Improvement of Hyperphagia by Activation of Cerebral I1-Imidazoline Receptors in Streptozotocin-induced Diabetic Mice

H. H. Chung; T. T. Yang; M. F. Chen; M. T. Chou; J. T. Cheng

doi:10.1055/s-0032-1314835

Hormone and Metabolic Research, Table of Contents

Horm Metab Res 2012; 44(09): 645-649
DOI: 10.1055/s-0032-1314835

Original Basic

Improvement of Hyperphagia by Activation of Cerebral I₁-Imidazoline Receptors in Streptozotocin-induced Diabetic Mice

Authors

H. H. Chung

¹Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan City, Taiwan
T. T. Yang

²Department of Pathology, School of Chinese Medicine for Post-Baccalaureate, I-Shou University, Kaohsiung City, Taiwan
M. F. Chen

³Department of Nursing and Biotechnology, Chung Hwa University of Medical Technology, Jen-Te, Tainan City, Taiwan
M. T. Chou

⁴Department of Cardiology and Department of Medical Research, Chi-Mei Medical Center, Yong Kang, Tainan City, Taiwan
J. T. Cheng

¹Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan City, Taiwan

⁴Department of Cardiology and Department of Medical Research, Chi-Mei Medical Center, Yong Kang, Tainan City, Taiwan

⁵Institute of Medical Science, College of Health Science, Chang Jung Christian University, Guei-Ren, Tainan City, Taiwan

Abstract

Imidazoline I₁-receptors (I₁R) are known to regulate blood pressure and rilmenidine, an agonist, is widely used as antihypertensive agent in clinic. However, the role of I₁R in feeding behavior is still unclear. In the present study, we used the agonist of I₁R to investigate the effect on hyperphagia in streptozotocin (STZ)-induced diabetic mice. Rilmenidine decreased the food intake of STZ-diabetic mice in a dose-dependent manner. The reduction of food intake was abolished by pretreatment with efaroxan at the dose sufficient to block I₁R. Intracerebroventricular (icv) administration of rilmenidine into STZ-diabetic mice also significantly reduced hyperphagia, which was reversed by icv administration of efaroxan. In addition, similar results were observed in STZ-diabetic mice, which received chronic treatment with rilmenidine 3 times daily (t.i.d.) for 7 days. Moreover, the hypothalamic neuropeptide Y (NPY) level was reduced by rilmenidine that was also reversed by pretreatment with efaroxan. In conclusion, the obtained results suggest that rilmenidine can decrease food intake in STZ-diabetic mice through an activation of I₁R to lower hypothalamic NPY level.

Key words

feeding - hyperphagia - imidazoline I₁-receptors - neuropeptide Y - STZ-diabetic mice

Full Text

References

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