Experimental and Clinical Endocrinology & Diabetes, Table of Contents Exp Clin Endocrinol Diabetes 2012; 120(04): 184-185DOI: 10.1055/s-0032-1304566 Mini-Review Series on Diabetes and its Complications © J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New YorkDrosophila: A Model for Understanding Obesity and Diabetic Complications Authors Author Affiliations A. A. Teleman 1 German Cancer Research Center (DKFZ), Heidelberg, Germany I. Ratzenböck 2 Department of Medicine I and Clinical Chemistry, University of Heidelberg, Heidelberg, Germany S. Oldham 3 Sanford – Burnham Medical Research Institute, La Jolla, CA, USA Recommend Article Abstract Buy Article(opens in new window) Abstract The molecular mechanisms underlying development of obesity and diabetic complications are not well understood. Drosophila has become a popular model organism for studying a variety of human diseases. We discuss here emerging Drosophila models of obesity and diabetic complications. Key words Key wordsneuropathy - obesity - signal transduction Full Text References References 1 Lachin JM, Genuth S, Nathan DM et al. Effect of glycemic exposure on the risk of microvascular complications in the diabetes control and complications trial – revisited. Diabetes 2008; 57: 995-1001 2 Lessing D, Bonini NM. Maintaining the brain: insight into human neurodegeneration from Drosophila melanogaster mutants. Nat Rev Genet 2009; 10: 359-370 3 Wessells RJ, Fitzgerald E, Cypser JR et al. Insulin regulation of heart function in aging fruit flies. Nat Genet 2004; 36: 1275-1281 4 Birse RT, Choi J, Reardon K et al. High-fat-diet-induced obesity and heart dysfunction are regulated by the TOR pathway in Drosophila. Cell metabolism 2010; 12: 533-544 5 Musselman LP, Fink JL, Narzinski K et al. A high-sugar diet produces obesity and insulin resistance in wild-type Drosophila. Dis Model Mech 2011; 4: 842-849 6 Murillo-Maldonado JM, Sanchez-Chavez G, Salgado LM et al. Drosophila insulin pathway mutants affect visual physiology and brain function besides growth, lipid, and carbohydrate metabolism. Diabetes 2011; 60: 1632-1636 7 Wang T, Lao U, Edgar BA. TOR-mediated autophagy regulates cell death in Drosophila neurodegenerative disease. The Journal of cell biology 2009; 186: 703-711
