Synthesis and determination of acute and chronic pain activities of 1-[1-(3-methylphenyl) (tetralyl)]piperidine as a new derivative of phencyclidine via tail immersion and formalin tests

Abbas Ahmadi; Mohsen Khalili; Farnaz Mihandoust; Leila Barghi

doi:10.1055/s-0031-1296245

Arzneimittelforschung, Inhaltsverzeichnis

Arzneimittelforschung 2010; 60(1): 30-35
DOI: 10.1055/s-0031-1296245

CNS-active Drugs · Hypnotics · Psychotropics · Sedatives

Editio Cantor Verlag Aulendorf (Germany)

Synthesis and determination of acute and chronic pain activities of 1-[1-(3-methylphenyl) (tetralyl)]piperidine as a new derivative of phencyclidine via tail immersion and formalin tests

Abbas Ahmadi

¹Department of Chemistry, Faculty of Sciences, Islamic Azad University, Karaj Branch, Karaj, Iran

,

Mohsen Khalili

²Department of Physiology, Shahed University, Tehran, Iran

,

Farnaz Mihandoust

¹Department of Chemistry, Faculty of Sciences, Islamic Azad University, Karaj Branch, Karaj, Iran

,

Leila Barghi

¹Department of Chemistry, Faculty of Sciences, Islamic Azad University, Karaj Branch, Karaj, Iran

› Institutsangaben

Abstract

Phencyclidine (1-(1-phenylcyclohexyl)piperidine, CAS 956-90-1, PCP, I) and ketamine (2-O-chlorophenyl-2-methylamino-cyclohexan, CAS 1867-66-9, II) revealed some analgesic effects. Some of their derivatives have been synthesized for biological properties studies. Utilizing 1-tetralone as a starting material, 1-[1-(3-methylphenyl)(tetralyl)]piperidine, (PCP-CH₃-tetralyl, III) was synthesized and its analgesic effects were studied on rats via tail immersion (as a model of acute thermal pain) and formalin (as a model of acute chemical and chronic pain) tests and compared with those of ketamine and PCP. The results indicated a marked anti-nociception 2-25 min after ketamine injection, but this analgesic effect lasted for 40 min following PCP-CH₃-tetralyl application in the tail immersion test. However, the data obtained from the formalin test showed that chronic pain could be significantly attenuated by ketamine, PCP and PCP-CH₃-tetralyl.

Key words

CAS 956-90-1 - CAS 1867-66-9 - Ketamine - Phencyclidine - 1-Tetralone derivatives, analgesic effects, formalin test, tail immersion test

Volltext

Referenzen

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