiac resynchronization therapy. Eur Heart J 2021; 42 (35) 3427-3520 ( Erratum in: Eur Heart J. 2022 May 1;43(17):1651 . PMID: 34455430)
- 85 Berardi C, Bravo CA, Li S. et al. The history of durable left ventricular assist devices and comparison of outcomes: HeartWare, HeartMate II, HeartMate 3, and the future of mechanical circulatory support. J Clin Med 2022; 11 (07) 2022
- 86 Rose EA, Gelijns AC, Moskowitz AJ. et al; Randomized Evaluation of Mechanical Assistance for the Treatment of Congestive Heart Failure (REMATCH) Study Group. Long-term use of a left ventricular assist device for end-stage heart failure. N Engl J Med 2001; 345 (20) 1435-1443
- 87 Long JW, Kfoury AG, Slaughter MS. et al. Long-term destination therapy with the HeartMate XVE left ventricular assist device: Improved outcomes since the REMATCH study. Congest Heart Fail 2005; 11 (03) 133-138
- 88 Miller LW, Pagani FD, Russell SD. et al; HeartMate II Clinical Investigators. Use of a continuous-flow device in patients awaiting heart transplantation. N Engl J Med 2007; 357 (09) 885-896
- 89 Slaughter MS, Rogers JG, Milano CA. et al; HeartMate II Investigators. Advanced heart failure treated with continuous-flow left ventricular assist device. N Engl J Med 2009; 361 (23) 2241-2251 ( Erratum in: N Engl J Med. 2018 Aug 16;379(7):697 . PMID: 19920051)
- 90 Aaronson KD, Slaughter MS, Miller LW. et al; HeartWare Ventricular Assist Device (HVAD) Bridge to Transplant ADVANCE Trial Investigators. Use of an intrapericardial, continuous-flow, centrifugal pump in patients awaiting heart transplantation. Circulation 2012; 125 (25) 3191-3200
- 91 Slaughter MS, Pagani FD, McGee EC. et al; HeartWare Bridge to Transplant ADVANCE Trial Investigators. HeartWare ventricular assist system for bridge to transplant: Combined results of the bridge to transplant and continued access protocol trial. J Heart Lung Transplant 2013; 32 (07) 675-683
- 92 Mehra MR, Goldstein DJ, Uriel N. et al; MOMENTUM 3 Investigators. Two-year outcomes with a magnetically levitated cardiac pump in heart failure. N Engl J Med 2018; 378 (15) 1386-1395
- 93 Karem S, Malyala RSR, Saha S. Left ventricular assist device in the management of heart failure: A single-center experience. Int J Angiol 2025; 34 (03) 220-225
- 94 Molina EJ, Shah P, Kiernan MS. et al. The Society of Thoracic Surgeons Intermacs 2020 Annual Report. Ann Thorac Surg 2021; 111 (03) 778-792
- 95 McNamara N, Narroway H, Williams M. et al. Contemporary outcomes of continuous-flow left ventricular assist devices-a systematic review. Ann Cardiothorac Surg 2021; 10 (02) 186-208
- 96 Khoufi EAA. Outcomes of left ventricular assist devices as destination therapy: A systematic review with meta-analysis. Life (Basel) 2025; 15 (01) 53
- 97 Theochari CA, Michalopoulos G, Oikonomou EK. et al. Heart transplantation versus left ventricular assist devices as destination therapy or bridge to transplantation for 1-year mortality: A systematic review and meta-analysis. Ann Cardiothorac Surg 2018; 7 (01) 3-11
- 98 Zhang B, Guo S, Ning J, Li Y, Liu Z. Continuous-flow left ventricular assist device versus orthotopic heart transplantation in adults with heart failure: A systematic review and meta-analysis. Ann Cardiothorac Surg 2021; 10 (02) 209-220
- 99 Kirschner M, Topkara VK, Sun J. et al. Comparing 3-year survival and readmissions between HeartMate 3 and heart transplant as primary treatment for advanced heart failure. J Thorac Cardiovasc Surg 2025; 169 (01) 148-159.e3
- 100 Daneshmand MA, Bishawi M, Milano CA, Schroder JN. The HeartMate 6. ASAIO J 2020; 66 (03) e46-e49
- 101 Breda JR, Gergis R, Ahmed Z, Loebe M. Right-sided heart reperfusion (“Berlin bridge technique”) for right ventricle support during left ventricular assist device (LVAD) implantation. JTCVS Tech 2022; 13: 115-118
- 102 Lorente-Ros M, Husain MS, Pinilla-Vera M. et al. Clinical impact of an upfront RVAD strategy in HeartMate 3 LVAD recipients with severe early right ventricular failure requiring temporary mechanical support. JHLT Open 2025; 10: 100388
- 103 Oliveros E, Brailovsky Y, Aggarwal V. Overview of options for mechanical circulatory support Interv Cardiol Clin 2021; 10 (02) 147-156 https://pubmed.ncbi.nlm.nih.gov/33745665/
- 104 Southerland KW, Milano CA. Heart transplantation after left ventricular assist device Oper Tech Thorac Cardiovasc Surg 2014; 19 (1): 47-63