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Diabetes aktuell 2009; 7(1): 19-25
DOI: 10.1055/s-0029-1208370
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© Georg Thieme Verlag Stuttgart · New York

Genetik des Diabetes mellitus – Prädiktive genetische Tests werden kontrovers diskutiert

Genetics of diabetes mellitus – Predictive genetic tests are controversally discussedPeter E.H. Schwarz1 , Stefan R. Bornstein1
  • 1Medizinische Klinik III, Universitätsklinikum Carl Gustav Carus der Technischen Universität Dresden Ärztlicher Direktor: Prof. S. Bornstein
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Publication Date:
18 February 2009 (online)

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Das Risiko, dass Kinder von Typ–2–Diabetikern selbst an Typ–2–Diabetes (T2DM) erkranken liegt zwischen 25 und 50? %. Neben den bekannten Risikofaktoren, wie Übergewicht und Bewegungsmangel, ist wahrscheinlich eine genetische Prädisposition Auslöser des T2DM. Forschungsergebnisse der letzten Jahre zeigen, dass genetische Faktoren in der Pathogenese des T2DM eine entscheidende Rolle spielen. Eine prädiktive genetische Testung auf ein Diabetesrisiko kann schon heute eingesetzt werden, um individualisierte präventive oder therapeutische Interventionen zu gestalten. Die Kenntnis über ein vererbtes Erkrankungsrisiko kann z.?B. genutzt werden, um bei Betroffenen eine stärkere Motivation zur Lebensstiländerung zu erreichen. Allerdings besteht noch ein erheblicher Forschungsbedarf, um die Evidenz der prädiktiven genetischen Tests nachzuweisen.

The risk that children of type 2 diabetics will also suffer from type 2 diabetes (T2DM) is between 25 and 50? %. In addition to the known risk factors such as overweight and insufficient activity, a genetic predisposition is probably also responsible for triggering T2DM. Research conducted during the past few years points to genetic factors as decisive contributors to T2DM pathogenesis. Predictive genetic testing for risk of diabetes is already possible for the purpose of initiating individual preventive or therapeutic action. For example, if an inherited risk of diabetes is known, it would be possible to encourage an individual to change his lifestyle. However, considerably more research is imperative to prove the evidence of the predictive genetic tests.

Key words

Type 2 diabetes - genetic predisposition– genetic factors - predictive genetic testing - inherited disease risk

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Korrespondenz

Prof. Dr. med. habil. Peter E. H. Schwarz

Medizinische Klinik III Universitätsklinikum Carl Gustav Carus der Technischen Universität Dresden

Email: peter.schwarz@uniklinikum-dresden.de

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