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Semin Respir Crit Care Med 2010; 31(3): 334-342
DOI: 10.1055/s-0030-1254073
© Thieme Medical PublishersDOI: 10.1055/s-0030-1254073
Oxygen Therapy in Advanced COPD: In Whom Does it Work?
Further Information
Publication History
Publication Date:
21 May 2010 (online)
ABSTRACT
Supplemental oxygen therapy is commonly used in patients with advanced chronic obstructive pulmonary disease (COPD) and severe hypoxemia at rest. Use of oxygen in these patients is justified by studies showing a mortality benefit.
However, the use of oxygen in other patients with advanced COPD has not clearly been established. Long-term studies assessing not only mortality but also other outcomes that are important to patients and physicians such as dyspnea, health status, and exercise capacity are lacking. This article reviews the available studies of the use of supplemental oxygen in patients with less severe hypoxemia at rest during the day, hypoxemia occurring only at night, and hypoxemia occurring only with exercise. With the knowledge that studies in patients with advanced COPD and less severe hypoxemia are limited, recommendations are provided on oxygen use in these groups of patients.
KEYWORDS
Oxygen therapy - mortality - COPD - dyspnea - health-related quality of life
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Barry MakeM.D.
National Jewish Health, 1400 Jackson St.
K729, Denver, CO 80206
Email: makeb@njhealth.org