Dtsch Med Wochenschr 2010; 135(47): 2366-2369
DOI: 10.1055/s-0030-1269401
Aktuelle Diagnostik & Therapie | Review article
Intensivmedizin, Neurologie
© Georg Thieme Verlag KG Stuttgart · New York

Antagonisierung der oralen Antikoagulation bei intrakraniellen Blutungen

Reversal of oral anticoagulation in intracranial hemorrhageJ. Bösel1 , T. Steiner1
  • 1Neurologische Klinik und Poliklinik, Universitätsklinikum Heidelberg
Further Information

Publication History

eingereicht: 14.6.2010

akzeptiert: 26.10.2010

Publication Date:
16 November 2010 (online)

Literatur

  • 1 Aguilar M I, Hart R G, Kase C S. et al . Treatment of warfarin-associated intracerebral hemorrhage: literature review and expert opinion.  Mayo Clin Proc. 2007;  82 82-92
  • 2 Ansell J, Hirsh J, Dalen J. et al . Managing oral anticoagulant therapy.  Chest. 2001;  119 22S-38S
  • 3 Broderick J, Connolly S, Feldmann E. et al . Guidelines for the management of spontaneous intracerebral hemorrhage in adults: 2007 update: a guideline from the American Heart Association/American Stroke Association Stroke Council, High Blood Pressure Research Council, and the Quality of Care and Outcomes in Research Interdisciplinary Working Group.  Stroke. 2007;  38 2001-2023
  • 4 Davis S M, Broderick J, Hennerici M. et al . Hematoma growth is a determinant of mortality and poor outcome after intracerebral hemorrhage.  Neurology. 2006;  66 1175-1181
  • 5 Eckman M H, Rosand J, Knudsen K A, Singer D E, Greenberg S M. Can patients be anticoagulated after intracerebral hemorrhage? A decision analysis.  Stroke. 2003;  34 1710-1716
  • 6 Flaherty M L, Kissela B, Woo D. et al . The increasing incidence of anticoagulant-associated intracerebral hemorrhage.  Neurology. 2007;  68 116-121
  • 7 Flibotte J J, Hagan N, O’Donnell J, Greenberg S M, Rosand J. Warfarin, hematoma expansion, and outcome of intracerebral hemorrhage.  Neurology. 2004;  63 1059-1064
  • 8 Franke C L, de Jonge J, van Swieten J C, Op de Coul A A, van Gijn J. Intracerebral hematomas during anticoagulant treatment.  Stroke. 1990;  21 726-730
  • 9 Gilstad C W. Anaphylactic transfusion reactions.  Curr Opin Hematol. 2003;  10 419-423
  • 10 Hanley J P. Warfarin reversal.  J Clin Pathol. 2004;  57 1132-1139
  • 11 Hart R G, Boop B S, Anderson D C. Oral anticoagulants and intracranial hemorrhage. Facts and hypotheses.  Stroke. 1995;  26 1471-1477
  • 12 Hellstern P, Halbmayer W M, Kohler M, Seitz R, Muller-Berghaus G. Prothrombin complex concentrates: indications, contraindications, and risks: a task force summary.  Thromb Res. 1999;  95 S3-6
  • 13 Huttner H B, Steiner T. Coagulopathy-related intracerebral hemorrhage. In: Carhuapoma JR, Mayer SA, Hanley DF Textbook of Intracerebral Hemorrhage. Cambridge University Press; 2010: 58-70
  • 14 Morgenstern L B, Hemphill 3rd J C, Anderson C. et al . Guidelines for the Management of Spontaneous Intracerebral Hemorrhage. A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association.  Stroke. 2010;  41 2108-2129
  • 15 Pomper G J, Wu Y, Snyder E L. Risks of transfusion-transmitted infections: 2003.  Curr Opin Hematol. 2003;  10 412-418
  • 16 Rosand J, Eckman M H, Knudsen K A, Singer D E, Greenberg S M. The effect of warfarin and intensity of anticoagulation on outcome of intracerebral hemorrhage.  Arch Intern Med. 2004;  164 880-884
  • 17 Seitz R, Dodt J. Virus safety of prothrombin complex concentrates and factor IX concentrates.  Thromb Res. 1999;  95 S19-23
  • 18 Skolnick B E, Mathews D R, Khutoryansky N M, Pusateri A E, Carr M E. Exploratory study on the reversal of warfarin with rFVIIa in healthy subjects.  Blood. 2010;  116 693-701
  • 19 Steiner T, Forsting M, Haman G. et al .Intrazerebrale Blutungen. In: Diener H-C, Putzki N, Berlit P et al. Leitlinien für Diagnose und Therapie neurologischer Krankheiten. Thieme Verlag. Stuttgart; 2008: 317-333
  • 20 Steiner T, Kaste M, Forsting M. et al . Recommendations for the management of intracranial haemorrhage – part 1: spontaneous intracerebral haemorrhage. The European Stroke Initiative Writing Committee and the Writing Committee for the EUSI Executive Committee.  Cerebrovasc Dis. 2006;  22 294-316
  • 21 Tuhrim S, Horowitz D R, Sacher M, Godbold J H. Volume of ventricular blood is an important determinant of outcome in supratentorial intracerebral hemorrhage.  Crit Care Med. 1999;  27 617-621
  • 22 Yasaka M, Sakata T, Minematsu K, Naritomi H. Correction of INR by prothrombin complex concentrate and vitamin K in patients with warfarin related hemorrhagic complication.  Thromb Res. 2002;  108 25-30

Dr. Julian Bösel

Neurologische Klinik und Poliklinik
Universitätsklinikum Heidelberg

Im Neuenheimer Feld 400

69120 Heidelberg

Email: Julian.Boesel@med.uni-heidelberg.de

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