Ligand-Free Copper-Catalyzed
Arylation of Olefins by the Mizoroki-Heck Reaction

Yong Peng; Jiuxi Chen; Jinchang Ding; Miaochang Liu; Wenxia Gao; Huayue Wu

doi:10.1055/s-0030-1258338

PAPER

Ligand-Free Copper-Catalyzed Arylation of Olefins by the Mizoroki-Heck Reaction

Yong Peng^a, Jiuxi Chen*^a, Jinchang Ding^a,b, Miaochang Liu^a, Wenxia Gao^a, Huayue Wu*^a
^a College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325035, P. R. of China
Fax: +86(577)88368280; e-Mail: jiuxichen@gmail.com; e-Mail: huayuewu@wzu.edu.cn ;
^b Wenzhou Vocational and Technical College, Wenzhou 325035, P. R. of China

Abstract

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Abstract

A novel ligand-free copper-catalyzed Mizoroki-Heck cross-coupling reaction of various aryl iodides with olefins has been developed. Both the solvent and the base were found to have a fundamental influence on the efficiency of the transformation in the presence of 10 mol% Cu₂O, with DMF and tetramethylammonium bromide (TMAB) being the optimal solvent and base, respectively. As a result, a set of the corresponding E-internal olefins were obtained selectively in moderate to good yields.

Key words

ligand-free - copper-catalyzed - Mizoroki-Heck reaction - cross-coupling - E-internal olefins

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References

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