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Synfacts 2011(7): 0741-0741
DOI: 10.1055/s-0030-1260661
DOI: 10.1055/s-0030-1260661
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Ir-Catalyzed Enantioselective Vinylogous Reformatsky-Type Aldol Reaction
A. Hassan, J. R. Zbieg, M. J. Krische*
University of Texas at Austin, USA
Further Information
Publication History
Publication Date:
17 June 2011 (online)
Significance
This paper reports the first example of catalytic enantioselective vinylogous Reformatsky-type aldol addition reaction using the condition of C-C bond-forming transfer hydrogenation. The linear addition product can be formed from both alcohol and aldehyde oxidation level with equally good to excellent yields, enantio- and regioselectivities.