Zusammenfassung
Hintergrund: Es ist bekannt, dass viele Patienten mit schizophrenen Erkrankungen Non-Adhärenz
bzgl. der regelmäßigen Einnahme antipsychotischer Medikamente zeigen. Zum anderen
weisen viele Studien auf kognitive Defizite der Betroffenen hin. In dieser Übersichtsarbeit
sollen die Ergebnisse von Studien, die den Zusammenhang von Non-Adhärenz und kognitiver
Leistungsfähigkeit untersucht haben, gegenübergestellt werden. Methode: Mittels einer systematischen Literaturrecherche wurde der Zusammenhang kognitiver
Leistungsparameter mit dem Ausmaß der Adhärenz schizophrener Patienten untersucht.
Ergebnisse: Es konnten 18 Studien ermittelt werden, in welchen der Zusammenhang zwischen kognitiver
Leistungsfähigkeit und adhärentem Verhalten untersucht wurde. Ein Großteil der Studien
belegt, dass Patienten mit stärkeren kognitiven Beeinträchtigungen weniger adhärentes
Verhalten zeigen. Die möglichen kausalen Mechanismen dieses Zusammenhangs werden diskutiert.
Abstract
Background: It is known that many patients with schizophrenia show non-adherence with regard
to antipsychotic medication. Furthermore, many studies indicate cognitive deficits
in schizophrenic patients. In this review, we compare the results of studies examining
the relationship of non-adherence and cognitive performance. Method: Based on a systematic literature review, the impact of cognitive performance on the
adherence behaviour of patients with schizophrenia was examined. Results: We found 18 studies analysing the impact of cognitive performance on adherence behaviour.
Most studies indicated that patients with stronger cognitive impairments show lower
adherence behaviour. Possible causal mechanisms are discussed.
Schlüsselwörter
Adhärenz - Compliance - Schizophrenie - Neurokognition - kognitive Beeinträchtigungen
Keywords
adherence - compliance - schizophrenia - neurocognition - cognitive impairment
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Alexa Spiekermann
Abteilung für Forschung, Qualitätssicherung und DokumentationKlinik für Psychiatrie
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