Neuropediatrics 2008; 39(3): 176-178
DOI: 10.1055/s-0028-1085464
Short Communication

© Georg Thieme Verlag KG Stuttgart · New York

Wilson's Disease: Appreciable Improvement of Sub-cortical White Matter Abnormalities after Copper Chelating Treatment: Five Years Follow-up

A. Larnaout 1 , N. Ammar 1 , Z. Mourad 1 , S. Naji 1 , F. Hentati 1
  • 1Department of Neurology, Institut National de Neurologie, La Rabta Tunis, Tunis, Tunisia
Further Information

Publication History

received 16.11.2007 revised 03.05.2008

accepted 07.07.2008

Publication Date:
07 November 2008 (online)

Abstract

Severe sub-cortical white matter abnormalities are unusual features in Wilson's disease and are reported to be poorly or not responsive to copper chelating therapy or to be worsened by it. We report on a 12-year-old boy with Wilson's disease and extensive sub-cortical white matter involvement. After five years of copper chelating therapy, an appreciable improvement of these lesions was obtained. The physiopathology of these unusual cerebral white matter abnormalities is discussed.

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Correspondence

A. Larnaout

Department of Neurology

Institut National de Neurologie

La Rabta Tunis

1007 Tunis

Tunisia

Phone: +216/23/829 820

Fax: +216/71/569 113

Email: abdelmajid.larnaout@rns.tn