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Synthesis 2010(3): 453-464  
DOI: 10.1055/s-0029-1217116
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Efficient One-Pot Synthesis of Spirooxindole Derivatives by Ethylenediamine Diacetate Catalyzed Reactions in Water

Galla Sri Hari, Yong Rok Lee*
School of Chemical Engineering and Technology, Yeungnam University, Gyeongsan 712-749, South Korea
Fax: +82(53)8104631; e-Mail: yrlee@yu.ac.kr;
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Publication History

Received 2 September 2009
Publication Date:
13 November 2009 (online)

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Abstract

A simple and efficient one-pot synthetic approach was used for the preparation of biologically interesting spirooxindole derivatives by means of three-component reactions of isatins, malononitrile, and 1,3-dicarbonyl compounds catalyzed by ethylenediamine diacetate (EDDA) in an aqueous medium. This method is of great value because of its environmentally benign character, high yield, and easy handling.

Key words

spiro compounds - indoles - catalysis - Brønsted acids - Brønsted bases - water

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