Semin Neurol 2012; 32(02): 154-160
DOI: 10.1055/s-0032-1322588
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Infectious Etiologies of Myelopathy

Emily L. Ho
1   Department of Neurology, University of Washington, Harborview Medical Center, Seattle, Wahington
› Author Affiliations
Further Information

Publication History

Publication Date:
08 September 2012 (online)

Abstract

Myelopathy refers to a spinal cord disorder that presents with motor and/or sensory deficits. Infectious agents that cause myelopathy do so by either direct infection of neural structures (e.g., polio), a parainfectious mechanism (with a presumed autoimmune pathogenesis), or as a result of involvement of structures adjoining the spinal cord, which may cause a compressive myelopathy. This review of infectious causes of myelopathy focuses on pathogens that are most relevant to clinicians in North America.

 
  • References

  • 1 World Health Organization. Global Polio Eradication Initiative. Available at: http://www.polioeradication.org/Dataandmonitoring/Poliothisweek.aspx . Accessed June 18, 2012
  • 2 Centers for Disease Control and Prevention (CDC). Progress toward interruption of wild poliovirus transmission - worldwide, January 2011–March 2012. MMWR Morb Mortal Wkly Rep 2012; 61 (19) 353-357
  • 3 Roberts L. Infectious disease. Polio outbreak breaks the rules. Science 2010; 330 (6012) 1730-1731
  • 4 Kim-Farley RJ, Bart KJ, Schonberger LB , et al. Poliomyelitis in the USA: virtual elimination of disease caused by wild virus. Lancet 1984; 2 (8415) 1315-1317
  • 5 Centers for Disease Control and Prevention (CDC). Polio Disease - Questions and Answers. Available at: http://www.cdc.gov/vaccines/vpd-vac/polio/dis-faqs.htm . Accessed June 18, 2012
  • 6 Malzberg MS, Rogg JM, Tate CA, Zayas V, Easton JD. Poliomyelitis: hyperintensity of the anterior horn cells on MR images of the spinal cord. AJR Am J Roentgenol 1993; 161 (4) 863-865
  • 7 Chen CY, Chang YC, Huang CC, Lui CC, Lee KW, Huang SC. Acute flaccid paralysis in infants and young children with enterovirus 71 infection: MR imaging findings and clinical correlates. AJNR Am J Neuroradiol 2001; 22 (1) 200-205
  • 8 Cho HK, Lee NY, Lee H , et al. Enterovirus 71-associated hand, foot and mouth diseases with neurologic symptoms, a university hospital experience in Korea, 2009. Korean J Pediatr 2010; 53 (5) 639-643
  • 9 Liao HT, Hung KL. Neurologic involvement in an outbreak of enterovirus 71 infection: a hospital-based study. Acta Paediatr Taiwan 2001; 42 (1) 27-32
  • 10 Huang CC, Liu CC, Chang YC, Chen CY, Wang ST, Yeh TF. Neurologic complications in children with enterovirus 71 infection. N Engl J Med 1999; 341 (13) 936-942
  • 11 Gilbert GL, Dickson KE, Waters MJ, Kennett ML, Land SA, Sneddon M. Outbreak of enterovirus 71 infection in Victoria, Australia, with a high incidence of neurologic involvement. Pediatr Infect Dis J 1988; 7 (7) 484-488
  • 12 Shindarov LM, Chumakov MP, Voroshilova MK , et al. Epidemiological, clinical, and pathomorphological characteristics of epidemic poliomyelitis-like disease caused by enterovirus 71. J Hyg Epidemiol Microbiol Immunol 1979; 23 (3) 284-295
  • 13 Takimoto S, Waldman EA, Moreira RC , et al. Enterovirus 71 infection and acute neurological disease among children in Brazil (1988-1990). Trans R Soc Trop Med Hyg 1998; 92 (1) 25-28
  • 14 Centers for Disease Control and Prevention (CDC). Final 2010 West Nile virus Human Infections in the United States. Available at: http://www.cdc.gov/ncidod/dvbid/westnile/surv&controlCaseCount10_detailed.htm . Accessed June 18, 2012
  • 15 Petersen LR, Carson PJ, Biggerstaff BJ, Custer B, Borchardt SM, Busch MP. Estimated cumulative incidence of West Nile virus infection in US adults, 1999-2010. Epidemiol Infect 2012; 28: 1-5
  • 16 Flaherty ML, Wijdicks EF, Stevens JC , et al. Clinical and electrophysiologic patterns of flaccid paralysis due to West Nile virus. Mayo Clin Proc 2003; 78 (10) 1245-1248
  • 17 Sejvar JJ, Haddad MB, Tierney BC , et al. Neurologic manifestations and outcome of West Nile virus infection. JAMA 2003; 290 (4) 511-515
  • 18 Kraushaar G, Patel R, Stoneham GW. West Nile virus: a case report with flaccid paralysis and cervical spinal cord: MR imaging findings. AJNR Am J Neuroradiol 2005; 26 (1) 26-29
  • 19 Solomon T, Ravi V. Acute flaccid paralysis caused by West Nile virus. Lancet Infect Dis 2003; 3 (4) 189 , discussion 189–190
  • 20 Doron SI, Dashe JF, Adelman LS, Brown WF, Werner BG, Hadley S. Histopathologically proven poliomyelitis with quadriplegia and loss of brainstem function due to West Nile virus infection. Clin Infect Dis 2003; 37 (5) e74-e77
  • 21 Karacostas D, Christodoulou C, Drevelengas A , et al. Cytomegalovirus-associated transverse myelitis in a non-immunocompromised patient. Spinal Cord 2002; 40 (3) 145-149
  • 22 Majid A, Galetta SL, Sweeney CJ , et al. Epstein-Barr virus myeloradiculitis and encephalomyeloradiculitis. Brain 2002; 125 (Pt 1) 159-165
  • 23 Corral I, Quereda C, Navas E, Pérez-Elias MJ, Jover F, Moreno S. Sacral myeloradiculitis complicating genital herpes in a HIV-infected patient. Int J STD AIDS 2005; 16 (2) 175-177
  • 24 Tyler KL, Gross RA, Cascino GD. Unusual viral causes of transverse myelitis: hepatitis A virus and cytomegalovirus. Neurology 1986; 36 (6) 855-858
  • 25 Giobbia M, Carniato A, Scotton PG, Marchiori GC, Vaglia A. Cytomegalovirus-associated transverse myelitis in a non-immunocompromised patient. Infection 1999; 27 (3) 228-230
  • 26 Moudgil SS. Teaching neuroimages: herpes zoster myelitis. Neurology 2010; 75 (13) e55
  • 27 Derkinderen P, Bruneel F, Bouchaud O, Regnier B. Spondylodiscitis and epidural abscess due to Candida albicans. Eur Spine J 2000; 9 (1) 72-74
  • 28 Liang JD, Fang CT, Chen YC, Chang SC, Luh KT. Candida albicans spinal epidural abscess secondary to prosthetic valve endocarditis. Diagn Microbiol Infect Dis 2001; 40 (3) 121-123
  • 29 Garbino J, Schnyder I, Lew D, Bouchuiguir-Wafa K, Rohner P. An unusual cause of vertebral osteomyelitis: Candida species. Scand J Infect Dis 2003; 35 (4) 288-291
  • 30 Metcalfe S, Morgan-Hough C. Cervical epidural abscess and vertebral osteomyelitis following non-traumatic oesophageal rupture: a case report and discussion. Eur Spine J 2009; 18 (Suppl. 02) 224-227
  • 31 Dailey NJ, Young EJ. Candida glabrata spinal osteomyelitis. Am J Med Sci 2011; 341 (1) 78-82
  • 32 Gupta PK, Mahapatra AK, Gaind R, Bhandari S, Musa MM, Lad SD. Aspergillus spinal epidural abscess. Pediatr Neurosurg 2001; 35 (1) 18-23
  • 33 Auletta JJ, John CC. Spinal epidural abscesses in children: a 15-year experience and review of the literature. Clin Infect Dis 2001; 32 (1) 9-16
  • 34 Chi CY, Fung CP, Liu CY. Aspergillus flavus epidural abscess and osteomyelitis in a diabetic patient. J Microbiol Immunol Infect 2003; 36 (2) 145-148
  • 35 Saigal G, Donovan Post MJ, Kozic D. Thoracic intradural aspergillus abscess formation following epidural steroid injection. AJNR Am J Neuroradiol 2004; 25 (4) 642-644
  • 36 Tew CW, Han FC, Jureen R, Tey BH. Aspergillus vertebral osteomyelitis and epidural abscess. Singapore Med J 2009; 50 (4) e151-e154
  • 37 Bariola JR, Perry P, Pappas PG , et al. Blastomycosis of the central nervous system: a multicenter review of diagnosis and treatment in the modern era. Clin Infect Dis 2010; 50 (6) 797-804
  • 38 Pai M, Flores LL, Pai N, Hubbard A, Riley LW, Colford Jr JM. Diagnostic accuracy of nucleic acid amplification tests for tuberculous meningitis: a systematic review and meta-analysis. Lancet Infect Dis 2003; 3 (10) 633-643
  • 39 Kim SH, Cho OH, Park SJ , et al. Rapid diagnosis of tuberculous meningitis by T cell-based assays on peripheral blood and cerebrospinal fluid mononuclear cells. Clin Infect Dis 2010; 50 (10) 1349-1358
  • 40 Patel VB, Singh R, Connolly C , et al. Cerebrospinal T-cell responses aid in the diagnosis of tuberculous meningitis in a human immunodeficiency virus- and tuberculosis-endemic population. Am J Respir Crit Care Med 2010; 182 (4) 569-577
  • 41 Nussbaum ES, Rockswold GL, Bergman TA, Erickson DL, Seljeskog EL. Spinal tuberculosis: a diagnostic and management challenge. J Neurosurg 1995; 83 (2) 243-247
  • 42 Kim BJ, Park MH, Koh SB, Park MK, Park KW, Lee DH. Polyradiculomyelitis associated with clinically diagnosed tuberculous meningitis. Eur Neurol 2001; 46 (3) 156-157
  • 43 Schon F, Bowler JV. Syringomyelia and syringobulbia following tuberculous meningitis. J Neurol 1990; 237 (2) 122-123
  • 44 Fehlings MG, Bernstein M. Syringomyelia as a complication of tuberculous meningitis. Can J Neurol Sci 1992; 19 (1) 84-87
  • 45 Moon MS, Ha KY, Sun DH, Moon JL, Moon YW, Chung JH. Pott's Paraplegia—67 cases. Clin Orthop Relat Res 1996; (323) 122-128
  • 46 Vidyasagar C, Murthy HK. Spinal tuberculosis with neurological deficits. Natl Med J India 1996; 9 (1) 25-27
  • 47 Lezin A, Olindo S, Oliere S , et al. Human T lymphotropic virus type I (HTLV-I) proviral load in cerebrospinal fluid: a new criterion for the diagnosis of HTLV-I-associated myelopathy/tropical spastic paraparesis?. J Infect Dis 2005; 191 (11) 1830-1834
  • 48 Kira J, Fujihara K, Itoyama Y, Goto I, Hasuo K. Leukoencephalopathy in HTLV-I-associated myelopathy/tropical spastic paraparesis: MRI analysis and a two year follow-up study after corticosteroid therapy. J Neurol Sci 1991; 106 (1) 41-49
  • 49 Morgan DJ, Caskey MF, Abbehusen C , et al. Brain magnetic resonance imaging white matter lesions are frequent in HTLV-I carriers and do not discriminate from HAM/TSP. AIDS Res Hum Retroviruses 2007; 23 (12) 1499-1504
  • 50 Taylor GP, Goon P, Furukawa Y , et al. Zidovudine plus lamivudine in Human T-Lymphotropic Virus type-I-associated myelopathy: a randomised trial. Retrovirology 2006; 3: 63
  • 51 Nakagawa M, Nakahara K, Maruyama Y , et al. Therapeutic trials in 200 patients with HTLV-I-associated myelopathy/ tropical spastic paraparesis. J Neurovirol 1996; 2 (5) 345-355
  • 52 Izumo S, Goto I, Itoyama Y , et al. Interferon-alpha is effective in HTLV-I-associated myelopathy: a multicenter, randomized, double-blind, controlled trial. Neurology 1996; 46 (4) 1016-1021
  • 53 Oh U, Yamano Y, Mora CA , et al. Interferon-beta1a therapy in human T-lymphotropic virus type I-associated neurologic disease. Ann Neurol 2005; 57 (4) 526-534
  • 54 Mahieux R, Gessain A. The human HTLV-3 and HTLV-4 retroviruses: new members of the HTLV family. Pathol Biol (Paris) 2009; 57 (2) 161-166
  • 55 Chong J, Di Rocco A, Tagliati M, Danisi F, Simpson DM, Atlas SW. MR findings in AIDS-associated myelopathy. AJNR Am J Neuroradiol 1999; 20 (8) 1412-1416
  • 56 Hénin D, Smith TW, De Girolami U, Sughayer M, Hauw JJ. Neuropathology of the spinal cord in the acquired immunodeficiency syndrome. Hum Pathol 1992; 23 (10) 1106-1114
  • 57 Tan SV, Guiloff RJ, Henderson DC, Gazzard BG, Miller R. AIDS-associated vacuolar myelopathy and tumor necrosis factor-alpha (TNF alpha). J Neurol Sci 1996; 138 (1–2) 134-144
  • 58 Centers for Disease Control and Prevention (CDC). . Sexually Transmitted Diseases Treatment Guidelines, MMWR Morb Mortal Wkly Rep; 2010;59(RR–12):32–33.