Three New Vanilloid Derivatives from the Stems of Baccaurea ramiflora

Abstract

Three new (1−3) and four known (4−7) compounds were isolated from the stems of Baccaurea ramiflora. By analysis of 1D, 2D NMR, and MS data, the new compounds were identified as 4′-O-(6-O-vanilloyl)-β-D-glucopyranosyl tachioside D (1), 6′-O-vanilloylpicraquassioside D (2), and 6′-O-vanilloylicariside B₅ (3). Compound 1 exhibited significant DPPH radical-scavenging activity, with an IC₅₀ value of 36.9 µM, while compound 4 revealed weak antioxidant activity against H₂O₂-induced impairment in PC12 cells.

Baccaurea ramiflora - Euphorbiaceae - PC12 cells - antioxidant - DPPH - vanilloid

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