Clinical Assessment and Management of the Endometrium in Recurrent Early Pregnancy Loss

Bansari G. Patel; Bruce A. Lessey

doi:10.1055/s-0031-1293203

Seminars in Reproductive Medicine, Table of Contents

Semin Reprod Med 2011; 29(6): 491-506
DOI: 10.1055/s-0031-1293203

Clinical Assessment and Management of the Endometrium in Recurrent Early Pregnancy Loss

Bansari G. Patel¹ , Bruce A. Lessey²

¹Department of Obstetrics and Gynecology, Greenville, South Carolina
²University Medical Group, Greenville Hospital System, Greenville, South Carolina

Abstract

ABSTRACT

Unexplained and recurrent loss of pregnancies is a heartbreaking and frustrating condition. The routine diagnostic workup for pregnancy loss includes hormonal evaluation, screening for genetic or chromosomal defects, immunologic and thrombophilic testing, and evaluation of congenital or acquired Müllerian defects. In cases of idiopathic pregnancy loss, defects in endometrial receptivity are increasingly being investigated. The role of the endometrium in pregnancy loss has historical roots but remains controversial. Exciting new directions based on microRNAs, proteomics, and epigenetics promises to keep this area of investigation both interesting and complex. With each new diagnostic and therapeutic biomarker identified comes a greater potential for diagnosis and treatment of women. The clinical assessment of the endometrium remains an important part of the investigation of couples with unexplained pregnancy loss.

KEYWORDS

Miscarriage - endometrium - endometriosis - luteal phase defect - hydrosalpinges - pregnancy loss

Full Text

References

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Bruce A. LesseyM.D. Ph.D.

Department of Obstetrics and Gynecology, University Medical Group, Greenville Hospital System

890 W. Faris Rd., Suite 470, Greenville, SC 29605

Email: blessey@ghs.org