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Synthesis 2011(7): 1071-1078  
DOI: 10.1055/s-0030-1258462
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

The Use of Magnesium Nitride for the Synthesis of Enantiomerically Pure 1,4-Dihydropyridines via the Hantzsch Reaction

Sha Longa, Mauro Panunzio*a, Alessandra Petrolia, Wenling Qinb, Zhining Xia*b
a ISOF-CNR, Dipartimento di Chimica ‘G. Ciamician’, Via Selmi 2, 40126 Bologna, Italy
Fax: +39(051)2099456; e-Mail: mauro.panunzio@unibo.it;
b Department of Chemistry and Chemical Engineering, Chongqing University, Chongqing, 400044, P. R. of China
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Publication History

Received 3 January 2011
Publication Date:
08 March 2011 (online)

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Abstract

Enantiomerically pure 1,4-dihydropyridines are prepared taking advantage of magnesium nitride as a useful and convenient source of ‘solid ammonia’. The products possess various substituents at carbons 3, 4 and 5 of the dihydropyridine moiety.

Key words

1,4-dihydropyridines - magnesium nitride - multicomponent reaction - Hantzsch esters - one-pot condensation

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