Interventionelle Behandlung der malignen Hypertonie – Pathophysiologie und klinische Daten

Abstract

Overactivity of the sympathetic nervous system has been identified as one of the main contributors to the complex pathophysiology of resistant hypertension and the development of comorbidities. There is evidence that catheter-based renal sympathetic denervation can lower central sympathetic outflow, reduce whole-body norepinephrine spillover and is associated with substantial and sustained reduction in blood pressure. Interventional sympathetic renal denervation is easy achievable, safe and effective and might be helpful in the management of patients with therapy resistant hypertension. The results of the ongoing randomised controlled Symplicity HTN-2 trial are required to definitively determine the role of this new method.

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