Ultraschall Med 2012; 33(7): E88-E94
DOI: 10.1055/s-0031-1299483
Original Article
© Georg Thieme Verlag KG Stuttgart · New York

Pixelwise Quantification of Placental Perfusion Visualized by 3D Power Doppler Sonography

Pixelweise Plazentaperfusionsmessung aus dreidimensionalen Power-Doppler-Daten
T. M. Scholbach
1   Klinik für Kinder- und Jugendmedizin, Klinikum Chemnitz
,
J. Konje
2   Obstetrics and Gynaecology, Leicester Royal Infirmary
,
B. Huppertz
3   Medical University of Graz, Institute of Cell Biology, Histology and Embryology
› Author Affiliations
Further Information

Publication History

01 December 2011

12 March 2012

Publication Date:
10 May 2012 (online)

Abstract

Purpose: We present a new method for noninvasive automatic measurement of perfusion intensity (PixelFlux method) in standardized 3 D power Doppler sonography to quantify differences of perfusion intensities among different placental layers.

Materials and Methods: Power Doppler sonographic videos of anterior and central placentas were recorded at various gestational ages (13 to 38 weeks) under defined conditions in 22 women with uncomplicated pregnancies which ended in the delivery of an appropriately grown fetus. Tissue perfusion intensity in four placental layers was calculated as the product of the Doppler amplitude and the perfused area encoded by power Doppler signals related to the area of the respective layer. Measurements are given as the percentage of maximal possible perfusion.

Results: Significant differences in placental perfusion intensities in the uterine wall (6.6 %), the maternal flow within the intervillous space (2.4 %), the fetal flow within placental villi (1.6 %) and the chorionic plate (9.3 %) were demonstrated with a continuous increase in the uterine wall and the placental villi.

Conclusion: Placental perfusion intensity was quantified noninvasively from 3 D power Doppler signal data in an easily accomplishable manner with a new software-based measurement procedure. There are significant differences in perfusion intensities among placental layers. Placenta perfusion measurement with the PixelFlux method is feasible and can discern significant perfusion differences among different placenta layers.

Zusammenfassung

Ziel: Wir stellen eine neue, nicht invasive Methode vor, die eine pixelweise Bemessung der Perfusion verschiedener Plazentaschichten aus standardisierten dreidimensionalen Powerdoppler-Videos ermöglicht (PixelFlux-Methode).

Material und Methoden: Standardisierte Powerdoppler-Videos anterior und zentral lokalisierter Plazenten (13.–38. Schwangerschaftswoche) von 22 Schwangeren wurden unter definierten Bedingungen untersucht. Alle Schwangerschaften führten zur Geburt eines normalgewichtigen Kindes. Die Gewebsperfusionsintensität in 4 Plazentaschichten wurde mithilfe der PixelFlux-Software als Produkt der Amplitude der Powerdoppler-Signale und der perfundierten Fläche bezogen auf die Fläche der Untersuchungsregion automatisch berechnet. Die Perfusionsintensität wurde in Prozent der maximal möglichen Perfusion angegeben.

Ergebnisse: Zwischen der Uteruswand (6,6 %), der maternalen (2,4 %), der fetalen Schicht (1,6 %) und der Chorionplatte (9,3 %) konnten signifikante Perfusionsintensitätsunterschiede nachgewiesen werden. Im Verlauf der Schwangerschaft kam es zu einem kontinuierlichen Anstieg der Perfusionsintensität in der Uteruswand und den Plazentazotten.

Schlussfolgerung: Die PixelFlux-Methode erlaubt die Messung der Plazentaperfusion aus dreidimensionalen Powerdoppler-Ultraschallvideos und kann Unterschiede der Perfusion der Plazentaschichten darstellen.

 
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