Renale Denervierung bei therapierefraktärer Hypertonie

Abstract

Overactivity of the sympathetic nervous system has been identified as an important contributor to resistant hypertension. Renal artery radiofrequency ablation is a new therapeutic approach for these patients. As shown in the Simplicity HTN-1 and -2 trials, there is evidence that catheter-based renal denervation has a substantial impact on central sympathetic outflow by reducing the renal norephedrine spillover and is associated with a sustained reduction in blood pressure. Importantly, these studies demonstrated peri- and postinterventional safety and may thus represent a promising option in management of patients with therapy-resistant hypertension as well as concomitant comorbidities.

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