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Int J Sports Med 2013; 34(03): 253-257
DOI: 10.1055/s-0032-1316317
Clinical Sciences
© Georg Thieme Verlag KG Stuttgart · New York

The Effects of Aerobic Training and Age on Plasma sICAM-1

G. M. Many
1   Children’s National Medical Center, Research Center for Genetic Medicine, Washington DC, United States
,
N. T. Jenkins
2   Department of Biomedical Sciences, University of Missouri, Columbia, United States
,
S. Witkowski
3   Department of Kinesiology, University of Massachusetts, Amherst, United States
,
J. M. Damsker
1   Children’s National Medical Center, Research Center for Genetic Medicine, Washington DC, United States
,
J. Hagberg
4   Department of Kinesiology, University of Maryland, College Park, United States
› Author Affiliations
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Publication History



accepted after revision 07 May 2012

Publication Date:
12 September 2012 (online)

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Abstract

Chronic low-grade systemic inflammation plays a role in the development of cardiovascular (CV) disease. Habitual endurance exercise training reduces the risk of CV disease in part through anti-inflammatory mechanisms. The purpose of this study was to investigate the effects of age, endurance training status, and their interaction on pro-inflammatory plasma cytokines involved in the pathogenesis of CV disease. Subjects were BMI-matched young (25±3 years; endurance trained: n=9, sedentary: n=11) and older (62±5 years; endurance-trained: n=12, sedentary: n=11) men. Plasma cytokine concentrations were determined by multiplex cytometric bead assay. Soluble intercellular adhesion molecule-1 (sICAM-1) levels were 40% higher in sedentary older men compared to young sedentary subjects (P=0.048), but they were not different between the young and older trained men. Furthermore, sICAM-1 levels were negatively correlated with maximal oxygen uptake (V˙O2max; r= − 0.38, P=0.01) across all subjects. There were no significant differences among the groups in plasma concentrations of monocyte chemoattractant protein-1 (MCP-1), soluble tumor necrosis-α receptor (sTNFR), soluble CD40 ligand (sCD40L), or resistin. We conclude that habitual endurance training is associated with an attenuated age-related increase in plasma sICAM-1.

Key words

systemic inflammation - age - endurance training - physical inactivity - adhesion molecules
 

  • References

  • 1 Adamopoulos S, Parissis J, Kroupis C, Georgiadis M, Karatzas D, Karavolias G, Koniavitou K, Coats AJ, Kremastinos DT. Physical training reduces peripheral markers of inflammation in patients with chronic heart failure. Eur Heart J 2001; 22: 791-797
    CrossrefPubMedGoogle Scholar
  • 2 Blair SN, Kohl 3rd  HW, Paffenbarger Jr RS, Clark DG, Cooper KH, Gibbons LW. Physical fitness and all-cause mortality. A prospective study of healthy men and women. JAMA 1989; 262: 2395-2401
    CrossrefPubMedGoogle Scholar
  • 3 Brake DK, Smith EO, Mersmann H, Smith CW, Robker RL. Icam-1 expression in adipose tissue: Effects of diet-induced obesity in mice. Am J Physiol
    PubMedGoogle Scholar
  • 4 Bruunsgaard H. Physical activity and modulation of systemic low-level inflammation. J Leukoc Biol 2005; 78: 819-835
    CrossrefPubMedGoogle Scholar
  • 5 Febbraio MA, Pedersen BK. Contraction-induced myokine production and release: Is skeletal muscle an endocrine organ?. Exerc Sport Sci Rev 2005; 33: 114-119
    CrossrefPubMedGoogle Scholar
  • 6 Fischer CP, Berntsen A, Perstrup LB, Eskildsen P, Pedersen BK. Plasma levels of interleukin-6 and c-reactive protein are associated with physical inactivity independent of obesity. Scand J Med Sci Sports 2007; 17: 580-587
    PubMedGoogle Scholar
  • 7 Franceschi C, Capri M, Monti D, Giunta S, Olivieri F, Sevini F, Panourgia MP, Invidia L, Celani L, Scurti M, Cevenini E, Castellani GC, Salvioli S. Inflammaging and anti-inflammaging: A systemic perspective on aging and longevity emerged from studies in humans. Mech Ageing Dev 2007; 128: 92-105
    CrossrefPubMedGoogle Scholar
  • 8 Hamdy O, Ledbury S, Mullooly C, Jarema C, Porter S, Ovalle K, Moussa A, Caselli A, Caballero AE, Economides PA, Veves A, Horton ES. Lifestyle modification improves endothelial function in obese subjects with the insulin resistance syndrome. Diabetes Care 2003; 26: 2119-2125
    CrossrefPubMedGoogle Scholar
  • 9 Harriss DJ, Atkinson G. Update – ethical standards in sport and exercise science research. Int J Sports Med 2011; 32: 819-821
    Article in Thieme ConnectPubMedGoogle Scholar
  • 10 Hulthe J, Wikstrand J, Mattsson-Hulten L, Fagerberg B. Circulating icam-1 (intercellular cell-adhesion molecule 1) is associated with early stages of atherosclerosis development and with inflammatory cytokines in healthy 58-year-old men: The atherosclerosis and insulin resistance (air) study. Clin Sci (Lond) 2002; 103: 123-129
    CrossrefPubMedGoogle Scholar
  • 11 Ito H, Ohshima A, Inoue M, Ohto N, Nakasuga K, Kaji Y, Maruyama T, Nishioka K. Weight reduction decreases soluble cellular adhesion molecules in obese women. Clin Exp Pharmacol Physiol 2002; 29: 399-404
    CrossrefPubMedGoogle Scholar
  • 12 Jackson AS, Pollock ML. Generalized equations for predicting body density of men. Br J Nutr 1978; 40: 497-504
    CrossrefPubMedGoogle Scholar
  • 13 Jenkins NT, Landers RQ, Prior SJ, Soni N, Spangenburg EE, Hagberg JM. Effects of acute and chronic endurance exercise on intracellular nitric oxide and superoxide in cd34+ and cd34- cells. J Appl Physiol 2011; 111: 929-937
    CrossrefPubMedGoogle Scholar
  • 14 Jenkins NT, Landers RQ, Thakkar SR, Fan X, Brown MD, Prior SJ, Spangenburg EE, Hagberg JM. Prior endurance exercise prevents postprandial lipaemia-induced increases in reactive oxygen species in circulating cd31+ cells. J Physiol 2011; 589: 5539-5553
    CrossrefPubMedGoogle Scholar
  • 15 Jenkins NT, McKenzie JA, Hagberg JM, Witkowski S. Plasma fetuin-a concentrations in young and older high- and low-active men. Metabolism 2011; 60: 265-271
    CrossrefPubMedGoogle Scholar
  • 16 Jenkins NT, Witkowski S, Spangenburg EE, Hagberg JM. Effects of acute and chronic endurance exercise on intracellular nitric oxide in putative endothelial progenitor cells: Role of napdh oxidase. Am J Physiol
    PubMedGoogle Scholar
  • 17 Kawanishi N, Yano H, Yokogawa Y, Suzuki K. Exercise training inhibits inflammation in adipose tissue via both suppression of macrophage infiltration and acceleration of phenotypic switching from m1 to m2 macrophages in high-fat-diet-induced obese mice. Exerc Immunol Rev 2010; 16: 105-118
    PubMedGoogle Scholar
  • 18 Kim HO, Kim HS, Youn JC, Shin EC, Park S. Serum cytokine profiles in healthy young and elderly population assessed using multiplexed bead-based immunoassays. J Transl Med 2011; 9: 113
    CrossrefPubMedGoogle Scholar
  • 19 Libby P, Ridker PM, Hansson GK. Progress and challenges in translating the biology of atherosclerosis. Nature 2011; 473: 317-325
    CrossrefPubMedGoogle Scholar
  • 20 Mallika V, Goswami B, Rajappa M. Atherosclerosis pathophysiology and the role of novel risk factors: A clinicobiochemical perspective. Angiology 2007; 58: 513-522
    CrossrefPubMedGoogle Scholar
  • 21 Mendoza-Nunez VM, Rosado-Perez J, Santiago-Osorio E, Ortiz R, Sanchez-Rodriguez MA, Galvan-Duarte RE. Aging linked to type 2 diabetes increases oxidative stress and chronic inflammation. Rejuvenation Res 2011; 14: 25-31
    CrossrefPubMedGoogle Scholar
  • 22 Miles EA, Thies F, Wallace FA, Powell JR, Hurst TL, Newsholme EA, Calder PC. Influence of age and dietary fish oil on plasma soluble adhesion molecule concentrations. Clin Sci (Lond) 2001; 100: 91-100
    CrossrefPubMedGoogle Scholar
  • 23 Mora S, Cook N, Buring JE, Ridker PM, Lee IM. Physical activity and reduced risk of cardiovascular events: Potential mediating mechanisms. Circulation 2007; 116: 2110-2118
    CrossrefPubMedGoogle Scholar
  • 24 Niebauer J, Clark AL, Webb-Peploe KM, Coats AJ. Exercise training in chronic heart failure: Effects on pro-inflammatory markers. Eur J Heart Fail 2005; 7: 189-193
    CrossrefPubMedGoogle Scholar
  • 25 Pedersen BK. The diseasome of physical inactivity – and the role of myokines in muscle-fat cross talk. J Physiol 2009; 587: 5559-5568
    CrossrefPubMedGoogle Scholar
  • 26 Rector RS, Turk JR, Sun GY, Guilford BL, Toedebusch BW, McClanahan MW, Thomas TR. Short-term lifestyle modification alters circulating biomarkers of endothelial health in sedentary, overweight adults. Appl Physiol Nutr Metab 2006; 31: 512-517
    CrossrefPubMedGoogle Scholar
  • 27 Rohde LE, Hennekens CH, Ridker PM. Cross-sectional study of soluble intercellular adhesion molecule-1 and cardiovascular risk factors in apparently healthy men. Arterioscler Thromb Vasc Biol 1999; 19: 1595-1599
    CrossrefPubMedGoogle Scholar
  • 28 Sultan S, Gosling M, Nagase H, Powell JT. Shear stress-induced shedding of soluble intercellular adhesion molecule-1 from saphenous vein endothelium. FEBS Lett 2004; 564: 161-165
    CrossrefPubMedGoogle Scholar
  • 29 Szekanecz Z, Shah MR, Pearce WH, Koch AE. Intercellular adhesion molecule-1 (icam-1) expression and soluble icam-1 (sicam-1) production by cytokine-activated human aortic endothelial cells: A possible role for icam-1 and sicam-1 in atherosclerotic aortic aneurysms. Clin Exp Immunol 1994; 98: 337-343
    PubMedGoogle Scholar
  • 30 van Bussel BC, Schouten F, Henry RM, Schalkwijk CG, de Boer MR, Ferreira I, Smulders YM, Twisk JW, Stehouwer CD. Endothelial dysfunction and low-grade inflammation are associated with greater arterial stiffness over a 6-year period. Hypertension 2011; 58: 588-595
    CrossrefPubMedGoogle Scholar
  • 31 Weyer C, Yudkin JS, Stehouwer CD, Schalkwijk CG, Pratley RE, Tataranni PA. Humoral markers of inflammation and endothelial dysfunction in relation to adiposity and in vivo insulin action in Pima Indians. Atherosclerosis 2002; 161: 233-242
    CrossrefPubMedGoogle Scholar
  • 32 Witkowski S, Lockard MM, Jenkins NT, Obisesan TO, Spangenburg EE, Hagberg JM. Relationship between circulating progenitor cells, vascular function and oxidative stress with long-term training and short-term detraining in older men. Clin Sci (Lond) 2010; 118: 303-311
    CrossrefPubMedGoogle Scholar
  • 33 Zhang L, Ebenezer PJ, Dasuri K, Fernandez-Kim SO, Francis J, Mariappan N, Gao Z, Ye J, Bruce-Keller AJ, Keller JN. Aging is associated with hypoxia and oxidative stress in adipose tissue: Implications for adipose function. Am J Physiol 2011; 301: E599-E607
    PubMedGoogle Scholar