Acute Antihypertensive Therapy in Pregnancy-Induced Hypertension: Is Nicardipine the Answer?

Rakesh B Vadhera; Luis D Pacheco; Gary D.V Hankins

doi:10.1055/s-0029-1214251

American Journal of Perinatology, Table of Contents

Am J Perinatol 2009; 26(7): 495-499
DOI: 10.1055/s-0029-1214251

Acute Antihypertensive Therapy in Pregnancy-Induced Hypertension: Is Nicardipine the Answer?

Rakesh B. Vadhera¹ , Luis D. Pacheco¹ ^, ² ^, ³ , Gary D.V Hankins²

¹Department of Anesthesiology, The University of Texas Medical Branch at Galveston, Galveston, Texas
²Department of Obstetrics and Gynecology, The University of Texas Medical Branch at Galveston, Galveston, Texas
³Division of Maternal Fetal Medicine, Division of Surgical Critical Care, The University of Texas Medical Branch at Galveston, Galveston, Texas

Abstract

ABSTRACT

Hypertensive disorders in pregnancy constitute one of the most frequent medical complications during gestation. Unfortunately, maternal and perinatal mortality remains significant worldwide in this population. Not infrequently, patients with severe preeclampsia will need parenteral agents to achieve rapid blood pressure control to avoid end-organ damage. During the last decades, new antihypertensive medications have become available for management of hypertensive crisis. One of these agents is the calcium channel blocker nicardipine. Nicardipine has been used extensively in different clinical settings including neurosurgery, cardiothoracic surgery, transplant medicine, and internal medicine patients. Minimal data exist in the literature regarding the use of this medicine during pregnancy. The purpose of this article is to review the pharmacological properties of nicardipine, the available literature regarding its use during pregnancy, and potential interactions with other medicines used commonly in preeclampsia, as well as potential side effects directly affecting the peripartum period.

KEYWORDS

Preeclampsia - hypertension - nicardipine

Full Text

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Rakesh B VadheraM.B.B.S. F.R.C.A. F.F.A.R.C.S.I.

Department of Anesthesiology, The University of Texas Medical Branch at Galveston

301 University Boulevard, Galveston, TX 77555-0591

Email: rbvadher@utmb.edu