Abstract
In this study, the pharmacokinetics of 2 forms of mirodenafil, namely the base form
and the hydrochloride salt form, were investigated in rats. The 2 forms were orally
administered to rats and the plasma concentrations of mirodenafil were determined
using liquid chromatography-tandem mass spectrometry (LC-MS/MS). The mirodenafil base
and hydrochloride salt forms showed similar pharmacokinetic profiles in terms of their
maximum plasma concentration (Cmax ) and area under the concentration-time curve (AUC). The time to peak concentration
(Tmax ) of the base form was slightly greater than that of the salt form, but this difference
was not statistically significant. These results suggest that the mirodenafil base
and hydrochloride forms are pharmacokinetically equivalent in rats, and thus the base
form could be used in various mirodenafil formulations as a substitute for the existing
mirodenafil hydrochloride form.
Key words mirodenafil - comparative pharmacokinetics - rats - LC-MS/MS
