veterinär spiegel 2011; 21(01): 10-14
DOI: 10.1055/s-0030-1270721
Kleintiere & Heimtiere
Enke Verlag in MVS Medizinverlage Stuttgart GmbH & Co. KG Stuttgart

MDR1-Defekt – die 10 häufigsten Fragen

Doris Breu
,
Elisabeth Müller
Further Information

Publication History

Publication Date:
22 March 2011 (online)

Zoom Image

Tierärzte werden in der täglichen Routinepraxis zunehmend von besorgten Tierhaltern mit Fragen zu einem Gendefekt konfrontiert, der in der Hundepopulation innerhalb zahlreicher Rassen eine weite Verbreitung erfahren hat. Um eine Hilfestellung zu geben, wie im Vorfeld einer geplanten oder notwendigen tierärztlichen Behandlung Komplikationen auszuschließen sind, werden nachstehend die wichtigsten und häufigsten Fragen zum Thema MDR1-Gendefekt aufgeführt.

 
  • Literatur

  • 1 Barbet JL, Snook T, Gay JM, Mealey KL. ABCB1-1 (MDR1-1) genotype is associated with adverse reactions in dogs treated with milbemycin oxime for general demodicosis. The Authors. Journal compilation ESVD and ACD 2008; 20: 111-114
  • 2 Fassler PE, Tranquilli WJ, Paul AJ, Soll MD, Dipietro JA, Todd KS. Evaluation of the safety of ivermectin administered in a beef-based formulation to ivermectin-sensitive Collies. J Am Vet Med Assoc 1991; 199: 457-460
  • 3 Geyer J, Klintzsch S, Meerkamp K et al Detection of the nt 230 (del 4) MDR1 mutation in White Swiss Sheperd dogs: case reports of doramectin toxicosis, breed disposition and microsatellite analysis. J Vet Pharm Ther 2007; 30: 482-485
  • 4 Hopper K, Aldrich J, Haskins SC. Ivermectin toxicity in 17 Collies. J Vet Int Med 2002; 16: 89-94
  • 5 Mealey KL, Gay JM, Martin LG, Waiting DK. Comparison of the hypothalamic-pituitary-adrenal axis in MDR1-1 D and MDR1 wildtype dogs. J Vet Emergency Crit Care 2007; 17: 61-66
  • 6 Mealey KL, Bentjen SA, Gay JM, Cantor GH. Ivermectin sensitivity in collies is associated with a deletion mutation of the mdr1 gene. Pharmacogenetics 2001; 11: 727-733
  • 7 Mealey KL, Bentjen SA, Waiting DK. Frequency of the mutant MDR1 allele associated with ivermectin sensitivity in a sample population of Collies from the northwestern United States. Am J Vet Res 2002; 63: 479-481
  • 8 Mealey KL, Northrup NC, Bentjen SA. Increased toxicity of P-glycoprotein-substrate chemotherapeutic agents in a dog with the MDR1 deletion mutation associated with ivermectin sensitivity. J Am Vet Med Assoc 2003; 223: 1453-1455, 1434
  • 9 Meyer D. Therapie der caninen generalisierten Demodikose mit einem Moxidectin-Imidacloprid-Spot-on (Advocate®, Bayer). [Inaug.-Dissertation]. München: 2008
  • 10 Mueller RS, Hastie K, Bettenay SV. Daily oral ivermectin for treatment of generalised demodicosis in 23 dogs. Aust Vet Pract 1999; 29: 132-137
  • 11 Mueller RS, Bettenay SV. A proposed new therapeutic protocol for the treatment of canine mange with ivermectin. J AAHA 1999; 35: 77-80
  • 12 Nelson OL, Carsten E, Bentjen SA, Mealey KL. Ivermectin toxicity in an Australian shepherd dog with the MDR1 mutation associated with ivermectin sensitivity in collies. J Vet Int Med 2003; 17: 354-356
  • 13 Paul AJ, Tranquilli WJ, Seward RL, Todd KS, Dipietro JA. Clinical observations in Collies given ivermectin orally. Am J Vet Res 1987; 48: 684-685
  • 14 Paul AJ, Tranquilli WJ, Hutchens DE. Safety of moxidectin in avermectin-sensitive collies. Am J Vet Res 2000; 61: 482-483
  • 15 Petzinger EB, Döring J, Geyer J, Godoy U, Schirk D. Zahner. Arzneistofftransporter. Spiegel der Forschung 2005; 22: 26-33
  • 16 Sartor LL, Bentjen SA, Trepanier L, Mealey KL. Loperamide toxicity in a collie with the MDR1 mutation associated with ivermectin sensitivity. J Vet Int Med 2004; 18: 117-118
  • 17 Shoop WL, Mrozik H, Fisher MH. Structure and activity of avermectins and milbemycins in animal health. Veterinary Parasitology 1995; 59: 139-156
  • 18 Tranquilli WJ, Paul AJ, Todd KS. Assessment of toxicosis induced by high-dose administration of milbemycin oxime in Collies. Am J Vet Res 1991; 52: 1170-1177