Whole-Body MR Imaging in a Multimodality World: Current Applications, Limitations, and Future Potential for Comprehensive Musculoskeletal Imaging

ABSTRACT

Whole-body imaging offers the promise of global disease assessment. This article reviews clinical status, and technical limitations and future prospects of this exciting technology. In particular, it describes technical aspects of magnetic resonance (MR) angiography, MR lymphography, and, in particular, total-body MR imaging.

WBMRI - MR angiography - MR lymphography

REFERENCES

• 1 Siegel M J. Magnetic resonance imaging of musculoskeletal soft tissue masses.  Radiol Clin North Am. 2001;  39(4) 701-720
• 2 Schöder H, Larson S M. Positron emission tomography for prostate, bladder, and renal cancer.  Semin Nucl Med. 2004;  34(4) 274-292
• 3 Nazarian L N. The top 10 reasons musculoskeletal sonography is an important complementary or alternative technique to MRI.  AJR Am J Roentgenol. 2008;  190(6) 1621-1626
• 4 Smith N J, Shihab O, Arnaout A, Swift R I, Brown G. MRI for detection of extramural vascular invasion in rectal cancer.  AJR Am J Roentgenol. 2008;  191(5) 1517-1522
• 5 Abrahm J L, Banffy M B, Harris M B. Spinal cord compression in patients with advanced metastatic cancer: “all I care about is walking and living my life”.  JAMA. 2008;  299(8) 937-946
• 6 Taylor F G, Swift R I, Blomqvist L, Brown G. A systematic approach to the interpretation of preoperative staging MRI for rectal cancer.  AJR Am J Roentgenol. 2008;  191(6) 1827-1835
• 7 Lall C G, Howard T J, Skandarajah A, DeWitt J M, Aisen A M, Sandrasegaran K. New concepts in staging and treatment of locally advanced pancreatic head cancer.  AJR Am J Roentgenol. 2007;  189(5) 1044-1050
• 8 Schöder H, Herrmann K, Gönen M et al.. 2-[18F]fluoro-2-deoxyglucose positron emission tomography for the detection of disease in patients with prostate-specific antigen relapse after radical prostatectomy.  Clin Cancer Res. 2005;  11(13) 4761-4769
• 9 Rinnab L, Mottaghy F M, Blumstein N M et al.. Evaluation of [11C]-choline positron-emission/computed tomography in patients with increasing prostate-specific antigen levels after primary treatment for prostate cancer.  BJU Int. 2007;  100(4) 786-793
• 10 Higton A M, Monach J, Congleton J. Investigation and management of lung cancer in older adults.  Lung Cancer. 2009;  , December 15 (Epub ahead of print)
• 11 Meaney J F. Magnetic resonance angiography of the peripheral arteries: current status.  Eur Radiol. 2003;  13(4) 836-852
• 12 Kalender W A, Seissler W, Klotz E, Vock P. Spiral volumetric CT with single-breath-hold technique, continuous transport, and continuous scanner rotation.  Radiology. 1990;  176(1) 181-183
• 13 Kapoor V, McCook B M, Torok F S. An introduction to PET-CT imaging.  Radiographics. 2004;  24(2) 523-543
• 14 Kapoor V, Fukui M B, McCook B M. Role of 18FFDG PET/CT in the treatment of head and neck cancers: principles, technique, normal distribution, and initial staging.  AJR Am J Roentgenol. 2005;  184(2) 579-587
• 15 Feng S, Ji J. Channel reduction in massive array parallel MRI.  Conf Proc IEEE Eng Med Biol Soc. 2009;  1 4045-4048
• 16 Wright S M, McDougall M P, Feng K, Hollingsworth N A, Bosshard J C, Chang C W. Highly parallel transmit/receive systems for dynamic MRI.  Conf Proc IEEE Eng Med Biol Soc. 2009;  1 4053-4056
• 17 Kruger D G, Riederer S J, Grimm R C, Rossman P J. Continuously moving table data acquisition method for long FOV contrast-enhanced MRA and whole-body MRI.  Magn Reson Med. 2002;  47(2) 224-231
• 18 Kramer H, Zenge M, Schmitt P, Glaser C, Reiser M F, Herrmann K A. Peripheral magnetic resonance angiography (MRA) with continuous table movement at 3.0 T: initial experience compared with step-by-step MRA.  Invest Radiol. 2008;  43(9) 627-634
• 19 Eustace S, Tello R, DeCarvalho V et al.. A comparison of whole-body turboSTIR MR imaging and planar 99mTc-methylene diphosphonate scintigraphy in the examination of patients with suspected skeletal metastases.  AJR Am J Roentgenol. 1997;  169(6) 1655-1661
• 20 Puls R, Kuhn J P, Ewert R, Hosten N. Whole-body magnetic resonance imaging for staging of lung cancer.  Front Radiat Ther Oncol. 2010;  42 46-54
• 21 Lütje S, de Rooy J W, Croockewit S, Koedam E, Oyen W J, Raymakers R A. Role of radiography, MRI and FDG-PET/CT in diagnosing, staging and therapeutical evaluation of patients with multiple myeloma.  Ann Hematol. 2009;  88(12) 1161-1168
• 22 Bäuerle T, Hillengass J, Fechtner K et al.. Multiple myeloma and monoclonal gammopathy of undetermined significance: importance of whole-body versus spinal MR imaging.  Radiology. 2009;  252(2) 477-485
• 23 Daldrup-Link H E, Franzius C, Link T M et al.. Whole-body MR imaging for detection of bone metastases in children and young adults: comparison with skeletal scintigraphy and FDG PET.  AJR Am J Roentgenol. 2001;  177(1) 229-236
• 24 Gutzeit A, Doert A, Froehlich J M et al.. Comparison of diffusion-weighted whole body MRI and skeletal scintigraphy for the detection of bone metastases in patients with prostate or breast carcinoma.  Skeletal Radiol. 2009 Sep 8; 
• 25 Rubens R D. Bone metastases—the clinical problem.  Eur J Cancer. 1998;  34(2) 210-213
• 26 Lecouvet F E, Malghem J, Michaux L et al.. Skeletal survey in advanced multiple myeloma: radiographic versus MR imaging survey.  Br J Haematol. 1999;  106(1) 35-39
• 27 Imamura F, Kuriyama K, Seto T et al.. Detection of bone marrow metastases of small cell lung cancer with magnetic resonance imaging: early diagnosis before destruction of osseous structure and implications for staging.  Lung Cancer. 2000;  27(3) 189-197
• 28 Steinborn M M, Heuck A F, Tiling R, Bruegel M, Gauger L, Reiser M F. Whole-body bone marrow MRI in patients with metastatic disease to the skeletal system.  J Comput Assist Tomogr. 1999;  23(1) 123-129
• 29 Lauenstein T C, Freudenberg L S, Goehde S C et al.. Whole-body MRI using a rolling table platform for the detection of bone metastases.  Eur Radiol. 2002;  12(8) 2091-2099
• 30 Antoch G, Vogt F M, Freudenberg L S et al.. Whole-body dual-modality PET/CT and whole-body MRI for tumor staging in oncology.  JAMA. 2003;  290(24) 3199-3206
• 31 Ghanem N, Lohrmann C, Engelhardt M et al.. Whole-body MRI in the detection of bone marrow infiltration in patients with plasma cell neoplasms in comparison to the radiological skeletal survey.  Eur Radiol. 2006;  16(5) 1005-1014
• 32 Walker R, Kessar P, Blanchard R et al.. Turbo STIR magnetic resonance imaging as a whole-body screening tool for metastases in patients with breast carcinoma: preliminary clinical experience.  J Magn Reson Imaging. 2000;  11(4) 343-350
• 33 Antoch G, Saoudi N, Kuehl H et al.. Accuracy of whole-body dual-modality fluorine-18-2-fluoro-2-deoxy-D-glucose positron emission tomography and computed tomography (FDG-PET/CT) for tumor staging in solid tumors: comparison with CT and PET.  J Clin Oncol. 2004;  22(21) 4357-4368
• 34 Biederer J, Hintze C, Fabel M. MRI of pulmonary nodules: technique and diagnostic value.  Cancer Imaging. 2008;  8 125-130
• 35 Boss A, Schaefer S, Martirosian P, Claussen C D, Schick F, Schaefer J F. Magnetic resonance imaging of lung tissue: influence of body positioning, breathing and oxygen inhalation on signal decay using multi-echo gradient-echo sequences.  Invest Radiol. 2008;  43(6) 433-438
• 36 Fink C, Puderbach M, Biederer J et al.. Lung MRI at 1.5 and 3 Tesla: observer preference study and lesion contrast using five different pulse sequences.  Invest Radiol. 2007;  42(6) 377-383
• 37 Jansen J F, Stambuk H E, Koutcher J A, Shukla-Dave A. Non-Gaussian analysis of diffusion-weighted MR imaging in head and neck squamous cell carcinoma: a feasibility study.  AJNR Am J Neuroradiol. 2009; 
• 38 Kim C K, Park B K, Kim B. High-b-value diffusion-weighted imaging at 3 T to detect prostate cancer: comparisons between b values of 1,000 and 2,000 s/mm2.  AJR Am J Roentgenol. 2010;  194(1) W33–7
• 39 Eiber M, Beer A J, Holzapfel K et al.. Preliminary results for characterization of pelvic lymph nodes in patients with prostate cancer by diffusion-weighted MR-imaging.  Invest Radiol. 2010;  45(1) 15-23
• 40 Liu Y, Bai R, Sun H, Liu H, Wang D. Diffusion-weighted magnetic resonance imaging of uterine cervical cancer.  J Comput Assist Tomogr. 2009;  33(6) 858-862
• 41 Nakayama J, Miyasaka K, Omatsu T et al.. Metastases in mediastinal and hilar lymph nodes in patients with non-small cell lung cancer: quantitative assessment with diffusion-weighted magnetic resonance imaging and apparent diffusion coefficient.  J Comput Assist Tomogr. 2010;  34(1) 1-8
• 42 Barajas Jr R F, Rubenstein J L, Chang J S, Hwang J, Cha S. Diffusion-weighted MR imaging derived apparent diffusion coefficient is predictive of clinical outcome in primary central nervous system lymphoma.  AJNR Am J Neuroradiol. 2009;  , October 8 (Epub ahead of print)
• 43 Kim S H, Cha E S, Kim H S et al.. Diffusion-weighted imaging of breast cancer: correlation of the apparent diffusion coefficient value with prognostic factors.  J Magn Reson Imaging. 2009;  30(3) 615-620
• 44 Hamm B. Iron-oxide-enhanced MR lymphography: just a new toy or a breakthrough?.  Eur Radiol. 2002;  12(5) 957-958
• 45 Harisinghani M G, Barentsz J O, Hahn P F et al.. MR lymphangiography for detection of minimal nodal disease in patients with prostate cancer.  Acad Radiol. 2002;  9(suppl 2) S312-S313
• 46 Golder W A. Lymph node diagnosis in oncologic imaging: a dilemma still waiting to be solved.  Onkologie. 2004;  27(2) 194-199
• 47 Prince M R. Gadolinium-enhanced MR aortography.  Radiology. 1994;  191(1) 155-164
• 48 Prince M R, Narasimham D L, Stanley J C et al.. Breath-hold gadolinium-enhanced MR angiography of the abdominal aorta and its major branches.  Radiology. 1995;  197(3) 785-792
• 49 Meaney J F, Ridgway J P, Chakraverty S et al.. Stepping-table gadolinium-enhanced digital subtraction MR angiography of the aorta and lower extremity arteries: preliminary experience.  Radiology. 1999;  211(1) 59-67
• 50 Ruehm S G, Goyen M, Barkhausen J et al.. Rapid magnetic resonance angiography for detection of atherosclerosis.  Lancet. 2001;  357(9262) 1086-1091
• 51 Zhang H L, Ho B Y, Chao M et al.. Decreased venous contamination on 3D gadolinium-enhanced bolus chase peripheral MR angiography using thigh compression.  AJR Am J Roentgenol. 2004;  183(4) 1041-1047
• 52 Kramer H, Quick H H, Tombach B, Schoenberg S O, Barkhausen J. Whole-body MRA.  Eur Radiol. 2008;  18(9) 1925-1936
• 53 Weckbach S, Schoenberg S O. Whole body MR imaging in diabetes.  Eur J Radiol. 2009;  70(3) 424-430
• 54 Waugh S A, Ramkumar P G, Gandy S J et al.. Optimization of the contrast dose and injection rates in whole-body MR angiography at 3.0T.  J Magn Reson Imaging. 2009;  30(5) 1059-1067
• 55 Kramer H, Morana G. Whole-body magnetic resonance angiography with blood-pool agents.  Eur Radiol. 2007;  17(suppl 2) B24-B29
• 56 Klessen C, Hein P A, Huppertz A et al.. First-pass whole-body magnetic resonance angiography (MRA) using the blood-pool contrast medium gadofosveset trisodium: comparison to gadopentetate dimeglumine.  Invest Radiol. 2007;  42(9) 659-664
• 57 Miller T T. MR imaging of the knee.  Sports Med Arthrosc. 2009;  17(1) 56-67
• 58 Murray P J, Shaffer B S. Clinical update: MR imaging of the shoulder.  Sports Med Arthrosc. 2009;  17(1) 40-48
• 59 Rennie W J, Dhillon S S, Conner-Spady B, Maksymowych W P, Lambert R G. Magnetic resonance imaging assessment of spinal inflammation in ankylosing spondylitis: standard clinical protocols may omit inflammatory lesions in thoracic vertebrae.  Arthritis Rheum. 2009;  61(9) 1187-1193
• 60 Weber U, Hodler J, Kubik R A et al.. Sensitivity and specificity of spinal inflammatory lesions assessed by whole-body magnetic resonance imaging in patients with ankylosing spondylitis or recent-onset inflammatory back pain.  Arthritis Rheum. 2009;  61(7) 900-908
• 61 Weber U, Maksymowych W P, Jurik A G et al.. Validation of whole-body against conventional magnetic resonance imaging for scoring acute inflammatory lesions in the sacroiliac joints of patients with spondylarthritis.  Arthritis Rheum. 2009;  61(7) 893-899
• 62 Mager A K, Althoff C E, Sieper J, Hamm B, Hermann K G. Role of whole-body magnetic resonance imaging in diagnosing early spondyloarthritis.  Eur J Radiol. 2009;  71(2) 182-188
• 63 Maksymowych W P. MRI in ankylosing spondylitis.  Curr Opin Rheumatol. 2009;  21(4) 313-317
• 64 Althoff C E, Appel H, Rudwaleit M et al.. Whole-body MRI as a new screening tool for detecting axial and peripheral manifestations of spondyloarthritis.  Ann Rheum Dis. 2007;  66(7) 983-985
• 65 Baraliakos X, Landewé R, Hermann K G et al.. Inflammation in ankylosing spondylitis: a systematic description of the extent and frequency of acute spinal changes using magnetic resonance imaging.  Ann Rheum Dis. 2005;  64(5) 730-734