RSS-Feed abonnieren
DOI: 10.1055/s-0030-1257108
© Georg Thieme Verlag KG Stuttgart · New York
Aktueller Status der katheterinterventionellen Behandlung der koronaren Herzerkrankung
Publikationsverlauf
Publikationsdatum:
02. Februar 2012 (online)

Abstract
Here, we describe current interventional techniques for the treatment of coronary artery disease focusing on recent drug-eluting stent (DES) developments. The introduction of DES in the beginning of the century revolutionized interventional cardiology by a dramatic improvement of in-stent restenosis (ISR) rates. However, in higher risk coronary lesions, clinical outcome is still severely crisscrossed by elevated ISR and often fatal stent thrombosis. Therefore, anew paradigm shifts are on the horizon with promising novel developments, e. g. biodegradable stents.
Literatur
- 1
Mueller R L, Sanborn T A.
The history of interventional cardiology: cardiac
catheterization, angioplasty, and related interventions.
Am Heart J.
1995;
129
146-172
DOI: 10.1016/0002-8703(95)90055-1
Reference Ris Wihthout Link
- 2
Schlumpf M.
30 Jahre Ballonkatheter: Andreas Grüntzig, ein Pionier
in Zürich.
Schweizerische Ärztezeitung.
2004;
85
3460
Reference Ris Wihthout Link
- 3
Simsek C, Serruys P W.
Developments in coronary artery stenting: primum non
nocere.
Panminerva Med.
2011;
53
19-30
Reference Ris Wihthout Link
- 4
Fischman D L, Leon M B, Baim D S et al., for the Stent Restenosis Study
Investigators.
A Randomized Comparison of Coronary-Stent Placement and
Balloon Angioplasty in the Treatment of Coronary Artery Disease.
N Engl J Med.
1994;
331
496-501
Reference Ris Wihthout Link
- 5
Cutlip D E, Chauhan M S, Baim D S et al.
Clinical restenosis after coronary stenting: perspectives
from multicenter clinical trials.
J Am Coll Cardiol.
2002;
40
2082
Reference Ris Wihthout Link
- 6
Roukoz H, Bavry A A, Sarkees M L et al.
Comprehensive meta-analysis on drug-eluting stents versus
bare-metal stents during extended follow-up.
Am J Med.
2009;
122
581
e1 – e10
Reference Ris Wihthout Link
- 7
Costa M A, Simon D I.
Molecular basis of restenosis and drug-eluting stents.
Circulation.
2005;
111
2257-2273
Reference Ris Wihthout Link
- 8
Morice M C, Serruys P W, Sousa J E et al., RAVEL Study Group.
A randomized comparison of a sirolimus-eluting stent with a
standard stent for coronary revascularization.
N Engl J Med.
2002;
346
1773-1780
Reference Ris Wihthout Link
- 9
Stone G W, Ellis S G, Cox D A et al.
A polymer-based, paclitaxel-eluting stent in patients with
coronary artery disease.
N Engl J Med.
2004;
350
221
Reference Ris Wihthout Link
- 10
Serruys P W et al.
RESOLUTE All Comers Trial. Comparison of zotarolimus-eluting
and everolimus-eluting coronary stents.
N Engl J Med.
2010;
363
136-146
Reference Ris Wihthout Link
- 11
Scheller B, Hehrlein C, Bocksch W et al.
Treatment of coronary in-stent restenosis with a
paclitaxel-coated balloon catheter.
N Engl J Med.
2006;
355
2113
Reference Ris Wihthout Link
- 12
Unverdorben M, Vallbracht C, Cremers B et al.
Paclitaxel-coated balloon catheter versus paclitaxel-coated
stent for the treatment of coronary in-stent restenosis.
Circulation.
2009;
119
2986
Reference Ris Wihthout Link
- 13
Garg S et al.
The twelve-month outcomes of a biolimus eluting stent with a
biodegradable polymer compared with a sirolimus eluting stent with a durable
polymer.
EuroIntervention.
2010;
6
233-239
Reference Ris Wihthout Link
- 14
Grube E, Schofer J, Hauptmann K E et al.
A novel paclitaxel-eluting stent with an ultrathin abluminal
biodegradable polymer 9-month outcomes with the JACTAX HD stent.
JACC Cardiovasc Interv.
2010;
4
431-438
Reference Ris Wihthout Link
- 15
Guagliumi G, Sirbu V, Musumeci G et al.
Strut coverage and vessel wall response to a new-generation
paclitaxel-eluting stent with an ultrathin biodegradable abluminal polymer:
Optical Coherence Tomography Drug-Eluting Stent Investigation (OCTDESI).
Circ Cardiovasc Interv.
2010;
4
367-375
[Epub 2010 Jul 20]
Reference Ris Wihthout Link
- 16
Byrne R A, Kastrati A, Massberg S et al., ISAR-TEST 4 Investigators.
Biodegradable polymer versus permanent polymer drug-eluting
stents and everolimus- versus sirolimus-eluting stents in patients with
coronary artery disease 3-year outcomes from a randomized clinical trial.
J Am Coll Cardiol.
2011;
58
1325-1331
Reference Ris Wihthout Link
- 17
Massberg S, Byrne R A, Kastrati A et al., ISAR-TEST 4 Investigators.
Polymer-free sirolimus- and probucol-eluting versus new
generation zotarolimus-eluting stents in coronary artery disease: the
Intracoronary Stenting and Angiographic Results: (ISAR-TEST 5) trial.
Circulation.
2011;
124
624-632
[Epub 2011 Jul 18]
Reference Ris Wihthout Link
- 18
Virmani R et al.
Localized hypersensitivity and late coronary thrombosis
secondary to a sirolimus-eluting stent: Should we be cautious?.
Circulation.
2004;
109
701-705
Reference Ris Wihthout Link
- 19
Liu H T, Li F, Wang W Y et al.
Rapamycin inhibits re-endothelialization after percutaneous
coronary intervention by impeding the proliferation and migration of
endothelial cells and inducing apoptosis of endothelial progenitor cells.
Tex Heart Inst J.
2010;
37
194-201
Reference Ris Wihthout Link
- 20
Yusuf R Z, Duan Z, Lamendola D E et al.
Paclitaxel resistance: molecular mechanisms and pharmacologic
manipulation.
Curr Cancer Drug Targets.
2003;
3
1-19
Reference Ris Wihthout Link
- 21
Huang S, Houghton P J.
Mechanisms of resistance to rapamycins.
Drug Resist Updat.
2001;
4
378-391
Reference Ris Wihthout Link
- 22
Farb A, John M, Acampado E et al.
Oral Everolimus Inhibits In-Stent Neointimal Growth.
Circulation.
2002;
106
2379-2384
DOI: 10.1161/01.CIR.0000033973.06059.04
Reference Ris Wihthout Link
- 23
Suzuki T, Kopia G, Hayashi S et al.
Stent-Based Delivery of Sirolimus Reduces Neointimal
Formation in a Porcine Coronary Model.
Circulation.
2001;
104
1188-1193
DOI: 10.1161/hc3601.093987
Reference Ris Wihthout Link
- 24
Pfisterer M et al.
Late clinical events after clopidogrel discontinuation may
limit the benefit of drug-eluting stents: an observational study of
drug-eluting versus baremetal stents.
J Am Coll Cardiol.
2006;
48
2584-2591
Reference Ris Wihthout Link
- 25
Lüscher T F, Steffel J, Eberli F R et al.
Drug-Eluting Stent and Coronary Thrombosis: Biological
Mechanisms and Clinical Implications.
Circulation.
2007;
115
1051-1058
Reference Ris Wihthout Link
- 26
Moses J W, Leon M B, Popma J J et al.
Sirolimus-eluting stents versus standard stents in patients
with stenosis in a native coronary artery.
N Engl J Med.
2003;
349
1315-1323
Reference Ris Wihthout Link
- 27
Stone G W, Ellis S G, Cox D A et al.
One-year clinical results with the slow-release,
polymer-based, paclitaxel-eluting TAXUS stent: the TAXUS-IV trial.
Circulation.
2004;
109
1942-1947
Reference Ris Wihthout Link
- 28
Roiron C, Sanchez P, Bouzamondo A et al.
Drug eluting stents: an updated meta-analysis of randomised
controlled trials.
Heart.
2006;
92
6416
Reference Ris Wihthout Link
- 29
Stettler C, Wandel S, Allemann S et al.
Outcomes associated with drug-eluting and bare-metal stents:
a collaborative network meta-analysis.
Lancet.
2007;
370
937
Reference Ris Wihthout Link
- 30
Stone G W, Midei M, Newman W et al. SPIRIT III Investigators.
Randomized comparison of everolimus-eluting and
paclitaxel-eluting stents: two-year clinical follow-up from the Clinical
Evaluation of the Xience V Everolimus Eluting Coronary Stent System in the
Treatment of Patients with de novo Native Coronary Artery Lesions (SPIRIT) III
trial.
Circulation.
2009;
119
680-686
[Epub 2009 Jan 26]
Reference Ris Wihthout Link
- 31
Smits P C, Kedhi E, Royaards K J et al.
2-year follow-up of a randomized controlled trial of
everolimus- and paclitaxel-eluting stents for coronary revascularization in
daily practice. COMPARE (Comparison of the everolimus eluting XIENCE-V stent
with the paclitaxel eluting TAXUS LIBERTÉ stent in all-comers: a
randomized open label trial).
J Am Coll Cardiol.
2011;
58
11-18
[Epub 2011 Apr 21]
Reference Ris Wihthout Link
- 32
Byrne R A, Kastrati A, Massberg S et al., ISAR-TEST 4 Investigators.
Biodegradable polymer versus permanent polymer drug-eluting
stents and everolimus- versus sirolimus-eluting stents in patients with
coronary artery disease: 3-year outcomes from a randomized clinical trial.
J Am Coll Cardiol.
2011;
58
1325-1331
Reference Ris Wihthout Link
- 33
Kim W J, Lee S W, Park S W et al., ESSENCE-DIABETES Study Investigators..
Randomized comparison of everolimus-eluting stent versus
sirolimus-eluting stent implantation for de novo coronary artery disease in
patients with diabetes mellitus (ESSENCE-DIABETES): results from the
ESSENCE-DIABETES trial.
Circulation.
2011;
124
886-892
[Epub 2011 Aug 1]
Reference Ris Wihthout Link
- 34
Raber L, Wohlwend L, Wigger M et al.
Five-Year Clinical and Angiographic Outcomes of a Randomized
Comparison of Sirolimus-Eluting and Paclitaxel-Eluting Stents: Results of the
Sirolimus-Eluting Versus Paclitaxel-Eluting Stents for Coronary
Revascularization LATE Trial.
Circulation.
2011;
123
2819-2828
Reference Ris Wihthout Link
- 35
Garg P et al.
Drug-eluting or bare-metal stenting in patients with diabetes
mellitus: results from the Massachusetts Data Analysis Center Registry.
Circulation.
2008;
118
2277-2285
Reference Ris Wihthout Link
- 36
Liistro F et al.
Long-term effectiveness and safety of sirolimus stent
implantation for coronary in-stent restenosis results of the TRUE (Tuscany
Registry of sirolimus for unselected in-stent restenosis) registry at 4
yrs.
J Am Coll Cardiol.
2010;
55
613-616
Reference Ris Wihthout Link
- 37
Elezi S et al.
Vessel size and outcome after coronary drug-eluting stent
placement: results from a large cohort of patients treated with sirolimus- or
paclitaxel-eluting stents.
J Am Coll Cardiol.
2006;
48
1304-1309
Reference Ris Wihthout Link
- 38
Godino C et al.
Clinical and angiographic follow-up of small vessel lesions
treated with paclitaxel-eluting stents (from the TRUE Registry).
Am J Cardiol.
2008;
102
1002-1008
Reference Ris Wihthout Link
- 39
Pfisterer M et al.
Long-term benefit-risk balance of drug-eluting vs. Bare-metal
stents in daily practice: Does stent diameter matter? Three-year follow-up of
BASKET.
Eur Heart J.
2009;
30
16-24
Reference Ris Wihthout Link
- 40
Sheiban I, Infantino V A, Colombo F et al.
Very long-term results comparing a simple versus a complex
stenting strategy in the treatment of coronary bifurcation lesions.
Catheter Cardiovasc Interv.
2009;
74
313-320
Reference Ris Wihthout Link
- 41
Korn H V, Yu J, Ohlow M A et al.
Interventional therapy of bifurcation lesions: a TIMI
flow-guided concept to treat side branches in bifurcation lesions – a
prospective randomized clinical study (Thueringer bifurcation study, THUEBIS
study as pilot trial).
Circ Cardiovasc Interv.
2009;
2
535-542
[Epub 2009 Nov 10]
Reference Ris Wihthout Link
- 42
Behan M W, Holm N R, Curzen N P et al.
Simple or complex stenting for bifurcation coronary lesions:
a patient-level pooled-analysis of the Nordic Bifurcation Study and the British
Bifurcation Coronary Study.
Circ Cardiovasc Interv.
2011;
4
57-64
[Epub 2011 Jan 4]
Reference Ris Wihthout Link
- 43
Mehran R, Claessen B E, Godino C et al.
; Multinational Chronic Total Occlusion Registry. Long-term
outcome of percutaneous coronary intervention for chronic total
occlusions.
JACC Cardiovasc Interv.
2011;
4
952-961
Reference Ris Wihthout Link
- 44
Ioannis I, Schmidt T, Bonizzoni E et al.
Incidence, Predictors, and Outcome of Thrombosis After
Successful Implantation of Drug-Eluting Stents.
JAMA.
2005;
293
2126-2130
Reference Ris Wihthout Link
- 45
Mauri L et al.
Stent thrombosis in randomized clinical trials of
drug-eluting stents.
N Engl J Med.
2007;
356
1020-1029
Reference Ris Wihthout Link
- 46
Camenzind E, Steg P G, Wijns W.
Stent thrombosis late after implantation of first-generation
drug-eluting stents: a cause for concern.
Circulation.
2007;
115
1440-1455
Reference Ris Wihthout Link
- 47
Holmes jr D R et al.
Thrombosis and drug-eluting stents: an objective
appraisal.
J Am Coll Cardiol.
2007;
50
109-118
Reference Ris Wihthout Link
- 48
Mauri L et al.
Stent thrombosis in randomized clinical trials of
drug-eluting stents.
N Engl J Med.
2007;
356
1020-1029
Reference Ris Wihthout Link
- 49
Brodie B, Pokharel Y, Fleishman N et al.
Very late stent thrombosis after primary percutaneous
coronary intervention with bare-metal and drug-eluting stents for ST-segment
elevation myocardial infarction: a 15-year single-center experience.
JACC Cardiovasc Interv.
2011;
4
30-38
Reference Ris Wihthout Link
- 50
Spaulding C et al.
Sirolimus-eluting versus uncoated stents in acute myocardial
infarction.
N Engl J Med.
2009;
355
1093-1104
Reference Ris Wihthout Link
- 51
Dangas G D, Caixeta A, Mehran R et al., Harmonizing Outcomes With Revascularization and
Stents in Acute Myocardial Infarction (HORIZONS-AMI) Trial
Investigators.
Frequency and predictors of stent thrombosis after
percutaneous coronary intervention in acute myocardial infarction.
Circulation.
2011;
123
1745-1756
[Epub 2011 Apr 11]
Reference Ris Wihthout Link
- 52
Byrne R A, Kastrati A, Massberg S et al., ISAR-TEST 4 Investigators.
Biodegradable polymer versus permanent polymer drug-eluting
stents and everolimus- versus sirolimus-eluting stents in patients with
coronary artery disease 3-year outcomes from a randomized clinical trial.
J Am Coll Cardiol.
2011;
58
1325-1331
Reference Ris Wihthout Link
- 53
van Werkum J W, Heestermans A A, de Korte F I et al.
Long-term clinical outcome after a first angiographically
confirmed coronary stent thrombosis: an analysis of 431 cases.
Circulation.
2009;
119
828-834
[Epub 2009 Feb 2]
Reference Ris Wihthout Link
- 54
Lagerqvist B, Carlsson J, Fröbert O et al. Swedish Coronary Angiography and Angioplasty
Registry Study Group.
Stent thrombosis in Sweden: a report from the Swedish
Coronary Angiography and Angioplasty Registry.
Circ Cardiovasc Interv.
2009;
2
401-408
[Epub 2009 Sep 8]
Reference Ris Wihthout Link
- 55
Brar S S et al.
Use of drug-eluting stents in acute myocardial infarction: a
systematic review and meta-analysis.
J Am Coll Cardiol.
2009;
53
1677-1689
Reference Ris Wihthout Link
- 56
Mauri L et al.
Drug-eluting or bare-metal stents for acute myocardial
infarction.
N Engl J Med.
2008;
359
1330-1342
Reference Ris Wihthout Link
- 57
Lee M S et al.
Comparison by meta-analysis of drug-eluting stents and bare
metal stents for saphenous vein graft intervention.
Am J Cardiol.
2010;
105
1076-1082
Reference Ris Wihthout Link
- 58
Sheiban I, Omedé P, Biondi-Zoccai G et al.
Update on dedicated bifurcation stents.
J Interv Cardiol.
2009;
22
150-155
Reference Ris Wihthout Link
- 59
Scheller B et al.
Positionspapier der DGK 2011: Medikamente freisetzende
Koronarstents und mit Medikamenten beschichtete Ballonkatheter.
Der Kardiologe.
2011;
DOI: 10.1007/s12181-011-0375-6
Reference Ris Wihthout Link
- 60
Serruys P W, Onuma Y, Dudek D et al.
Evaluation of the second generation of a bioresorbable
everolimus-eluting vascular scaffold for the treatment of de novo coronary
artery stenosis: 12-month clinical and imaging outcomes.
J Am Coll Cardiol.
2011;
58
1578-1588
Reference Ris Wihthout Link
- 61
Costa jr J R, Abizaid A, Costa R et al.
1-year results of the hydroxyapatite polymer-free
sirolimus-eluting stent for the treatment of single de novo coronary lesions:
the VESTASYNC I trial.
JACC Cardiovasc Interv.
2009;
2
422-427
Reference Ris Wihthout Link
- 62
Tamburino C, La Manna A, Di Salvo M E et al.
First-in-man 1-year clinical outcomes of the Catania Coronary
Stent System with Nanothin Polyzene-F in de novo native coronary artery
lesions: the ATLANTA (Assessment of The LAtest Non-Thrombogenic Angioplasty
stent) trial.
JACC Cardiovasc Interv.
2009;
2
197-204
Reference Ris Wihthout Link
- 63
Lee C W, Park D W, Seung K B et al.
Comparison of dual drug-eluting Cilotax stent and
paclitaxel-eluting Taxus Liberte stent in native coronary artery lesions.
Am J Cardiol.
2011;
107
990-994
[Epub 2011 Feb 4]
Reference Ris Wihthout Link
- 64
Verheye S, Agostoni P, Dubois C L et al.
9-Month Clinical, Angiographic, and Intravascular Ultrasound
Results of a Prospective Evaluation of the Axxess Self-Expanding Biolimus
A9-Eluting Stent in Coronary Bifurcation Lesions: The DIVERGE (Drug-Eluting
Stent Intervention for Treating Side Branches Effectively) Study.
J Am Coll Cardiol.
2009;
53
1031-1039
Reference Ris Wihthout Link
- 65
Amoroso G, van Geuns R J, Spaulding C et al.
Assessment of the safety and performance of the STENTYS
self-expanding coronary stent in acute myocardial infarction: results from the
APPOSITION I study.
EuroIntervention.
2011;
7
428-436
DOI: 10.4244/EIJV7I4A71
Reference Ris Wihthout Link
Priv.-Doz. Dr. med. Felix Vogt
Medizinische Klinik I,
Kardiologie
Universitätsklinik Aachen
Pauwelsstraße 30
52074 Aachen
eMail: fvogt@ukaachen.de