Intervention of TLR4 Signal Pathway Cytokines in Severe Liver Injury with Obstructive Jaundice in Rats

L. Lin; W. M. Cai; C. J. Qin; L. C. Miao; L. T. Yun; Y. Hua; L. Weilin

doi:10.1055/s-0031-1301318

International Journal of Sports Medicine, Table of Contents

Int J Sports Med 2012; 33(07): 572-579
DOI: 10.1055/s-0031-1301318

Clinical Sciences

Intervention of TLR4 Signal Pathway Cytokines in Severe Liver Injury with Obstructive Jaundice in Rats

Authors

L. Lin

¹Hunan Normal University, College of Physical Education, Changsha, China
W. M. Cai

¹Hunan Normal University, College of Physical Education, Changsha, China
C. J. Qin

¹Hunan Normal University, College of Physical Education, Changsha, China
L. C. Miao

²Central Hospital of Shaoyang, Shaoyang, China
L. T. Yun

²Central Hospital of Shaoyang, Shaoyang, China
Y. Hua

²Central Hospital of Shaoyang, Shaoyang, China
L. Weilin

¹Hunan Normal University, College of Physical Education, Changsha, China

Abstract

Obstructive jaundice is a common surgical disease and a variety of end-stage severe liver injuries still lack effective treatments. Compared to traditional liver transplantation therapy, herbal treatment is noninvasive and has fewer side effects. Research results have shown that a modified major decoction of bupleurum can reduce the toxic reaction of obstructive jaundice, even though the mechanism is unclear. A period of chronic exercise training can significantly reduce TLR4 expression in mononuclear cells and the secretion of inflammatory cell factors. Our study administered a modified major decoction of bupleurum in combination with exercise in rats with obstructive jaundice and the results indicated that applying a major bupleurum decoction in combination with moderately intense aerobic exercise showed a beneficial effect on adjusting the expression of liver inflammatory cytokines, which thus improved immunity and finally reduced the liver injury of rats with obstructive jaundice.

Key words

modified major decoction of bupleurum - medium-intensity aerobic exercise - obstructive jaundice - TLR4

Full Text

References

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