Triterpenes from Acanthopanax sessiliflorus Fruits and their Antiplatelet Aggregation Activities

Abstract

One new triterpenoid saponin and two lupane-derived triterpenes were isolated from Acanthopanax sessiliflorus fruits. The structures of the two new compounds were elucidated as 3-O-[(α-L-arabinopyranosyl)-(1 → 2)]-[β-D-glucuronopyranosyl-6-O-methyl ester]-olean-12-ene-28-olic acid (1) and (1R,11α,22α)-1,4-epoxy-11,22-hydroxy-3,4-secolupane-20(30)-ene-3,28-dioic acid (3) on the basis of spectral analysis, including MS, ¹H‐NMR, ¹³C‐NMR, DEPT, HMBC, HMQC and NOESY. The structure of the other new natural product was elucidated as (1R,11α)-1,4-epoxy-11-hydroxy-3,4-secolupane-20(30)-ene-3,28-dioic acid (2). All these compounds showed antiplatelet aggregation activity on ADP-induced platelet aggregation.

Key words

Araliaceae - Acanthopanax sessiliflorus - triterpenes - antiplatelet aggregation

References

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