Cerebrovascular Disease in Central Nervous System Infections

Felicia C Chow; Christina M Marra; Tracey A Cho

doi:10.1055/s-0031-1287658

Seminars in Neurology, Inhaltsverzeichnis

Semin Neurol 2011; 31(3): 286-306
DOI: 10.1055/s-0031-1287658

Cerebrovascular Disease in Central Nervous System Infections

Felicia C. Chow¹ ^, ² ^, ³ , Christina M. Marra⁴ , Tracey A. Cho¹ ^, ² ^, ³

¹Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts
²Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts
³Harvard Medical School, Boston, Massachusetts
⁴Department of Neurology, University of Washington, Seattle, Washington

Abstract

ABSTRACT

Cerebrovascular disease is a complication of a variety of infections affecting the central nervous system (CNS). Infection may cause vasculitis affecting primarily the vessels at the base of the brain in the setting of meningitis; an immune-mediated parainfectious process leading to vasospasm or thrombosis; or a hypercoagulable state in combination with endothelial dysfunction resulting from activation of inflammatory and procoagulant cascades. Although systemic signs and symptoms may be present to aid in the diagnosis, cerebral infarction secondary to infection may be indistinguishable from more typical causes of stroke. Confirmation of an infectious vasculitis may also be challenging, as brain biopsy, the gold standard for diagnosis, is rarely pursued. In many CNS infections, vascular complications portend a poor prognosis as they are often associated with devastating neurologic outcomes, including death, underscoring the importance of early recognition and appropriate therapy. In this review, we address bacterial, viral, fungal, and parasitic causes of cerebrovascular disease.

KEYWORDS

Stroke - vasculitis - vasculopathy - cerebrovascular - infection - meningitis - central nervous system

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Referenzen

REFERENCES

1 Kiechl S, Egger G, Mayr M et al.. Chronic infections and the risk of carotid atherosclerosis: prospective results from a large population study. Circulation. 2001; 103 (8) 1064-1070
2 Elkind M SV, Ramakrishnan P, Moon Y P et al.. Infectious burden and risk of stroke: the northern Manhattan study. Arch Neurol. 2010; 67 (1) 33-38
3 Grau A J, Brandt T. Do multiple chronic infections increase the risk of stroke?: the infectious burden concept. Arch Neurol. 2010; 67 (1) 16-17
4 Thigpen M C, Whitney C G, Messonnier N E Emerging Infections Programs Network et al. Bacterial meningitis in the United States, 1998-2007. N Engl J Med. 2011; 364 (21) 2016-2025
5 Durand M L, Calderwood S B, Weber D J et al.. Acute bacterial meningitis in adults. A review of 493 episodes. N Engl J Med. 1993; 328 (1) 21-28
6 Kastenbauer S, Pfister H W. Pneumococcal meningitis in adults: spectrum of complications and prognostic factors in a series of 87 cases. Brain. 2003; 126 (Pt 5) 1015-1025
7 Pfister H W, Borasio G D, Dirnagl U, Bauer M, Einhäupl K M. Cerebrovascular complications of bacterial meningitis in adults. Neurology. 1992; 42 (8) 1497-1504
8 Weststrate W, Hijdra A, de Gans J. Brain infarcts in adults with bacterial meningitis. Lancet. 1996; 347 (8998) 399
9 van de Beek D, de Gans J, Tunkel A R, Wijdicks E FM. Community-acquired bacterial meningitis in adults. N Engl J Med. 2006; 354 (1) 44-53
10 van de Beek D, de Gans J, Spanjaard L, Weisfelt M, Reitsma J B, Vermeulen M. Clinical features and prognostic factors in adults with bacterial meningitis. N Engl J Med. 2004; 351 (18) 1849-1859
11 Klein M, Koedel U, Kastenbauer S et al.. Delayed cerebral thrombosis after initial good recovery from pneumococcal meningitis: past as prologue: delayed stroke as a parainfectious process of bacterial meningitis?. Neurology. 2010; 75 (2) 193-194, author reply 193–194
12 van de Beek D, Patel R, Wijdicks E FM. Meningococcal meningitis with brainstem infarction. Arch Neurol. 2007; 64 (9) 1350-1351
13 Schut E S, Brouwer M C, de Gans J, Florquin S, Troost D, van de Beek D. Delayed cerebral thrombosis after initial good recovery from pneumococcal meningitis. Neurology. 2009; 73 (23) 1988-1995
14 Levi M, van der Poll T, Büller H R. Bidirectional relation between inflammation and coagulation. Circulation. 2004; 109 (22) 2698-2704
15 Vergouwen M DI, Schut E S, Troost D, van de Beek D. Diffuse cerebral intravascular coagulation and cerebral infarction in pneumococcal meningitis. Neurocrit Care. 2010; 13 (2) 217-227
16 Klein M, Koedel U, Kastenbauer S et al.. Delayed cerebral thrombosis after initial good recovery from pneumococcal meningitis: past as prologue: delayed stroke as a parainfectious process of bacterial meningitis?. Neurology. 2010; 75 (2) 193 author reply 193-194
17 Czartoski T, Hallam D, Lacy J M, Chun M R, Becker K. Postinfectious vasculopathy with evolution to moyamoya syndrome. J Neurol Neurosurg Psychiatry. 2005; 76 (2) 256-259
18 Pugin D, Copin J C, Goodyear M C, Landis T, Gasche Y. Persisting vasculitis after pneumococcal meningitis. Neurocrit Care. 2006; 4 (3) 237-240
19 Tunkel A R, Hartman B J, Kaplan S L et al.. Practice guidelines for the management of bacterial meningitis. Clin Infect Dis. 2004; 39 (9) 1267-1284
20 de Gans J, van de Beek D. European Dexamethasone in Adulthood Bacterial Meningitis Study Investigators . Dexamethasone in adults with bacterial meningitis. N Engl J Med. 2002; 347 (20) 1549-1556
21 van de Beek D, Farrar J J, de Gans J et al.. Adjunctive dexamethasone in bacterial meningitis: a meta-analysis of individual patient data. Lancet Neurol. 2010; 9 (3) 254-263
22 Brouwer M C, Heckenberg S G, de Gans J, Spanjaard L, Reitsma J B, van de Beek D. Nationwide implementation of adjunctive dexamethasone therapy for pneumococcal meningitis. Neurology. 2010; 75 (17) 1533-1539
23 Brouwer M C, McIntyre P, de Gans J, Prasad K, van de Beek D. Corticosteroids for acute bacterial meningitis. Cochrane Database Syst Rev. 2010; (9) CD004405
24 van de Beek D, Weisfelt M, de Gans J, Tunkel A R, Wijdicks E FM. Drug insight: adjunctive therapies in adults with bacterial meningitis. Nat Clin Pract Neurol. 2006; 2 (9) 504-516
25 World Health Organization .Global tuberculosis control 2010. Available at: http://www.who.int/tb/publications/global_report/2010/en/index.html Accessed June 1, 2011
26 Christensen A S, Andersen A B, Thomsen V O, Andersen P H, Johansen I S. Tuberculous meningitis in Denmark: a review of 50 cases. BMC Infect Dis. 2011; 11 47
27 Centers for Disease Control and Prevention .Reported tuberculosis in the United States 2009. Available at: http://www.cdc.gov/tb/statistics/reports/2009/pdf/report2009.pdf Accessed June 1, 2011
28 Ogawa S K, Smith M A, Brennessel D J, Lowy F D. Tuberculous meningitis in an urban medical center. Medicine (Baltimore). 1987; 66 (4) 317-326
29 Kent S J, Crowe S M, Yung A, Lucas C R, Mijch A M. Tuberculous meningitis: a 30-year review. Clin Infect Dis. 1993; 17 (6) 987-994
30 Girgis N I, Sultan Y, Farid Z et al.. Tuberculosis meningitis, Abbassia Fever Hospital-Naval Medical Research Unit No. 3-Cairo, Egypt, from 1976 to 1996. Am J Trop Med Hyg. 1998; 58 (1) 28-34
31 Thwaites G, Fisher M, Hemingway C, Scott G, Solomon T, Innes J. British Infection Society . British Infection Society guidelines for the diagnosis and treatment of tuberculosis of the central nervous system in adults and children. J Infect. 2009; 59 (3) 167-187
32 Dastur D K, Manghani D K, Udani P M. Pathology and pathogenetic mechanisms in neurotuberculosis. Radiol Clin North Am. 1995; 33 (4) 733-752
33 Katrak S M. Vasculitis and stroke due to tuberculosis. In: Caplan L R, ed. Uncommon Causes of Stroke. 2nd ed. New York: Cambridge University Press; 2008: 41-45
34 Lammie G A, Hewlett R H, Schoeman J F, Donald P R. Tuberculous cerebrovascular disease: a review. J Infect. 2009; 59 (3) 156-166
35 Misra U K, Kalita J, Maurya P K. Stroke in tuberculous meningitis. J Neurol Sci. 2011; 303 (1-2) 22-30
36 Shukla R, Abbas A, Kumar P, Gupta R K, Jha S, Prasad K N. Evaluation of cerebral infarction in tuberculous meningitis by diffusion weighted imaging. J Infect. 2008; 57 (4) 298-306
37 Donald P R, Schoeman J F. Tuberculous meningitis. N Engl J Med. 2004; 351 (17) 1719-1720
38 Kalita J, Misra U K, Nair P P. Predictors of stroke and its significance in the outcome of tuberculous meningitis. J Stroke Cerebrovasc Dis. 2009; 18 (4) 251-258
39 Dalal P M, Dalal K P. Subcortical and lacunar infarctions in neurotuberculosis. In: Donnan G A, Norrving B, Bamford J M, Bogousslvsky J, eds. Lacunar and Other Subcortical Infarctions. New York: Oxford University Press; 1995: 219-230
40 Rich A R, McCordock H A. The pathogenesis of tuberculous meningitis. Bull Johns Hopkins Hosp. 1933; 53 5-37
41 Brown E, Gray F. Bacterial infections. In: Love S, Louis D N, Ellison D W, eds. Greenfield's Neuropathology. 8th ed. London: Hodder Arnold; 2008: 1391-1445
42 Dalal P M. Observations on the involvement of cerebral vessels in tuberculous meningitis in adults. Adv Neurol. 1979; 25 149-159
43 Rojas-Echeverri L A, Soto-Hernández J L, Garza S et al.. Predictive value of digital subtraction angiography in patients with tuberculous meningitis. Neuroradiology. 1996; 38 (1) 20-24
44 Sütlaş P N, Unal A, Forta H, Senol S, Kirbaş D. Tuberculous meningitis in adults: review of 61 cases. Infection. 2003; 31 (6) 387-391
45 Jeren T, Beus I. Characteristics of cerebrospinal fluid in tuberculous meningitis. Acta Cytol. 1982; 26 (5) 678-680
46 Thwaites G E, Chau T T, Stepniewska K et al.. Diagnosis of adult tuberculous meningitis by use of clinical and laboratory features. Lancet. 2002; 360 (9342) 1287-1292
47 Zuger A. Tuberculosis. In: Scheld W M, Whitley R J, Marra C M, eds. Infections of the Central Nervous System. 3rd ed. Philadelphia: Lippincott Williams and Wilkins; 2004: 441-459
48 Verdon R, Chevret S, Laissy J P, Wolff M. Tuberculous meningitis in adults: review of 48 cases. Clin Infect Dis. 1996; 22 (6) 982-988
49 Thwaites G E, Chau T T, Farrar J J. Improving the bacteriological diagnosis of tuberculous meningitis. J Clin Microbiol. 2004; 42 (1) 378-379
50 Thwaites G E, Caws M, Chau T T et al.. Comparison of conventional bacteriology with nucleic acid amplification (amplified mycobacterium direct test) for diagnosis of tuberculous meningitis before and after inception of antituberculosis chemotherapy. J Clin Microbiol. 2004; 42 (3) 996-1002
51 Pai M, Flores L L, Pai N, Hubbard A, Riley L W, Colford Jr J M. Diagnostic accuracy of nucleic acid amplification tests for tuberculous meningitis: a systematic review and meta-analysis. Lancet Infect Dis. 2003; 3 (10) 633-643
52 Hsieh F Y, Chia L G, Shen W C. Locations of cerebral infarctions in tuberculous meningitis. Neuroradiology. 1992; 34 (3) 197-199
53 Nair P P, Kalita J, Kumar S, Misra U K. MRI pattern of infarcts in basal ganglia region in patients with tuberculous meningitis. Neuroradiology. 2009; 51 (4) 221-225
54 Greitz T. Angiography in tuberculous meningitis. Acta Radiol Diagn (Stockh). 1964; 2 369-378
55 Lehrer H. The angiographic triad in tuberculous meningitis. A radiographic and clinicopathologic correlation. Radiology. 1966; 87 (5) 829-835
56 Mathew N T, Abraham J, Chandy J. Cerebral angiographic features in tuberculous meningitis. Neurology. 1970; 20 (10) 1015-1023
57 Koh S B, Kim B J, Park M H, Yu S W, Park K W, Lee D H. Clinical and laboratory characteristics of cerebral infarction in tuberculous meningitis: a comparative study. J Clin Neurosci. 2007; 14 (11) 1073-1077
58 Misra U K, Kalita J, Roy A K, Mandal S K, Srivastava M. Role of clinical, radiological, and neurophysiological changes in predicting the outcome of tuberculous meningitis: a multivariable analysis. J Neurol Neurosurg Psychiatry. 2000; 68 (3) 300-303
59 Berenguer J, Moreno S, Laguna F et al.. Tuberculous meningitis in patients infected with the human immunodeficiency virus. N Engl J Med. 1992; 326 (10) 668-672
60 Dubé M P, Holtom P D, Larsen R A. Tuberculous meningitis in patients with and without human immunodeficiency virus infection. Am J Med. 1992; 93 (5) 520-524
61 Porkert M T, Sotir M, Parrott-Moore P, Blumberg H M. Tuberculous meningitis at a large inner-city medical center. Am J Med Sci. 1997; 313 (6) 325-331
62 Yechoor V K, Shandera W X, Rodriguez P, Cate T R. Tuberculous meningitis among adults with and without HIV infection. Experience in an urban public hospital. Arch Intern Med. 1996; 156 (15) 1710-1716
63 Schutte C M. Clinical, cerebrospinal fluid and pathological findings and outcomes in HIV-positive and HIV-negative patients with tuberculous meningitis. Infection. 2001; 29 (4) 213-217
64 van der Weert E M, Hartgers N M, Schaaf H S et al.. Comparison of diagnostic criteria of tuberculous meningitis in human immunodeficiency virus-infected and uninfected children. Pediatr Infect Dis J. 2006; 25 (1) 65-69
65 Jarvis J N, Meintjes G, Williams A, Brown Y, Crede T, Harrison T S. Adult meningitis in a setting of high HIV and TB prevalence: findings from 4961 suspected cases. BMC Infect Dis. 2010; 10 67
66 Katrak S M, Shembalkar P K, Bijwe S R, Bhandarkar L D. The clinical, radiological and pathological profile of tuberculous meningitis in patients with and without human immunodeficiency virus infection. J Neurol Sci. 2000; 181 (1-2) 118-126
67 Thwaites G E, Duc Bang N, Huy Dung N et al.. The influence of HIV infection on clinical presentation, response to treatment, and outcome in adults with tuberculous meningitis. J Infect Dis. 2005; 192 (12) 2134-2141
68 Jones B E, Young S M, Antoniskis D, Davidson P T, Kramer F, Barnes P F. Relationship of the manifestations of tuberculosis to CD4 cell counts in patients with human immunodeficiency virus infection. Am Rev Respir Dis. 1993; 148 (5) 1292-1297
69 American Thoracic Society . Treatment of tuberculosis. MMWR Recomm Rep. 2003; 52 (RR-11) 1-77
70 Thwaites G E, Nguyen D B, Nguyen H D et al.. Dexamethasone for the treatment of tuberculous meningitis in adolescents and adults. N Engl J Med. 2004; 351 (17) 1741-1751
71 Prasad K, Singh M B. Corticosteroids for managing tuberculous meningitis. Cochrane Database Syst Rev. 2008; (1) CD002244
72 Marais S, Pepper D J, Schutz C, Wilkinson R J, Meintjes G. Presentation and outcome of tuberculous meningitis in a high HIV prevalence setting. PLoS ONE. 2011; 6 (5) e20077
73 Teoh R, Humphries M J, O'Mahony G. Symptomatic intracranial tuberculoma developing during treatment of tuberculosis: a report of 10 patients and review of the literature. Q J Med. 1987; 63 (241) 449-460
74 Narita M, Ashkin D, Hollender E S, Pitchenik A E. Paradoxical worsening of tuberculosis following antiretroviral therapy in patients with AIDS. Am J Respir Crit Care Med. 1998; 158 (1) 157-161
75 Pepper D J, Marais S, Maartens G et al.. Neurologic manifestations of paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome: a case series. Clin Infect Dis. 2009; 48 (11) e96-e107
76 Thwaites G E, Macmullen-Price J, Tran T H et al.. Serial MRI to determine the effect of dexamethasone on the cerebral pathology of tuberculous meningitis: an observational study. Lancet Neurol. 2007; 6 (3) 230-236
77 Misra U K, Kalita J, Nair P P. Role of aspirin in tuberculous meningitis: a randomized open label placebo controlled trial. J Neurol Sci. 2010; 293 (1-2) 12-17
78 CDC .Syphilis. Sexually Transmitted Diseases 2009. Available at: http://www.cdc.gov/std/stats09/syphilis.htm Accessed May 25, 2011
79 Lukehart S A, Hook III E W, Baker-Zander S A, Collier A C, Critchlow C W, Handsfield H H. Invasion of the central nervous system by Treponema pallidum: implications for diagnosis and treatment. Ann Intern Med. 1988; 109 (11) 855-862
80 Rolfs R T, Joesoef M R, Hendershot E F The Syphilis and HIV Study Group et al. A randomized trial of enhanced therapy for early syphilis in patients with and without human immunodeficiency virus infection. N Engl J Med. 1997; 337 (5) 307-314
81 Merrit H H, Adams R D, Solomon H C. Neurosyphilis. New York: Oxford University Press; 1946
82 Burke J M, Schaberg D R. Neurosyphilis in the antibiotic era. Neurology. 1985; 35 (9) 1368-1371
83 Stokes J H, Beerman H, Ingraham N R. Modern Clinical Sphilology: Diagnosis, Treatment, Case Study. Philadelphia: WB Saunders; 1944
84 Timmermans M, Carr J. Neurosyphilis in the modern era. J Neurol Neurosurg Psychiatry. 2004; 75 (12) 1727-1730
85 Musher D M. Syphilis, neurosyphilis, penicillin, and AIDS. J Infect Dis. 1991; 163 (6) 1201-1206
86 Holmes M D, Brant-Zawadzki M M, Simon R P. Clinical features of meningovascular syphilis. Neurology. 1984; 34 (4) 553-556
87 Harriman D GF. Bacterial infections of the central nervous system. In: Blackwood W, Corsellis J AN, eds. Greenfield's Neuropathology. 3rd ed. Chicago: Yearbook Medical Publishers; 1976: 238-268
88 Vatz K A, Scheibel R L, Keiffer S A, Ansari K A. Neurosyphilis and diffuse cerebral angiopathy: a case report. Neurology. 1974; 24 (5) 472-476
89 Winkelman N W, Eckel J L. Productive endarteritis of the small cortical vessels in severe toxemias. Brain. 1927; 50 (3–4) 608-623
90 Davis L E, Schmitt J W. Clinical significance of cerebrospinal fluid tests for neurosyphilis. Ann Neurol. 1989; 25 (1) 50-55
91 Workowski K A, Berman S M. Centers for Disease Control and Prevention . Sexually transmitted diseases treatment guidelines, 2006. MMWR Recomm Rep. 2006; 55 (RR-11) 1-94
92 Jaffe H W, Larsen S A, Peters M, Jove D F, Lopez B, Schroeter A L. Tests for treponemal antibody in CSF. Arch Intern Med. 1978; 138 (2) 252-255
93 Simon R P. Neurosyphilis. Arch Neurol. 1985; 42 (6) 606-613
94 Marra C M, Maxwell C L, Collier A C, Robertson K R, Imrie A. Interpreting cerebrospinal fluid pleocytosis in HIV in the era of potent antiretroviral therapy. BMC Infect Dis. 2007; 7 37
95 Berry C D, Hooton T M, Collier A C, Lukehart S A. Neurologic relapse after benzathine penicillin therapy for secondary syphilis in a patient with HIV infection. N Engl J Med. 1987; 316 (25) 1587-1589
96 Johns D R, Tierney M, Felsenstein D. Alteration in the natural history of neurosyphilis by concurrent infection with the human immunodeficiency virus. N Engl J Med. 1987; 316 (25) 1569-1572
97 Katz D A, Berger J R, Duncan R C. Neurosyphilis. A comparative study of the effects of infection with human immunodeficiency virus. Arch Neurol. 1993; 50 (3) 243-249
98 Centers for Disease Control and Prevention (CDC) . Symptomatic early neurosyphilis among HIV-positive men who have sex with men—four cities, United States, January 2002-June 2004. MMWR Morb Mortal Wkly Rep. 2007; 56 (25) 625-628
99 Chang C C, Leslie D E, Spelman D et al.. Symptomatic and asymptomatic early neurosyphilis in HIV-infected men who have sex with men: a retrospective case series from 2000 to 2007. Sex Health. 2011; 8 (2) 207-213
100 Bucher J B, Golden M R, Heald A E, Marra C M. Stroke in a patient with human immunodeficiency virus and syphilis treated with penicillin and antiretroviral therapy. Sex Transm Dis. 2010; November 30 (Epub ahead of print)
101 Marra C M, Maxwell C L, Smith S L et al.. Cerebrospinal fluid abnormalities in patients with syphilis: association with clinical and laboratory features. J Infect Dis. 2004; 189 (3) 369-376
102 Guidelines for prevention and treatment of opportunistic infections in HIV-infected adults and adolescents. 2008. Available at: http://AIDSinfo.nih.gov Accessed May 28, 2009
103 Ghanem K G, Erbelding E J, Wiener Z S, Rompalo A M. Serological response to syphilis treatment in HIV-positive and HIV-negative patients attending sexually transmitted diseases clinics. Sex Transm Infect. 2007; 83 (2) 97-101
104 Kelley R E, Minagar A, Kelley B J, Brunson R. Trancranial Doppler monitoring of response to therapy for meningovascular syphilis. J Neuroimaging. 2003; 13 (1) 85-87
105 Davis L E, Graham G D. Neurosyphilis and stroke. In: Caplan L R, ed. Uncommon Causes of Stroke. 2nd ed. New York: Cambridge University Press; 2008: 35-39
106 Askalan R, Laughlin S, Mayank S et al.. Chickenpox and stroke in childhood: a study of frequency and causation. Stroke. 2001; 32 (6) 1257-1262
107 Lanthier S, Armstrong D, Domi T, deVeber G. Post-varicella arteriopathy of childhood: natural history of vascular stenosis. Neurology. 2005; 64 (4) 660-663
108 Miravet E, Danchaivijitr N, Basu H, Saunders D E, Ganesan V. Clinical and radiological features of childhood cerebral infarction following varicella zoster virus infection. Dev Med Child Neurol. 2007; 49 (6) 417-422
109 Manco-Johnson M J, Nuss R, Key N et al.. Lupus anticoagulant and protein S deficiency in children with postvaricella purpura fulminans or thrombosis. J Pediatr. 1996; 128 (3) 319-323
110 Massano J, Ferreira D, Toledo T, Mansilha A, Azevedo E, Carvalho M. Stroke and multiple peripheral thrombotic events in an adult with varicella. Eur J Neurol. 2008; 15 (10) e90-e91
111 Josephson C, Nuss R, Jacobson L et al.. The varicella-autoantibody syndrome. Pediatr Res. 2001; 50 (3) 345-352
112 Amlie-Lefond C, Jubelt B. Neurologic manifestations of varicella zoster virus infections. Curr Neurol Neurosci Rep. 2009; 9 (6) 430-434
113 Reshef E, Greenberg S B, Jankovic J. Herpes zoster ophthalmicus followed by contralateral hemiparesis: report of two cases and review of literature. J Neurol Neurosurg Psychiatry. 1985; 48 (2) 122-127
114 Hilt D C, Buchholz D, Krumholz A, Weiss H, Wolinsky J S. Herpes zoster ophthalmicus and delayed contralateral hemiparesis caused by cerebral angiitis: diagnosis and management approaches. Ann Neurol. 1983; 14 (5) 543-553
115 Nagel M A, Cohrs R J, Mahalingam R et al.. The varicella zoster virus vasculopathies: clinical, CSF, imaging, and virologic features. Neurology. 2008; 70 (11) 853-860
116 Gray F, Bélec L, Lescs M C et al.. Varicella-zoster virus infection of the central nervous system in the acquired immune deficiency syndrome. Brain. 1994; 117 (Pt 5) 987-999
117 Nagel M A, Mahalingam R, Cohrs R J, Gilden D. Virus vasculopathy and stroke: an under-recognized cause and treatment target. Infect Disord Drug Targets. 2010; 10 (2) 105-111
118 Nagel M A, Forghani B, Mahalingam R et al.. The value of detecting anti-VZV IgG antibody in CSF to diagnose VZV vasculopathy. Neurology. 2007; 68 (13) 1069-1073
119 Katchanov J, Siebert E, Klingebiel R, Endres M. Infectious vasculopathy of intracranial large- and medium-sized vessels in neurological intensive care unit: a clinico-radiological study. Neurocrit Care. 2010; 12 (3) 369-374
120 Schmidbauer M, Budka H, Pilz P, Kurata T, Hondo R. Presence, distribution and spread of productive varicella zoster virus infection in nervous tissues. Brain. 1992; 115 (Pt 2) 383-398
121 Kleinschmidt-DeMasters B K, Amlie-Lefond C, Gilden D H. The patterns of varicella zoster virus encephalitis. Hum Pathol. 1996; 27 (9) 927-938
122 Ruppenthal M. Changes of the central nervous system in herpes zoster. Acta Neuropathol. 1980; 52 (1) 59-68
123 Gilden D H, Kleinschmidt-DeMasters B K, LaGuardia J J, Mahalingam R, Cohrs R J. Neurologic complications of the reactivation of varicella-zoster virus. N Engl J Med. 2000; 342 (9) 635-645
124 Gilden D, Cohrs R J, Mahalingam R, Nagel M A. Varicella zoster virus vasculopathies: diverse clinical manifestations, laboratory features, pathogenesis, and treatment. Lancet Neurol. 2009; 8 (8) 731-740
125 Newsome S D, Nath A. Varicella-zoster virus vasculopathy and central nervous system immune reconstitution inflammatory syndrome with human immunodeficiency virus infection treated with steroids. J Neurovirol. 2009; 15 (3) 288-291
126 Oxman M N, Levin M J, Johnson G R Shingles Prevention Study Group et al. A vaccine to prevent herpes zoster and postherpetic neuralgia in older adults. N Engl J Med. 2005; 352 (22) 2271-2284
127 Triant V A, Lee H, Hadigan C, Grinspoon S K. Increased acute myocardial infarction rates and cardiovascular risk factors among patients with human immunodeficiency virus disease. J Clin Endocrinol Metab. 2007; 92 (7) 2506-2512
128 Currier J S, Taylor A, Boyd F et al.. Coronary heart disease in HIV-infected individuals. J Acquir Immune Defic Syndr. 2003; 33 (4) 506-512
129 Friis-Møller N, Sabin C A, Weber R Data Collection on Adverse Events of Anti-HIV Drugs (DAD) Study Group et al. Combination antiretroviral therapy and the risk of myocardial infarction. N Engl J Med. 2003; 349 (21) 1993-2003
130 Berger J R, Harris J O, Gregorios J, Norenberg M. Cerebrovascular disease in AIDS: a case-control study. AIDS. 1990; 4 (3) 239-244
131 Cole J W, Pinto A N, Hebel J R et al.. Acquired immunodeficiency syndrome and the risk of stroke. Stroke. 2004; 35 (1) 51-56
132 Engstrom J W, Lowenstein D H, Bredesen D E. Cerebral infarctions and transient neurologic deficits associated with acquired immunodeficiency syndrome. Am J Med. 1989; 86 (5) 528-532
133 Pinto A N. AIDS and cerebrovascular disease. Stroke. 1996; 27 (3) 538-543
134 Anders K H, Guerra W F, Tomiyasu U, Verity M A, Vinters H V. The neuropathology of AIDS. UCLA experience and review. Am J Pathol. 1986; 124 (3) 537-558
135 Mizusawa H, Hirano A, Llena J F, Shintaku M. Cerebrovascular lesions in acquired immune deficiency syndrome (AIDS). Acta Neuropathol. 1988; 76 (5) 451-457
136 Connor M D, Lammie G A, Bell J E, Warlow C P, Simmonds P, Brettle R D. Cerebral infarction in adult AIDS patients: observations from the Edinburgh HIV Autopsy Cohort. Stroke. 2000; 31 (9) 2117-2126
137 Gray F, Gherardi R, Scaravilli F. The neuropathology of the acquired immune deficiency syndrome (AIDS). A review. Brain. 1988; 111 (Pt 2) 245-266
138 Evers S, Nabavi D, Rahmann A, Heese C, Reichelt D, Husstedt I W. Ischaemic cerebrovascular events in HIV infection: a cohort study. Cerebrovasc Dis. 2003; 15 (3) 199-205
139 Corral I, Quereda C, Moreno A et al.. Cerebrovascular ischemic events in HIV-1-infected patients receiving highly active antiretroviral therapy: incidence and risk factors. Cerebrovasc Dis. 2009; 27 (6) 559-563
140 Berger J R. AIDS and stroke risk. Lancet Neurol. 2004; 3 (4) 206-207
141 Ovbiagele B, Nath A. Increasing incidence of ischemic stroke in patients with HIV infection. Neurology. 2011; January 19 (Epub ahead of print)
142 Chetty R. Vasculitides associated with HIV infection. J Clin Pathol. 2001; 54 (4) 275-278
143 Calabrese L H, Estes M, Yen-Lieberman B et al.. Systemic vasculitis in association with human immunodeficiency virus infection. Arthritis Rheum. 1989; 32 (5) 569-576
144 Calabrese L H. Vasculitis and infection with the human immunodeficiency virus. Rheum Dis Clin North Am. 1991; 17 (1) 131-147
145 Anders K H, Latta H, Chang B S, Tomiyasu U, Quddusi A S, Vinters H V. Lymphomatoid granulomatosis and malignant lymphoma of the central nervous system in the acquired immunodeficiency syndrome. Hum Pathol. 1989; 20 (4) 326-334
146 Calabrese L H. Infection with the human immunodeficiency virus type 1 and vascular inflammatory disease. Clin Exp Rheumatol. 2004; 22 (6, Suppl 36) S87-S93
147 Nogueras C, Sala M, Sasal M et al.. Recurrent stroke as a manifestation of primary angiitis of the central nervous system in a patient infected with human immunodeficiency virus. Arch Neurol. 2002; 59 (3) 468-473
148 Melica G, Brugieres P, Lascaux A S, Levy Y, Lelièvre J D. Primary vasculitis of the central nervous system in patients infected with HIV-1 in the HAART era. J Med Virol. 2009; 81 (4) 578-581
149 Frank Y, Lim W, Kahn E, Farmer P, Gorey M, Pahwa S. Multiple ischemic infarcts in a child with AIDS, varicella zoster infection, and cerebral vasculitis. Pediatr Neurol. 1989; 5 (1) 64-67
150 Yankner B A, Skolnik P R, Shoukimas G M, Gabuzda D H, Sobel R A, Ho D D. Cerebral granulomatous angiitis associated with isolation of human T-lymphotropic virus type III from the central nervous system. Ann Neurol. 1986; 20 (3) 362-364
151 Bhagavati S, Choi J. Rapidly progressive cerebrovascular stenosis and recurrent strokes followed by improvement in HIV vasculopathy. Cerebrovasc Dis. 2008; 26 (4) 449-452
152 Gillams A R, Allen E, Hrieb K, Venna N, Craven D, Carter A P. Cerebral infarction in patients with AIDS. AJNR Am J Neuroradiol. 1997; 18 (8) 1581-1585
153 Vinters H V, Guerra W F, Eppolito L, Keith III P E. Necrotizing vasculitis of the nervous system in a patient with AIDS-related complex. Neuropathol Appl Neurobiol. 1988; 14 (5) 417-424
154 Scaravilli F, Daniel S E, Harcourt-Webster N, Guiloff R J. Chronic basal meningitis and vasculitis in acquired immunodeficiency syndrome. A possible role for human immunodeficiency virus. Arch Pathol Lab Med. 1989; 113 (2) 192-195
155 Burns D K. The neuropathology of pediatric acquired immunodeficiency syndrome. J Child Neurol. 1992; 7 (4) 332-346
156 Park Y D, Belman A L, Kim T S et al.. Stroke in pediatric acquired immunodeficiency syndrome. Ann Neurol. 1990; 28 (3) 303-311
157 Dubrovsky T, Curless R, Scott G et al.. Cerebral aneurysmal arteriopathy in childhood AIDS. Neurology. 1998; 51 (2) 560-565
158 Martínez-Longoria C A, Morales-Aguirre J J, Villalobos-Acosta C P, Gómez-Barreto D, Cashat-Cruz M. Occurrence of intracerebral aneurysm in an HIV-infected child: a case report. Pediatr Neurol. 2004; 31 (2) 130-132
159 Mazzoni P, Chiriboga C A, Millar W S, Rogers A. Intracerebral aneurysms in human immunodeficiency virus infection: case report and literature review. Pediatr Neurol. 2000; 23 (3) 252-255
160 Patsalides A D, Wood L V, Atac G K, Sandifer E, Butman J A, Patronas N J. Cerebrovascular disease in HIV-infected pediatric patients: neuroimaging findings. AJR Am J Roentgenol. 2002; 179 (4) 999-1003
161 Chetty R, Batitang S, Nair R. Large artery vasculopathy in HIV-positive patients: another vasculitic enigma. Hum Pathol. 2000; 31 (3) 374-379
162 Tipping B, de Villiers L, Candy S, Wainwright H. Stroke caused by human immunodeficiency virus-associated intracranial large-vessel aneurysmal vasculopathy. Arch Neurol. 2006; 63 (11) 1640-1642
163 Tipping B, de Villiers L, Wainwright H, Candy S, Bryer A. Stroke in patients with human immunodeficiency virus infection. J Neurol Neurosurg Psychiatry. 2007; 78 (12) 1320-1324
164 Qureshi A I, Janssen R S, Karon J M et al.. Human immunodeficiency virus infection and stroke in young patients. Arch Neurol. 1997; 54 (9) 1150-1153
165 Mochan A, Modi M, Modi G. Stroke in black South African HIV-positive patients: a prospective analysis. Stroke. 2003; 34 (1) 10-15
166 Mochan A, Modi M, Modi G. Protein S deficiency in HIV associated ischaemic stroke: an epiphenomenon of HIV infection. J Neurol Neurosurg Psychiatry. 2005; 76 (10) 1455-1456
167 Ortiz G, Koch S, Romano J G, Forteza A M, Rabinstein A A. Mechanisms of ischemic stroke in HIV-infected patients. Neurology. 2007; 68 (16) 1257-1261
168 Stein J H. Dyslipidemia in the era of HIV protease inhibitors. Prog Cardiovasc Dis. 2003; 45 (4) 293-304
169 Walli R, Herfort O, Michl G M et al.. Treatment with protease inhibitors associated with peripheral insulin resistance and impaired oral glucose tolerance in HIV-1-infected patients. AIDS. 1998; 12 (15) F167-F173
170 Périard D, Telenti A, Sudre P et al.. Atherogenic dyslipidemia in HIV-infected individuals treated with protease inhibitors. The Swiss HIV Cohort Study. Circulation. 1999; 100 (7) 700-705
171 Carr A. HIV lipodystrophy: risk factors, pathogenesis, diagnosis and management. AIDS. 2003; 17 (Suppl 1) S141-S148
172 Chen D, Misra A, Garg A. Clinical review 153: Lipodystrophy in human immunodeficiency virus-infected patients. J Clin Endocrinol Metab. 2002; 87 (11) 4845-4856
173 Saif M W, Bona R, Greenberg B. AIDS and thrombosis: retrospective study of 131 HIV-infected patients. AIDS Patient Care STDS. 2001; 15 (6) 311-320
174 Fantoni M, Del Borgo C, Autore C. Evaluation and management of metabolic and coagulative disorders in HIV-infected patients receiving highly active antiretroviral therapy. AIDS. 2003; 17 (Suppl 1) S162-S169
175 Bozzette S A, Ake C F, Tam H K et al.. Long-term survival and serious cardiovascular events in HIV-infected patients treated with highly active antiretroviral therapy. J Acquir Immune Defic Syndr. 2008; 47 (3) 338-341
176 Currier J S, Kendall M A, Zackin R AACTG 5078 Study Team et al. Carotid artery intima-media thickness and HIV infection: traditional risk factors overshadow impact of protease inhibitor exposure. AIDS. 2005; 19 (9) 927-933
177 El-Sadr W M, Lundgren J D, Neaton J D Strategies for Management of Antiretroviral Therapy (SMART) Study Group et al. CD4 + count-guided interruption of antiretroviral treatment. N Engl J Med. 2006; 355 (22) 2283-2296
178 Mercié P, Thiébaut R, Lavignolle V et al.. Evaluation of cardiovascular risk factors in HIV-1 infected patients using carotid intima-media thickness measurement. Ann Med. 2002; 34 (1) 55-63
179 Seaberg E C, Benning L, Sharrett A R et al.. Association between human immunodeficiency virus infection and stiffness of the common carotid artery. Stroke. 2010; 41 (10) 2163-2170
180 Denning D W. Invasive aspergillosis. Clin Infect Dis. 1998; 26 (4) 781-803 quiz 804-805
181 Torre-Cisneros J, Lopez O L, Kusne S et al.. CNS aspergillosis in organ transplantation: a clinicopathological study. J Neurol Neurosurg Psychiatry. 1993; 56 (2) 188-193
182 Walsh T J, Hier D B, Caplan L R. Aspergillosis of the central nervous system: clinicopathological analysis of 17 patients. Ann Neurol. 1985; 18 (5) 574-582
183 Hori A, Kami M, Kishi Y, Machida U, Matsumura T, Kashima T. Clinical significance of extra-pulmonary involvement of invasive aspergillosis: a retrospective autopsy-based study of 107 patients. J Hosp Infect. 2002; 50 (3) 175-182
184 Kleinschmidt-DeMasters B K. Central nervous system aspergillosis: a 20-year retrospective series. Hum Pathol. 2002; 33 (1) 116-124
185 Pongbhaesaj P, Dejthevaporn C, Tunlayadechanont S, Witoonpanich R, Sungkanuparph S, Vibhagool A. Aspergillosis of the central nervous system: a catastrophic opportunistic infection. Southeast Asian J Trop Med Public Health. 2004; 35 (1) 119-125
186 Lin S J, Schranz J, Teutsch S M. Aspergillosis case-fatality rate: systematic review of the literature. Clin Infect Dis. 2001; 32 (3) 358-366
187 Denning D W. Therapeutic outcome in invasive aspergillosis. Clin Infect Dis. 1996; 23 (3) 608-615
188 Schwartz S, Thiel E. Update on the treatment of cerebral aspergillosis. Ann Hematol. 2004; 83 (Suppl 1) S42-S44
189 Sood S, Sharma R, Gupta S, Pathak D, Rishi S. Neuroaspergillosis in an immunocompetent patient. Indian J Med Microbiol. 2007; 25 (1) 67-69
190 Martins H S, da Silva T R, Scalabrini-Neto A, Velasco I T. Cerebral vasculitis caused by Aspergillus simulating ischemic stroke in an immunocompetent patient. J Emerg Med. 2010; 38 (5) 597-600
191 Murthy J M, Sundaram C, Prasad V S, Purohit A K, Rammurti S, Laxmi V. Aspergillosis of central nervous system: a study of 21 patients seen in a university hospital in south India. J Assoc Physicians India. 2000; 48 (7) 677-681
192 Ho C L, Deruytter M J. CNS aspergillosis with mycotic aneurysm, cerebral granuloma and infarction. Acta Neurochir (Wien). 2004; 146 (8) 1-6
193 Hagensee M E, Bauwens J E, Kjos B, Bowden R A. Brain abscess following marrow transplantation: experience at the Fred Hutchinson Cancer Research Center, 1984-1992. Clin Infect Dis. 1994; 19 (3) 402-408
194 Hummel M, Spiess B, Kentouche K et al.. Detection of Aspergillus DNA in cerebrospinal fluid from patients with cerebral aspergillosis by a nested PCR assay. J Clin Microbiol. 2006; 44 (11) 3989-3993
195 Kami M, Shirouzu I, Mitani K et al.. Early diagnosis of central nervous system aspergillosis with combination use of cerebral diffusion-weighted echo-planar magnetic resonance image and polymerase chain reaction of cerebrospinal fluid. Intern Med. 1999; 38 (1) 45-48
196 Wheat L J. Rapid diagnosis of invasive aspergillosis by antigen detection. Transpl Infect Dis. 2003; 5 (4) 158-166
197 Musher B, Fredricks D, Leisenring W, Balajee S A, Smith C, Marr K A. Aspergillus galactomannan enzyme immunoassay and quantitative PCR for diagnosis of invasive aspergillosis with bronchoalveolar lavage fluid. J Clin Microbiol. 2004; 42 (12) 5517-5522
198 Persat F, Ranque S, Derouin F, Michel-Nguyen A, Picot S, Sulahian A. Contribution of the (1→3)-beta-D-glucan assay for diagnosis of invasive fungal infections. J Clin Microbiol. 2008; 46 (3) 1009-1013
199 Viscoli C, Machetti M, Gazzola P et al.. Aspergillus galactomannan antigen in the cerebrospinal fluid of bone marrow transplant recipients with probable cerebral aspergillosis. J Clin Microbiol. 2002; 40 (4) 1496-1499
200 Miaux Y, Ribaud P, Williams M et al.. MR of cerebral aspergillosis in patients who have had bone marrow transplantation. AJNR Am J Neuroradiol. 1995; 16 (3) 555-562
201 Gabelmann A, Klein S, Kern W et al.. Relevant imaging findings of cerebral aspergillosis on MRI: a retrospective case-based study in immunocompromised patients. Eur J Neurol. 2007; 14 (5) 548-555
202 Hurst R W, Judkins A, Bolger W, Chu A, Loevner L A. Mycotic aneurysm and cerebral infarction resulting from fungal sinusitis: imaging and pathologic correlation. AJNR Am J Neuroradiol. 2001; 22 (5) 858-863
203 Endo T, Tominaga T, Konno H, Yoshimoto T. Fatal subarachnoid hemorrhage, with brainstem and cerebellar infarction, caused by Aspergillus infection after cerebral aneurysm surgery: case report. Neurosurgery. 2002; 50 (5) 1147-1150 discussion 1150-1151
204 Iihara K, Makita Y, Nabeshima S, Tei T, Keyaki A, Nioka H. Aspergillosis of the central nervous system causing subarachnoid hemorrhage from mycotic aneurysm of the basilar artery—case report. Neurol Med Chir (Tokyo). 1990; 30 (8) 618-623
205 Schwartz S, Ruhnke M, Ribaud P et al.. Improved outcome in central nervous system aspergillosis, using voriconazole treatment. Blood. 2005; 106 (8) 2641-2645
206 Radner A B, Witt M D, Edwards Jr J E. Acute invasive rhinocerebral zygomycosis in an otherwise healthy patient: case report and review. Clin Infect Dis. 1995; 20 (1) 163-166
207 Press G A, Weindling S M, Hesselink J R, Ochi J W, Harris J P. Rhinocerebral mucormycosis: MR manifestations. J Comput Assist Tomogr. 1988; 12 (5) 744-749
208 Calli C, Savas R, Parildar M, Pekindil G, Alper H, Yunten N. Isolated pontine infarction due to rhinocerebral mucormycosis. Neuroradiology. 1999; 41 (3) 179-181
209 Rangel-Guerra R A, Martínez H R, Sáenz C, Bosques-Padilla F, Estrada-Bellmann I. Rhinocerebral and systemic mucormycosis. Clinical experience with 36 cases. J Neurol Sci. 1996; 143 (1-2) 19-30
210 Pagano L, Ricci P, Tonso A et al.. Mucormycosis in patients with haematological malignancies: a retrospective clinical study of 37 cases. GIMEMA Infection Program (Gruppo Italiano Malattie Ematologiche Maligne dell'Adulto). Br J Haematol. 1997; 99 (2) 331-336
211 Escobar A, Del Brutto O H. Multiple brain abscesses from isolated cerebral mucormycosis. J Neurol Neurosurg Psychiatry. 1990; 53 (5) 431-433
212 Cuadrado L M, Guerrero A, Garcia Asenjo J A, Martin F, Palau E, Garcia Urra D. Cerebral mucormycosis in two cases of acquired immunodeficiency syndrome. Arch Neurol. 1988; 45 (1) 109-111
213 Hopkins R J, Rothman M, Fiore A, Goldblum S E. Cerebral mucormycosis associated with intravenous drug use: three case reports and review. Clin Infect Dis. 1994; 19 (6) 1133-1137
214 Zarei M, Morris J, Aachi V, Gregory R, Meanock C, Brito-Babapulle F. Acute isolated cerebral mucormycosis in a patient with high grade non-Hodgkins lymphoma. Eur J Neurol. 2000; 7 (4) 443-447
215 Yousem D M, Galetta S L, Gusnard D A, Goldberg H I. MR findings in rhinocerebral mucormycosis. J Comput Assist Tomogr. 1989; 13 (5) 878-882
216 Galetta S L, Wulc A E, Goldberg H I, Nichols C W, Glaser J S. Rhinocerebral mucormycosis: management and survival after carotid occlusion. Ann Neurol. 1990; 28 (1) 103-107
217 Lazo A, Wilner H I, Metes J J. Craniofacial mucormycosis: computed tomographic and angiographic findings in two cases. Radiology. 1981; 139 (3) 623-626
218 Mischel P S, Vinters H V. Coccidioidomycosis of the central nervous system: neuropathological and vasculopathic manifestations and clinical correlates. Clin Infect Dis. 1995; 20 (2) 400-405
219 Mathisen G, Shelub A, Truong J, Wigen C. Coccidioidal meningitis: clinical presentation and management in the fluconazole era. Medicine (Baltimore). 2010; 89 (5) 251-284
220 Sobel R A, Ellis W G, Nielsen S L, Davis R L. Central nervous system coccidioidomycosis: a clinicopathologic study of treatment with and without amphotericin B. Hum Pathol. 1984; 15 (10) 980-995
221 Mathisen G, Shelub A, Truong J, Wigen C. Coccidioidal meningitis: clinical presentation and management in the fluconazole era. Medicine (Baltimore). 2010; 89 (5) 251-284
222 Williams P L, Johnson R, Pappagianis D et al.. Vasculitic and encephalitic complications associated with Coccidioides immitis infection of the central nervous system in humans: report of 10 cases and review. Clin Infect Dis. 1992; 14 (3) 673-682
223 Arsura E L, Johnson R, Penrose J et al.. Neuroimaging as a guide to predict outcomes for patients with coccidioidal meningitis. Clin Infect Dis. 2005; 40 (4) 624-627
224 de Carvalho C A, Allen J N, Zafranis A, Yates A J. Coccidioidal meningitis complicated by cerebral arteritis and infarction. Hum Pathol. 1980; 11 (3) 293-296
225 Johnson R H, Einstein H E. Coccidioidal meningitis. Clin Infect Dis. 2006; 42 (1) 103-107
226 Drake K W, Adam R D. Coccidioidal meningitis and brain abscesses: analysis of 71 cases at a referral center. Neurology. 2009; 73 (21) 1780-1786
227 Ragland A S, Arsura E, Ismail Y, Johnson R. Eosinophilic pleocytosis in coccidioidal meningitis: frequency and significance. Am J Med. 1993; 95 (3) 254-257
228 Blair J E, Coakley B, Santelli A C, Hentz J G, Wengenack N L. Serologic testing for symptomatic coccidioidomycosis in immunocompetent and immunosuppressed hosts. Mycopathologia. 2006; 162 (5) 317-324
229 Williams P L. Vasculitic complications associated with coccidioidal meningitis. Semin Respir Infect. 2001; 16 (4) 270-279
230 Galgiani J N, Ampel N M, Blair J E Infectious Diseases Society of America et al. Coccidioidomycosis. Clin Infect Dis. 2005; 41 (9) 1217-1223
231 Cortez K J, Walsh T J, Bennett J E. Successful treatment of coccidioidal meningitis with voriconazole. Clin Infect Dis. 2003; 36 (12) 1619-1622
232 Wheat L J, Batteiger B E, Sathapatayavongs B. Histoplasma capsulatum infections of the central nervous system. A clinical review. Medicine (Baltimore). 1990; 69 (4) 244-260
233 Saccente M. Central nervous system histoplasmosis. Curr Treat Options Neurol. 2008; 10 (3) 161-167
234 Carod-Artal F J, Venturini M, Gomes E, de Mello M T. [Chronic central nervous system histoplasmosis in an immunocompetent patient]. Neurologia. 2008; 23 (4) 263-268
235 Wheat L J, Musial C E, Jenny-Avital E. Diagnosis and management of central nervous system histoplasmosis. Clin Infect Dis. 2005; 40 (6) 844-852
236 Mitchell D H, Sorrell T C, Allworth A M et al.. Cryptococcal disease of the CNS in immunocompetent hosts: influence of cryptococcal variety on clinical manifestations and outcome. Clin Infect Dis. 1995; 20 (3) 611-616
237 Shih C C, Chen Y C, Chang S C, Luh K T, Hsieh W C. Cryptococcal meningitis in non-HIV-infected patients. QJM. 2000; 93 (4) 245-251
238 Tjia T L, Yeow Y K, Tan C B. Cryptococcal meningitis. J Neurol Neurosurg Psychiatry. 1985; 48 (9) 853-858
239 Lan S H, Chang W N, Lu C H, Lui C C, Chang H W. Cerebral infarction in chronic meningitis: a comparison of tuberculous meningitis and cryptococcal meningitis. QJM. 2001; 94 (5) 247-253
240 Chen S, Sorrell T, Nimmo G Australasian Cryptococcal Study Group et al. Epidemiology and host- and variety-dependent characteristics of infection due to Cryptococcus neoformans in Australia and New Zealand. Clin Infect Dis. 2000; 31 (2) 499-508
241 Lane M, McBride J, Archer J. Steroid responsive late deterioration in Cryptococcus neoformans variety gattii meningitis. Neurology. 2004; 63 (4) 713-714
242 Saag M S, Graybill R J, Larsen R A Infectious Diseases Society of America et al. Practice guidelines for the management of cryptococcal disease. Clin Infect Dis. 2000; 30 (4) 710-718
243 Garcia H H, Gonzalez A E, Gilman R H. Cysticerosis Working Group in Peru . Diagnosis, treatment and control of Taenia solium cysticercosis. Curr Opin Infect Dis. 2003; 16 (5) 411-419
244 Alarcón F, Hidalgo F, Moncayo J, Viñán I, Dueñas G. Cerebral cysticercosis and stroke. Stroke. 1992; 23 (2) 224-228
245 Del Brutto O H. Cysticercosis and cerebrovascular disease: a review. J Neurol Neurosurg Psychiatry. 1992; 55 (4) 252-254
246 Scharf D. Neurocysticercosis. Two hundred thirty-eight cases from a California hospital. Arch Neurol. 1988; 45 (7) 777-780
247 Barinagarrementeria F, Cantú C. Frequency of cerebral arteritis in subarachnoid cysticercosis: an angiographic study. Stroke. 1998; 29 (1) 123-125
248 Alarcón F, Vanormelingen K, Moncayo J, Viñán I. Cerebral cysticercosis as a risk factor for stroke in young and middle-aged people. Stroke. 1992; 23 (11) 1563-1565
249 Del Brutto O, Barinagarrementeria F. Inflammatory arteriopathies and pure motor hemiplegia. Arch Neurol. 1989; 46 (4) 361
250 Rodriguez-Carbajal J, Del Brutto O H, Penagos P, Huebe J, Escobar A. Occlusion of the middle cerebral artery due to cysticercotic angiitis. Stroke. 1989; 20 (8) 1095-1099
251 Cantú C, Barinagarrementeria F. Cerebrovascular complications of neurocysticercosis. Clinical and neuroimaging spectrum. Arch Neurol. 1996; 53 (3) 233-239
252 Patel R, Jha S, Yadav R K. Pleomorphism of the clinical manifestations of neurocysticercosis. Trans R Soc Trop Med Hyg. 2006; 100 (2) 134-141
253 Bouldin A, Pinter J D. Resolution of arterial stenosis in a patient with periarterial neurocysticercosis treated with oral prednisone. J Child Neurol. 2006; 21 (12) 1064-1067
254 Cantú C, Villarreal J, Soto J L, Barinagarrementeria F. Cerebral cysticercotic arteritis: detection and follow-up by transcranial Doppler. Cerebrovasc Dis. 1998; 8 (1) 2-7
255 Viola G M, White Jr A C, Serpa J A. Hemorrhagic cerebrovascular events and neurocysticercosis: a case report and review of the literature. Am J Trop Med Hyg. 2011; 84 (3) 402-405
256 García H H, Evans C AW, Nash T E et al.. Current consensus guidelines for treatment of neurocysticercosis. Clin Microbiol Rev. 2002; 15 (4) 747-756

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